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Based on the biological model of cell-to-cell communication proposed by A. Rustom et al. (Science, 2004, 303: 1007-1010), we investigate the possibilities to apply P systems with dynamic channels transporting membrane vesicles for describing processes in distributed systems. 相似文献
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Based on the biological model of cell-to-cell communication proposed by A. Rustom et al. (Science, 2004, 303: 1007—1010), we investigate the possibilities to apply P systems with dynamic channels transporting membrane vesicles for describing processes in distributed systems. 相似文献
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Mesenchymal stem cells and neural crest stem cells from adult bone marrow: characterization of their surprising similarities and differences 总被引:1,自引:1,他引:0
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Genome-wide atlas of gene expression in the adult mouse brain 总被引:1,自引:0,他引:1
Lein ES Hawrylycz MJ Ao N Ayres M Bensinger A Bernard A Boe AF Boguski MS Brockway KS Byrnes EJ Chen L Chen L Chen TM Chin MC Chong J Crook BE Czaplinska A Dang CN Datta S Dee NR Desaki AL Desta T Diep E Dolbeare TA Donelan MJ Dong HW Dougherty JG Duncan BJ Ebbert AJ Eichele G Estin LK Faber C Facer BA Fields R Fischer SR Fliss TP Frensley C Gates SN Glattfelder KJ Halverson KR Hart MR Hohmann JG Howell MP Jeung DP Johnson RA Karr PT Kawal R Kidney JM Knapik RH Kuan CL Lake JH Laramee AR 《Nature》2007,445(7124):168-176
Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the nervous system. We describe here an anatomically comprehensive digital atlas containing the expression patterns of approximately 20,000 genes in the adult mouse brain. Data were generated using automated high-throughput procedures for in situ hybridization and data acquisition, and are publicly accessible online. Newly developed image-based informatics tools allow global genome-scale structural analysis and cross-correlation, as well as identification of regionally enriched genes. Unbiased fine-resolution analysis has identified highly specific cellular markers as well as extensive evidence of cellular heterogeneity not evident in classical neuroanatomical atlases. This highly standardized atlas provides an open, primary data resource for a wide variety of further studies concerning brain organization and function. 相似文献
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