Noradrenolutin

Zusammenfassung Herstellung und einige Eigenschaften von kristallinem Noradrenolutin (5,6-Dioxyindoxyl), dem gelbgrün fluoreszierenden Oxydationsprodukt von Noradrenalin, werden beschrieben.     

The hydroxyskatoles

Zusammenfassung Synthesen und Eigenschaften von 4-, 5-, 6- und 7-Hydroxyskatol werden beschrieben.     

Base excision repair and design of small molecule inhibitors of human DNA polymerase β

Base excision repair (BER) can protect a cell after endogenous or exogenous genotoxic stress, and a deficiency in BER can render a cell hypersensitive to stress-induced apoptotic and necrotic cell death, mutagenesis, and chromosomal rearrangements. However, understanding of the mammalian BER system is not yet complete as it is extraordinarily complex and has many back-up processes that complement a deficiency in any one step. Due of this lack of information, we are unable to make accurate predictions on therapeutic approaches targeting BER. A deeper understanding of BER will eventually allow us to conduct more meaningful clinical interventions. In this review, we will cover historical and recent information on mammalian BER and DNA polymerase β and discuss approaches toward development and use of small molecule inhibitors to manipulate BER. With apologies to others, we will emphasize results obtained in our laboratory and those of our collaborators.     

The isolation of dehydrodiisoeugenol from the aril ofMyristica fragrans Houtt

Résumé On a pu isoler le déshydrodiisoeugénol de l'arille deMyristica fragrans Houtt. (fleur de muscade).

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Acknowledgments. The authors wish to express their thanks to Dr.W. D. Jamieson and MrD. Embree of the Atlantic Regional Laboratory for the mass spectroscopic data and to Dr.E. von Rudloff and Mr.W. C. Haid of the Prairie Regional Laboratory (Saskatoon) for the 100 MHz NMR data.     

Adrenochrome-thiol addition products

Résumé Les aminochromes réagissent avec les thiols à des pH neutres ou légèrement acides en donnant des dihydro-4,9-aminochromes-9-thiosubstitués. On a pu isoler un dérivép-nitrophénylhydrazonique de ce genre de composé et déterminer sa structure à l'aide de la spectroscopie RMN.