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Role of bombesin-related peptides in the mediation or integration of the stress response 总被引:3,自引:0,他引:3
In addition to the relatively well established role of corticotropin-releasing hormone (CRH) and arginine-vasopressin (AVP)
in the mediation of the stress response, there is reason to believe that bombesin-like peptides (BN-LPs) may also contribute
to the mediation or integration of these responses and thus might be considered as putative 'stress peptides'. This review
provides evidence supporting this contention by showing that (i) BN-LPs are present at brain sites known to be activated by
stressors, (ii) stressor exposure alters utilization of BN-related peptides, (iii) exogenous BN administration mimics the
endocrine, autonomic and/or behavioral effects elicited by stressors, and (iv) antagonism of BN action attenuates the behavioral
and/or neurochemical effects of stressors or of exogenously administered peptide. The evidence presented also suggests that
BN-LPs mediate their stress-relevant effects through activation of CRH and/or AVP neurons. Several hypothetical mechanisms
for such peptidergic interactions are discussed as to the implications of considering BN-LPs as 'stress peptides'.
Received 16 July 2001; received after revision 27 August 2001; accepted 28 August 2001 相似文献
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This paper reviews some of the existing models for major process improvement and puts forward an overall framework for such a project. It considers the main reasons why operational change initiatives fail. A case study of process improvement in the financial services sector is used to illustrate the conclusions drawn. The critical role of vision in successful operational change is discussed. 相似文献
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