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Zusammenfassung Vergleichend-histologische Untersuchung der Darmbeingefässe bei Wildhühnern und der White-Rock-Rasse zeigen eine stärkere Entwicklung der Wildhuhngefässe. Es scheint, dass das gesamte Gefäß-system bei den Wildhühnern, in Anpassung an die erhöhte Herzfrequenz und den gesteigerten Blutdruck bei besondern Erregungszuständen, über Schutzmechanismen in der Gefässwand verfügt. 相似文献
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Thirty-nine previously unpublished reports of the endangered black-footed ferret from Wyoming are listed with dates, locations, number of animals, sources, and comments. 相似文献
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Robert W. Buckheit III Maria Salgado Karen O. Martins Joel N. Blankson 《Cellular and molecular life sciences : CMLS》2013,70(6):1009-1019
The mechanisms by which a small percentage of HIV-1 infected individuals known as elite suppressors or controllers are able to control viral replication are not fully understood. Early cases of viremic control were attributed to infection with defective virus, but subsequent work has demonstrated that infection with a defective virus is not the exclusive cause of control. Replication-competent virus has been isolated from patients who control viral replication, and studies have demonstrated that evolution occurs in plasma virus but not in virus isolates from the latent reservoir. Additionally, transmission pair studies have demonstrated that patients infected with similar viruses can have dramatically different outcomes of infection. An increased understanding of the viral factors associated with control is important to understand the interplay between viral replication and host control, and has implications for the design of an effective therapeutic vaccine that can lead to a functional cure of HIV-1 infection. 相似文献
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We studied the white-tailed antelope ground squirrel during spring and summer 2006 to determine young-of-the-year and adult sex ratios in the Indian Wells Valley, San Bernardino County, California. We calculated a young-of-the-year sex ratio of 1.45:1 (female to male), whereas the adult sex ratio was approximately 1:1. Our young-ofthe-year sex ratio was greater than the 1.1:1 (female to male) natal sex ratio previously reported. Differences between young-of-the-year and adult sex ratios may represent low female young-of-the-year survivorship in the Indian Wells Valley. 相似文献
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T. L. Akasaka Lynne Olds-Arroyo J. J. Miller III 《Cellular and molecular life sciences : CMLS》1979,35(5):673-674
Summary Human lymphocytes stimulated in vitro by PHA or PWM incorporate3H-CdR into DNA, but less well than3H-TdR. More3H-CdR is incorporated in populations enriched for T cells. No3H-CdR is used by cells stimulated by lipopolysaccharides under circumstances in which3H-TdR is incorporated. We conclude that human T cells and B cells differ in their ability to use3H-CdR. 相似文献
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Green PH Alaedini A Sander HW Brannagan TH Latov N Chin RL 《Cellular and molecular life sciences : CMLS》2005,62(7-8):791-799
The extra-intestinal manifestations of celiac disease (CD), including ataxia and peripheral neuropathy, are increasingly being recognized as the presenting symptoms of this autoimmune disease. Although there is a greater understanding of the pathogenesis of the intestinal lesions in CD the mechanisms behind the neurologic manifestations of CD have not been elucidated. In this article, the authors review the cellular and molecular mechanisms behind the histopathologic changes in the intestine, discuss the presentation and characteristics of neurologic manifestations of CD, review the data on the mechanisms behind these manifestations, and discuss the diagnosis and treatment of CD. Molecular mimicry and intermolecular help may play a role in the development of neurologic complications.Received 11 March 2004; received after revision 29 October 2004; accepted 12 November 2004 相似文献
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G. M. Chisolm III J. L. Gainer A. J. Raineri Jr. 《Cellular and molecular life sciences : CMLS》1973,29(2):167-168
Résumé Les examens macroscopiques et microscopiques effectués sur l'aorte des lapins ont été mis en corrélation avec le degré de concentration de la protéine plasmique. Les résultats indiquent qu'une augmentation des protéines plasmiques correspond a un degré plus élevé d'athérosclérose. 相似文献
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G. D. Ledney E. D. Exum W. E. Jackson III 《Cellular and molecular life sciences : CMLS》1985,41(5):614-616
Summary Wounding mice shortly before or shortly after lethal60Co irradiation enhances survival. Survival of wounded-irradiated mice may be due to enhanced hematopoietic recovery as measured by endogenous spleen colony (E-CFU-s) formation.Supported by the Armed Forces Radiobiology Research Institute, Defense Nuclear Agency, under research Work Unit 00129. Views presented in this paper are those of the authors; no endorsement by the Defense Nuclear Agency has been given or should be inferred.Research was conducted according to the principles enunciated in the Guide for the Care and Use of Laboratory Animals' prepared by the Institute of Laboratory Research, National Research Council. 相似文献
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David M. Wilson III Anton Simeonov 《Cellular and molecular life sciences : CMLS》2010,67(21):3621-3631
APE1 is a multifunctional protein that possesses several nuclease activities, including the ability to incise at apurinic/apyrimidinic
(AP) sites in DNA or RNA, to excise 3′-blocking termini from DNA ends, and to cleave at certain oxidized base lesions in DNA.
Pre-clinical and clinical data indicate a role for APE1 in the pathogenesis of cancer and in resistance to DNA-interactive
drugs, particularly monofunctional alkylators and antimetabolites. In an effort to improve the efficacy of therapeutic compounds,
such as temozolomide, groups have begun to develop high-throughput screening assays and to identify small molecule inhibitors
against APE1 repair nuclease activities. It is envisioned that such inhibitors will be used in combinatorial treatment paradigms
to enhance the efficacy of DNA-interactive drugs that introduce relevant cytotoxic DNA lesions. In this review, we summarize
the current state of the efforts to design potent and selective inhibitors against APE1 AP site incision activity. 相似文献