排序方式: 共有41条查询结果,搜索用时 171 毫秒
1.
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer 总被引:1,自引:0,他引:1
2.
Kondo Y Shen L Cheng AS Ahmed S Boumber Y Charo C Yamochi T Urano T Furukawa K Kwabi-Addo B Gold DL Sekido Y Huang TH Issa JP 《Nature genetics》2008,40(6):741-750
Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications, polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation. The relationship between DNA hypermethylation and these histone modifications is not completely understood. Using chromatin immunoprecipitation microarrays (ChIP-chip) in prostate cancer cells compared to normal prostate, we found that up to 5% of promoters (16% CpG islands and 84% non-CpG islands) were enriched with H3K27triM. These genes were silenced specifically in prostate cancer, and those CpG islands affected showed low levels of DNA methylation. Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation. These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation. 相似文献
3.
T. Yoshikawa Y. Furukawa Y. Wakamatsu M. Kondo 《Cellular and molecular life sciences : CMLS》1982,38(4):501-502
Summary Immunopotentiators such as BCG, levamisole, PS-K and OK-432 prevent carbon tetrachloride (CCl4) hepatotoxicity, and in spite of exposure to CCl4 the liver tissue levels of thiobarbituric acid (TBA) reactive substances were not increased in rats pretreated with such immunopotentiators. 相似文献
4.
Photocatalyst releasing hydrogen from water 总被引:4,自引:0,他引:4
Direct splitting of water using a particulate photocatalyst would be a good way to produce clean and recyclable hydrogen on a large scale, and in the past 30 years various photocatalysts have been found that function under visible light. Here we describe an advance in the catalysis of the overall splitting of water under visible light: the new catalyst is a solid solution of gallium and zinc nitrogen oxide, (Ga(1-x)Zn(x))(N(1-x)O(x)), modified with nanoparticles of a mixed oxide of rhodium and chromium. The mixture functions as a promising and efficient photocatalyst in promoting the evolution of hydrogen gas. 相似文献
5.
Retinopathy and attenuated circadian entrainment in Crx-deficient mice 总被引:22,自引:0,他引:22
Crx, an Otx-like homeobox gene, is expressed specifically in the photoreceptors of the retina and the pinealocytes of the pineal gland. Crx has been proposed to have a role in the regulation of photoreceptor-specific genes in the eye and of pineal-specific genes in the pineal gland. Mutations in human CRX are associated with the retinal diseases, cone-rod dystrophy-2 (adCRD2; refs 3, 4, 5), retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA), which all lead to loss of vision. We generated mice carrying a targeted disruption of Crx. Crx-/- mice do not elaborate photoreceptor outer segments and lacked rod and cone activity as assayed by electroretinogram (ERG). Expression of several photoreceptor- and pineal-specific genes was reduced in Crx mutants. Circadian entrainment was also affected in Crx-/- mice. 相似文献
6.
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis 总被引:28,自引:0,他引:28
7.
8.
9.
Haemagglutinin of rubella virus 总被引:2,自引:0,他引:2
10.