排序方式: 共有54条查询结果,搜索用时 15 毫秒
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Neuroplasticity: changes in grey matter induced by training 总被引:3,自引:0,他引:3
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Döring A Gieger C Mehta D Gohlke H Prokisch H Coassin S Fischer G Henke K Klopp N Kronenberg F Paulweber B Pfeufer A Rosskopf D Völzke H Illig T Meitinger T Wichmann HE Meisinger C 《Nature genetics》2008,40(4):430-436
Serum uric acid concentrations are correlated with gout and clinical entities such as cardiovascular disease and diabetes. In the genome-wide association study KORA (Kooperative Gesundheitsforschung in der Region Augsburg) F3 500K (n = 1,644), the most significant SNPs associated with uric acid concentrations mapped within introns 4 and 6 of SLC2A9, a gene encoding a putative hexose transporter (effects: -0.23 to -0.36 mg/dl per copy of the minor allele). We replicated these findings in three independent samples from Germany (KORA S4 and SHIP (Study of Health in Pomerania)) and Austria (SAPHIR; Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk), with P values ranging from 1.2 x 10(-8) to 1.0 x 10(-32). Analysis of whole blood RNA expression profiles from a KORA F3 500K subgroup (n = 117) showed a significant association between the SLC2A9 isoform 2 and urate concentrations. The SLC2A9 genotypes also showed significant association with self-reported gout. The proportion of the variance of serum uric acid concentrations explained by genotypes was about 1.2% in men and 6% in women, and the percentage accounted for by expression levels was 3.5% in men and 15% in women. 相似文献
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Arne Tiselius 《Cellular and molecular life sciences : CMLS》1961,17(10):433-443
Summary A survey is given of some recent progress, particularly in the author's own laboratory, of methods for the separation of macromolecules and particles of biological origin, as viruses, bacteriophage, microsomes, cell fragments, bacteria and whole cells. Special attention is given to recent developments in zone electrophoresis, protein chromatography, gel filtration and the new partition methods for separation of particles and macromolecules (Albertsson). A number of examples are given to illustrate the various applications. Special emphasis is laid upon the new possibilities for biochemical-genetic studies by application of high-resolution separation methods, and the significance of particle separation methods as applied to fragments of biological structures in providing a tool for structure investigations on a macromolecular level—a field which also should be of considerable interest from a chemical point of view.
DrittePaul-Karrer-Vorlesung gehalten an der Universität Zürich am 5. Juli 1961. 相似文献
DrittePaul-Karrer-Vorlesung gehalten an der Universität Zürich am 5. Juli 1961. 相似文献
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Arne Ölander 《Cellular and molecular life sciences : CMLS》1948,4(11):425-425
Zusammenfassung Es wird vorgeschlagen, die Freie-Energie-Funktionen vonHelmholtz undGilbert Lewis alsEnponie undEnchresie zu bezeichnen. 相似文献
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Justyna Sosna Susann Voigt Sabine Mathieu Arne Lange Lutz Thon Parvin Davarnia Thomas Herdegen Andreas Linkermann Andrea Rittger Francis Ka-Ming Chan Dieter Kabelitz Stefan Schütze Dieter Adam 《Cellular and molecular life sciences : CMLS》2014,71(2):331-348
Programmed necrosis is important in many (patho)physiological settings. For specific therapeutic intervention, however, a better knowledge is required whether necrosis occurs through one single “core program” or through several independent pathways. Previously, the poly(ADP-ribose) polymerase (PARP) pathway has been suggested as a crucial element of tumor necrosis factor (TNF)-mediated necroptosis. Here, we show that TNF-induced necroptosis and the PARP pathway represent distinct and independent routes to programmed necrosis. First, DNA-alkylating agents such as 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) or methyl methanesulfonate rapidly activate the PARP pathway, whereas this is a late and secondary event in TNF-induced necroptosis. Second, inhibition of the PARP pathway does not protect against TNF-induced necroptosis, e.g., the PARP-1 inhibitor 3-AB prevented MNNG- but not TNF-induced adenosine-5′-triposphate depletion, translocation of apoptosis-inducing factor, and necrosis. Likewise, olaparib, a more potent and selective PARP-1 inhibitor failed to block TNF-induced necroptosis, identical to knockdown/knockout of PARP-1, pharmacologic and genetic interference with c-Jun N-terminal kinases and calpain/cathepsin proteases as further components of the PARP pathway. Third, interruption of TNF-induced necroptosis by interference with ceramide generation, RIP1 or RIP3 function or by the radical scavenger butylated hydroxyanisole did not prevent programmed necrosis through the PARP pathway. In summary, our results suggest that the currently established role of the PARP pathway in TNF-induced necroptosis needs to be revised, with consequences for the design of future therapeutic strategies. 相似文献
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