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Péterfy M Ben-Zeev O Mao HZ Weissglas-Volkov D Aouizerat BE Pullinger CR Frost PH Kane JP Malloy MJ Reue K Pajukanta P Doolittle MH 《Nature genetics》2007,39(12):1483-1487
Hypertriglyceridemia is a hallmark of many disorders, including metabolic syndrome, diabetes, atherosclerosis and obesity. A well-known cause is the deficiency of lipoprotein lipase (LPL), a key enzyme in plasma triglyceride hydrolysis. Mice carrying the combined lipase deficiency (cld) mutation show severe hypertriglyceridemia owing to a decrease in the activity of LPL and a related enzyme, hepatic lipase (HL), caused by impaired maturation of nascent LPL and hepatic lipase polypeptides in the endoplasmic reticulum (ER). Here we identify the gene containing the cld mutation as Tmem112 and rename it Lmf1 (Lipase maturation factor 1). Lmf1 encodes a transmembrane protein with an evolutionarily conserved domain of unknown function that localizes to the ER. A human subject homozygous for a deleterious mutation in LMF1 also shows combined lipase deficiency with concomitant hypertriglyceridemia and associated disorders. Thus, through its profound effect on lipase activity, LMF1 emerges as an important candidate gene in hypertriglyceridemia. 相似文献
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Temporal activity patterns for Dipodomys ordii were generally bimodal during the summer, with the highest peak occurring during early predawn hours when conditions were optimum for water conservation. Removal of dominant members in the population resulted in a substantial shift in the activity pattern to increased activity during the evening hours. 相似文献
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E Rodriguez M Aregullin T Nishida S Uehara R Wrangham Z Abramowski A Finlayson G H Towers 《Experientia》1985,41(3):419-420
Two African species of Aspilia (Asteraceae), which are used medicinally by man and which are eaten by wild chimpanzees in an unusual manner, were found to contain the potent antibiotic thiarubrine A as a major leaf phytochemical. Its presence in leaf material strengthens the view that the feeding behavior of wild chimpanzees is related to special physiological or pharmacological effects on the animals. 相似文献
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J. S. Finlayson A. Forssberg G. Dreyfus 《Cellular and molecular life sciences : CMLS》1959,15(3):107-108
Zusammenfassung Untersuchungen über die Stabilität der Eiweißstoffe von Landschütz-Aszites-Tumoren wurden an C14-Glykokoll,-Valin oder -Leucin markierten Zellen durchgeführt. Es wurde festgestellt, dass während der Zellteilung und des Wachstums kontinuierlich etwa 5–10% pro Tag der einmal gebundenen C14-Aktivität als niedrigmolekulare Komponenten in die Aszitesflüssigkeit ausgeschieden wird. Diese Instabilität kommt offenbar durch intrazellulare Umsetzung der Eiweißstoffe und nicht durch Ausscheidung ganzer Eiweissmoleküle zustande. 相似文献
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This paper argues in favour of a closer link between the decision and the forecast evaluation problems. Although the idea of using decision theory for forecast evaluation appears early in the dynamic stochastic programming literature, and has continued to be used with meteorological forecasts, it is hardly mentioned in standard academic texts on economic forecasting. Some of the main issues involved are illustrated in the context of a two‐state, two‐action decision problem as well as in a more general setting. Relationships between statistical and economic methods of forecast evaluation are discussed and links between the Kuipers score used as a measure of forecast accuracy in the meteorology literature and the market timing tests used in finance are established. An empirical application to the problem of stock market predictability is also provided, and the conditions under which such predictability could be explained in the presence of transaction costs are discussed. Copyright © 2000 John Wiley & Sons, Ltd. 相似文献