全文获取类型
收费全文 | 626篇 |
免费 | 8篇 |
国内免费 | 2篇 |
专业分类
系统科学 | 28篇 |
丛书文集 | 3篇 |
理论与方法论 | 9篇 |
现状及发展 | 275篇 |
研究方法 | 72篇 |
综合类 | 238篇 |
自然研究 | 11篇 |
出版年
2020年 | 5篇 |
2018年 | 7篇 |
2017年 | 11篇 |
2016年 | 15篇 |
2015年 | 12篇 |
2014年 | 13篇 |
2013年 | 12篇 |
2012年 | 44篇 |
2011年 | 45篇 |
2010年 | 17篇 |
2008年 | 31篇 |
2007年 | 22篇 |
2006年 | 24篇 |
2005年 | 25篇 |
2004年 | 31篇 |
2003年 | 19篇 |
2002年 | 18篇 |
2001年 | 13篇 |
2000年 | 10篇 |
1999年 | 13篇 |
1998年 | 6篇 |
1997年 | 4篇 |
1996年 | 4篇 |
1994年 | 4篇 |
1993年 | 8篇 |
1992年 | 9篇 |
1991年 | 7篇 |
1990年 | 6篇 |
1989年 | 14篇 |
1988年 | 8篇 |
1987年 | 5篇 |
1986年 | 11篇 |
1984年 | 6篇 |
1983年 | 5篇 |
1980年 | 10篇 |
1979年 | 8篇 |
1978年 | 11篇 |
1977年 | 9篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1974年 | 5篇 |
1973年 | 10篇 |
1972年 | 10篇 |
1971年 | 10篇 |
1970年 | 8篇 |
1969年 | 9篇 |
1968年 | 7篇 |
1967年 | 4篇 |
1966年 | 10篇 |
1965年 | 5篇 |
排序方式: 共有636条查询结果,搜索用时 31 毫秒
1.
Summary The disappearance of thrombin—formed in the blood, or added to serum-follows a manomolecular reaction-type. Heparin increases the reaction-velocity of this thrombin-inactivating process.Our investigation established that toluidine blue or kinase, which, according to the literature, bind heparin, strongly reduce the speed of thrombin-inactivation too. Therefore the heparin-binding capacity of these substances is also manifested in the decrease of thrombin-inactivation. 相似文献
2.
岳崇兴 《河南师范大学学报(自然科学版)》1995,(1)
本文用TC(Technicolor)模型,解释了L3L ̄+L ̄-γγ事例,具体分析发现四个L3事例可以由过程z→ρ°ρ°→L ̄+L ̄-P°(γγ)产生。 相似文献
3.
Ramsés Fuenmayor 《Systemic Practice and Action Research》1991,4(5):473-490
Both an ontoepistemology for reductionist modern science (counter-ontoepistemology) and an ontology for interpretive Systemology have been outlined in the two preceding papers in this special issue ofSystems Practice. In the present article, the notion of “truth” is interpreted in terms of both the ontoepistemology of “reductionism” and the ontology of interpretive systemology. Both interpretations are discussed. Such a discussion represents the objective of this paper, that is, to outline the epistemological “face” of the ontoepistemology of interpretive systemology. In order to design that “epistemological face,” the relation between ontology and epistemology must be clarified. Such a relation is seen from the standpoint already provided by the ontology. After the discussion on the notion of truth, the general shape of a systemic-interpretive inquiring process is outlined. 相似文献
4.
本文采用图论方法对饱和烷烃第二维里系数B与分子结构的关系进行了探讨,结果发现烷烃第二维里系数与Wiener指数具有较好的相关性,并建立了它们之间的一个定量关系。对C_2~C_8共39个饱和烷烃B的计算表明,计算值与文献值的一致性是令人满意的。本文不仅拓展了Wiener指数的应用领域,而且也有助于深入理解第二维里系数的物理意义。 相似文献
5.
D. Migliore-Samour M. Delaforge M. Jaouen D. Mansuy P. Jollès 《Cellular and molecular life sciences : CMLS》1989,45(9):882-886
Summary Immunomodulating lipopeptides lauroyl-L-Ala--D-Glu-LL-A2pmNH2-Gly (RP 44.102) and lauroyl-L-Ala--D-Glu-LL-A2pmNH2 (RP 56.142) were found to protect mice against the hepatotoxicity of paracetamol, which is due to cytochrome P-450 dependent formation of toxic metabolites and radicals. In fact they decreased the amount of hepatic microsomal cytochrome P-450, and the level of CCl4-induced lipid peroxidation. In contrast lauroyl-L-Ala--D-Glu-DD-A2pmNH2 (RP 53.204), which only differs by the configuration of the two chiral carbons of A2pm (diaminopimelic acid) and is not an immunomodulating agent, failed to protect against poisoning by paracetamol and had no effect on the level of hepatic cytochrome P-450 or the microsomal CCl4-induced lipid peroxidation. This provides a clear connection between the immunostimulating properties of a compound and its effects on xenobiotic biotransformations. 相似文献
6.
7.
Judith Polonsky Zoïa Varon Ch. Marazano Bernadette Arnoux G. R. Pettit J. M. Schmid M. Ochi H. Kotsuki 《Cellular and molecular life sciences : CMLS》1979,35(8):987-989
Summary 2 new limonoid-type terpenes have been isolated from an aqueous extract of seeds produced by the Eastern Himalayan (India) plantAphanamixis grandifolia Bl. By interpreting principally mass spectral and nuclear magnetic resonance data, the structures of 12-hydroxyamoorastatin (2b) and amoorastatone (3) were elucidated. Unequivocal evidence for the 12-hydroxyamoorastatin structural assignment was obtained by chemical conversion to sendanin (4). Amoorastatin derivative2b was found to significantly inhibit growth of the murine P388 lymphocytic leukemia cell lines but amoorastatone in the same system was inactive. In a comparative biological study, sendanin (4) and anthothecol (7) were also found significantly to inhibit growth of the P388 cell line, while rohitukin (8) and limonin (9) were found to be inactive.Part 63 of the series Antineoplastic Agents. For the previous contribution refer to G.R. Pettit, T.S. Krupa and R.M. Reynolds, Int. J. Peptide Protein Res., in preparation. The present investigation was supported in part by Public Health Research Grant No. CA-16049-05 from the National Cancer Institute, the Fannie E. Rippel Foundation, Mrs Mary Dell Pritzlaff, the Spencer T. and Ann W. Olin Foundation, Mr John F. Schmidt, and the Phoenix Coca-Cola Bottling Company. 相似文献
8.
Jutta Steinberger Jennifer Chu Rayelle Itoua Maïga Katia Sleiman Jerry Pelletier 《Cellular and molecular life sciences : CMLS》2017,74(9):1681-1692
Biotherapeutics have revolutionized modern medicine by providing medicines that would not have been possible with small molecules. With respect to cancer therapies, this represents the current sector of the pharmaceutical industry having the largest therapeutic impact, as exemplified by the development of recombinant antibodies and cell-based therapies. In cancer, one of the most common regulatory alterations is the perturbation of translational control. Among these, changes in eukaryotic initiation factor 4F (eIF4F) are associated with tumor initiation, progression, and drug resistance in a number of settings. This, coupled with the fact that systemic suppression of eIF4F appears well tolerated, indicates that therapeutic agents targeting eIF4F hold much therapeutic potential. Here, we discuss opportunities offered by biologicals for this purpose. 相似文献
9.
10.
Journal of Systems Science and Complexity - The idea of envelope of a family of plane curves is an elementary notion in differential geometry. As such, its implementation in dynamic geometry... 相似文献