Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

Growth hormone signal transduction

Growth hormone (GH) promotes animal growth by stimulating bone and cartilage cell proliferation, and influences carbohydrate and lipid metabolism. Some of these effects are brought about indirectly via somatomedin induction in hepatocytes, others by acting directly on the target cells. In either case, GH first binds to specific receptors on cells to trigger a sequence of biochemical events culminating in a biological response. Recently much has been learnt about the molecular structure of GH receptor, its binding to ligand, and the ensuing signal transduction events.     

对异步机数学模型中一些问题的研究

本文推导异步机在d、q、O系统中的磁链方程时,将气隙磁场与漏磁场分开考虑,并根据各自特点采取了不同的处理方法,从而简化了推导过程,考虑到异步机与同步机及一般化电机在结构上的差异,在研究异步机的功率平衡时,利用等效电路的概念,进一步阐明了瞬变过程中异步机的功率平衡关系。     

3-Dimensional Body Measurement Technology

3 - dimensional body measurement technology, the basis of developing high technology in industry, accelerates digital development of aplparel industry. This paper briefly introduces the history of 3 - dimensional body measurement technology, and recounts the principle and primary structure of some types of 3 - dimensional automatic body measurement system. With this understanding, it discusses prospect of 3 - dimensional CAD and virtual technology used in apparel industry.     

非晶硒化镉超快光电探测器瞬态响应

报道淀积条件对以非晶态硒化镉（ａ－ＣｄＳｅ）为光敏介质的超快光电探测器瞬态响应特性的影响．     

多环节冲击测量系统方波响应时间的计算

实际的冲击高电压测量系统，通常由多个不同特性的环节组成．作者以最简洁的数学推导式，表达了多环节测量系统方波响应时间的计算方法。借助于这一计算方法．讨论了方波源波形非理想时，它对实际方波响应时间测量值的影响。所提出的反映原始方波质量的技术指标，可比“上升时间”更易确定，而且实用性强．     

AVAILABILITY ANALYSIS OF THE QUEUEING SYSTEM GI/PH/I WITH SERVER BREAKDOWNS

In the existing literature of Repairable Queueing Systems (RQS), i.e., queueing systems with server breakdowns, it is almost all assumed that interarrival times of successive customers are independent, identically exponentially distributed. In this paper, we deal with more generic system GI/PH/1 with server's exponential uptime and phase-type repair time. With matrix analysis theory, we establish the equilibrium condition and the characteristics of the system, derive the transient and stationary availability behavior of the system.     

钢液定氧测头响应时间和热平衡态

本文分别研究了ＺｒＯ２（ＭｇＯ）固体电解质管头壁厚，参比电极量对定氧测头响应时间的影响，得出了以ＺｒＯ２管头壁厚为０．６０－０．８０ｍｍ，Ｃｒ／Ｃｒ２Ｏ３参比电极加入量为４０－６０ｍｇ所组成的定氧测头响应速度最快，同时采用了“双偶法”对定氧测头在工作过程中的热平衡态进行了研究。结果表明：氧浓差电池中的传热是响应过程的控速步骤，氧电势曲线上峰值的产生是起源于电池中的热平衡态。     

三种群捕食-食饵离散系统的持久性

研究了具有第Ⅱ类功能性反应的三种群捕食-食饵离散系统，得到了保证该系统持久性的充分条件．