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Functions and pathologies of BiP and its interaction partners 总被引:1,自引:1,他引:0
J. Dudek J. Benedix S. Cappel M. Greiner C. Jalal L. Müller R. Zimmermann 《Cellular and molecular life sciences : CMLS》2009,66(9):1556-1569
The endoplasmic reticulum (ER) is involved in a variety of essential and interconnected processes in human cells, including
protein biogenesis, signal transduction, and calcium homeostasis. The central player in all these processes is the ER-lumenal
polypeptide chain binding protein BiP that acts as a molecular chaperone. BiP belongs to the heat shock protein 70 (Hsp70)
family and crucially depends on a number of interaction partners, including co-chaperones, nucleotide exchange factors, and
signaling molecules. In the course of the last five years, several diseases have been linked to BiP and its interaction partners,
such as a group of infectious diseases that are caused by Shigella toxin producing E. coli. Furthermore, the inherited diseases Marinesco-Sj?gren syndrome, autosomal dominant polycystic liver disease, Wolcott-Rallison
syndrome, and several cancer types can be considered BiP-related diseases. This review summarizes the physiological and pathophysiological
characteristics of BiP and its interaction partners.
Received 20 November 2008; received after revision 09 December 2008; accepted 12 December 2008 相似文献
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The effects of the welding current mode in resistance spot welding on the microstructure and mechanical properties of advanced high-strength steel dual-phase 590 (DP590) sheets were investigated. Results showed that a rough martensitic structure was formed in the weld zone of the sample welded via the single-pulsed mode, whereas the microstructure in the heat-affected zone consisted of a very rough martensitic microstructure and rough ferrite. However, using the secondary pulse mode led to the formation of tempered martensite in the weld zone. The maximum load and the energy absorption to failure of the samples with the secondary pulsed cycle were higher than those of the samples with the single-pulsed mode. Tensile shear results indicated that the secondary pulsed mode could significantly change the mode of failure upon shear tension testing. Therefore, the obtained results suggest that the use of secondary pulsed mode can improve the microstructural feature and mechanical properties of advanced high-strength steel DP590 welds. 相似文献
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The aim of this paper is to present a rigorous mathematical proof of the dynamical laws for the topological solitons( magnetic vortices) in ferromagnets and anti-ferromagnets. It is achieved through the conservation laws for the topological vorticity and the weak convergence methods. 相似文献
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