Magnetism parameters characteristics of drilling deposits in Jianghan Plain and indication for forming of the Yangtze River Three Gorges

The forming time of the Yangtze River Three Gorges is considered as one of keys in the research on the Yangtze River, also is one of the most disputed hotspots. In order to solve the difficult problem, the authors adopt the internationally recognized thoughts and methods of substance tracing from source to sink. The lithologic characteristics, magnetic parameters and magnetic mineral characteristics of deposits in 2 bores are analyzed, which are both sampled from the sedimentary center of the Jianghan Plain. The results are as follows： At about 110 m depth of the core, the contents of coarse materials and stable magnetic mineral both increase significantly. Meanwhile, the magnetic susceptibility of sediment, saturation isothermal remanent magnetization and magnetic susceptibility values of anhysteretic remanent magnetism increase suddenly, which all reflect that at about 110 m depth, the important adjustment has appeared in water system of the Jianghan Plain, and the sedimentary environment and material composition have changed greatly. And it may be the horizon where the Yangtze River Three Gorges formed, its forming time reflected by the paleomagnetic dating is between 1.17 and 1.12Ma B.P.     

BaMg（1-x）/3）ZrxNb2（1-x）/3）]O3微波介质陶瓷的红外光谱

利用传统固相陶瓷烧结工艺在1520℃下制备Ba[Mg（1-x）/3ZrxNb2（1-x）/3]O3（BMZN,x=0,0.10,0.15）微波介质陶瓷.通过远红外光谱（FIR）来分析研究B位Zr4＋取代对BMN陶瓷晶体结构和介电性能的影响.研究发现,随着Zr4＋取代的增加,红外光谱上在370 cm-1附近的振动模发生分裂而出现新的极化模式;410 cm-1附近的振动模消失;230,290和510 cm-1附近的振动模的频率向高波数偏移且强度明显降低.这些红外振动模的变化表明随着Ba Zr O3的增加,陶瓷的晶体结构发生转变,由六方晶系逐步转变为立方晶系.分析了陶瓷介电性能与红外模式的内在联系.     

QSAR analysis of substituted benzylamino- and heterocyclylmethylamino-carbodithioate derivatives of 4-（3H）-quinazolinone using CoMFA and SCORE2.0

Thymidylate synthase (TS) is a critical enzyme for DNA biosynthesis and many nonclassical lipophilic antifolates targeting this enzyme are quite efficient and encouraging as antitumor drugs. In this paper, the binding model of 14 antifolates of substituted benzylamino- and heterocyclylmethylamino- carbodithioate derivatives of 4-(3H)-quinazolinone with TS is examined using molecular simulation methods―― FlexiDock and SCORE2.0. The resulting conformation and orientation of these antifolates are directly applied to CoMFA study. The robust QSAR model, its three-dimensional contour map, and binding score of these antifolates derived from SCORE2.0 provide guidelines for structural optimiza- tion of current antifolates. The experiment indicates that deletion of cancer chemopreventive structure of dithiocarbamate is unfavorable for interaction between TS and antifolates.