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1.
Visual abilities change over the visual field. For example, our ability to detect movement is better in peripheral vision than in foveal vision, but colour discrimination is markedly worse. The deterioration of colour vision has been attributed to reduced colour specificity in cells of the midget, parvocellular (PC) visual pathway in the peripheral retina. We have measured the colour specificity (red-green chromatic modulation sensitivity) of PC cells at eccentricities between 20 and 50 degrees in the macaque retina. Here we show that most peripheral PC cells have red-green modulation sensitivity close to that of foveal PC cells. This result is incompatible with the view that PC pathway cells in peripheral retina make indiscriminate connections ('random wiring') with retinal circuits devoted to different spectral types of cone photoreceptors. We show that selective cone connections can be maintained by dendritic field anisotropy, consistent with the morphology of PC cell dendritic fields in peripheral retina. Our results also imply that postretinal mechanisms contribute to the psychophysically demonstrated deterioration of colour discrimination in the peripheral visual field. 相似文献
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van Rossum DB Patterson RL Sharma S Barrow RK Kornberg M Gill DL Snyder SH 《Nature》2005,434(7029):99-104
Many ion channels are regulated by lipids, but prominent motifs for lipid binding have not been identified in most ion channels. Recently, we reported that phospholipase Cgamma1 (PLC-gamma1) binds to and regulates TRPC3 channels, components of agonist-induced Ca2+ entry into cells. This interaction requires a domain in PLC-gamma1 that includes a partial pleckstrin homology (PH) domain-a consensus lipid-binding and protein-binding sequence. We have developed a gestalt algorithm to detect hitherto 'invisible' PH and PH-like domains, and now report that the partial PH domain of PLC-gamma1 interacts with a complementary partial PH-like domain in TRPC3 to elicit lipid binding and cell-surface expression of TRPC3. Our findings imply a far greater abundance of PH domains than previously appreciated, and suggest that intermolecular PH-like domains represent a widespread signalling mode. 相似文献
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Early experience and immunity 总被引:5,自引:0,他引:5
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Temperature dependence of cation permeability of dog red cells 总被引:1,自引:0,他引:1
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P N Goodfellow E A Jones V Van Heyningen E Solomon M Bobrow V Miggiano W F Bodmer 《Nature》1975,254(5497):267-269
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Zusammenfassung Bei Hunden, die wegen Infusion von NaHCO3, Na-Laktat oder NaOH alkalischen Harn produzierten, wurden «stop-flow»-Versuche durchgeführt. Es konnte gezeigt werden, dass unter diesen Umständen distal eine Ansäuerung des Tubulusharns stattfindet, so dass die Alkalisierung in den proximalen Abschnitten stattfinden muss. 相似文献