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Correction to: The role of connexin proteins and their channels in radiation-induced atherosclerosis
Ramadan Raghda Baatout Sarah Aerts An Leybaert Luc 《Cellular and molecular life sciences : CMLS》2021,78(10):4847-4847
Cellular and Molecular Life Sciences - A correction to this paper has been published: https://doi.org/10.1007/s00018-021-03811-z 相似文献
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A blend of small molecules regulates both mating and development in Caenorhabditis elegans 总被引:1,自引:0,他引:1
Srinivasan J Kaplan F Ajredini R Zachariah C Alborn HT Teal PE Malik RU Edison AS Sternberg PW Schroeder FC 《Nature》2008,454(7208):1115-1118
In many organisms, population-density sensing and sexual attraction rely on small-molecule-based signalling systems. In the nematode Caenorhabditis elegans, population density is monitored through specific glycosides of the dideoxysugar ascarylose (the 'ascarosides') that promote entry into an alternative larval stage, the non-feeding and highly persistent dauer stage. In addition, adult C. elegans males are attracted to hermaphrodites by a previously unidentified small-molecule signal. Here we show, by means of combinatorial activity-guided fractionation of the C. elegans metabolome, that the mating signal consists of a synergistic blend of three dauer-inducing ascarosides, which we call ascr#2, ascr#3 and ascr#4. This blend of ascarosides acts as a potent male attractant at very low concentrations, whereas at the higher concentrations required for dauer formation the compounds no longer attract males and instead deter hermaphrodites. The ascarosides ascr#2 and ascr#3 carry different, but overlapping, information, as ascr#3 is more potent as a male attractant than ascr#2, whereas ascr#2 is slightly more potent than ascr#3 in promoting dauer formation. We demonstrate that ascr#2, ascr#3 and ascr#4 are strongly synergistic, and that two types of neuron, the amphid single-ciliated sensory neuron type K (ASK) and the male-specific cephalic companion neuron (CEM), are required for male attraction by ascr#3. On the basis of these results, male attraction and dauer formation in C. elegans appear as alternative behavioural responses to a common set of signalling molecules. The ascaroside signalling system thus connects reproductive and developmental pathways and represents a unique example of structure- and concentration-dependent differential activity of signalling molecules. 相似文献
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Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast. 总被引:11,自引:0,他引:11
F Foor S A Parent N Morin A M Dahl N Ramadan G Chrebet K A Bostian J B Nielsen 《Nature》1992,360(6405):682-684
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Urban growth represents specific response to economic, demographic and environmental conditions. Rapid urbanization and industrializations have resulted in sharp land cover changes. The present investigation was carried out from Shaoxing City to quantify satellite-derived estimates of urban growth using a three-epoch time series Landsat TM data for the years 1984, 1997 and ETM 2000. The methodology used was based on post classification comparison. The use of GIS allowed spatial analysis of the data derived from remotely sensed images. Results showed that the built-up area surrounding Shaoxing City has expanded at an annual average of 7 km2. Analysis of the classified map showed that the physical growth of urban area is upsetting the other land cover classes such as farming, water resources, etc. The study conclusion mainly emphasized the need for sustainable urban capacity. 相似文献
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Danilczyk U Sarao R Remy C Benabbas C Stange G Richter A Arya S Pospisilik JA Singer D Camargo SM Makrides V Ramadan T Verrey F Wagner CA Penninger JM 《Nature》2006,444(7122):1088-1091
Angiotensin -converting enzyme 2 (ACE2) is a regulator of the renin angiotensin system involved in acute lung failure, cardiovascular functions and severe acute respiratory syndrome (SARS) infections in mammals. A gene encoding a homologue to ACE2, termed collectrin (Tmem27), has been identified in immediate proximity to the ace2 locus. The in vivo function of collectrin was unclear. Here we report that targeted disruption of collectrin in mice results in a severe defect in renal amino acid uptake owing to downregulation of apical amino acid transporters in the kidney. Collectrin associates with multiple apical transporters and defines a novel group of renal amino acid transporters. Expression of collectrin in Xenopus oocytes and Madin-Darby canine kidney (MDCK) cells enhances amino acid transport by the transporter B(0)AT1. These data identify collectrin as a key regulator of renal amino acid uptake. 相似文献
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During division of metazoan cells, the nucleus disassembles to allow chromosome segregation, and then reforms in each daughter cell. Reformation of the nucleus involves chromatin decondensation and assembly of the double-membrane nuclear envelope around the chromatin; however, regulation of the process is still poorly understood. In vitro, nucleus formation requires p97 (ref. 3), a hexameric ATPase implicated in membrane fusion and ubiquitin-dependent processes. However, the role and relevance of p97 in nucleus formation have remained controversial. Here we show that p97 stimulates nucleus reformation by inactivating the chromatin-associated kinase Aurora B. During mitosis, Aurora B inhibits nucleus reformation by preventing chromosome decondensation and formation of the nuclear envelope membrane. During exit from mitosis, p97 binds to Aurora B after its ubiquitylation and extracts it from chromatin. This leads to inactivation of Aurora B on chromatin, thus allowing chromatin decondensation and nuclear envelope formation. These data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation. 相似文献
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