Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

（BN）n及SiB（n-1）Nn（n=2-11）稳定结构的研究

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Banach空间中的幂级数方程

本文考虑Banach空间中形如x=u+sum from k=1 to ∞(a_kx~k)的幂级数方程,建立了一个比较定理,并将其应用于一定的非线性积分方程.     

一类广义非扩张映像的不动点定理

在 Ｂａｎａｃｈ空间中讨论一类广义非扩张映像的不动点的存在性和迭代逼近，以及不动点集的性质。     

OFDM系统中的峰值平均包络功率比上下界的分析

本文主要对OFDM系统中的峰值平均包络功率比(PMEPR)的上下界进行了推导.推导结果表明,PMEPR的上界仅和数据序列的非周期自相关函数有关,这对于迅速去除PMEPR超过给定门限的数据序列是非常有用的.从推导的PMEPR下界看,只有当子载波数N很少时,它才会随N变化较大.针对一个16子载波的BPSK OFDM系统,本文借助于PMEPR的上界还对一种降低PMEPR的选择性映射技术进行了分析,并给出了所有可能信息序列的PMEPR分布.分析结果表明,最大PMEPR约为6.5dB,比最坏情况下的PMEPR减少了5.5dB.     

一些Fuzzy映象的重合度

本文讨论一些Fuzzy映象的重合度的存在性,得出了一些新的重合度定理.本文所得结果统一和发展了引文[5～9]中的许多重要结果.     

MAPGIS在地质图件绘制中的应用

介绍了用地理信息系统进行地质信息管理的特点和优越性以及国产地理信息系统基础软件 -MAPGIS的数据结构、主要功能等。论述了在MAPGIS环境下绘制地质图件的基本方法和步骤。该系统实际应用于陕西省铜川矿务局煤矿地质信息的管理和图件绘制 ,实践证明该方法切实可行 ,效果明显。     

序补问题解的存在性

利用耦合不动点的方法得到了混合单调型算子的序补问题解的存在性．同时利用序补问题与隐变分不等式的关系给出了隐变分不等式解的存在性的新条件．     

向量变分不等式解的存在性

利用广义向量平衡问题解的存在性结论，给出了向量变分不等式解的存在性定理。