桩基动态检测分析

提出的桩基动态检测方法可以诊断混凝土灌注桩的桩身质量.判断桩基混凝土的强度和桩长,根据应力波在传播途中遇到阻抗面时会产生反射波与透射波的原理,诊断桩基缺陷的类型,并用相关分析法确定了单桩允许承载力.     

筒中筒结构刚性加强层作用机理分析

通过对某４８层筒中筒结构在３５层处设置刚性层效果的计算分析，提出筒中筒结构设置刚性层的作用机理在于提高翼缘框架的轴向抗侧作用，影响设置刚性层效果的主要因素在于外框筒裙梁刚度     

面向脑MR影像分割与偏置场修正的FCM方法

传统模糊C-均值(fuzzy C-means,FCM)算法以及结合空间信息的改进方法在分割脑磁共振(magnetic resonance,MR)影像时对噪声十分敏感,且无法消除脑MR影像中的偏置场。针对上述问题,提出一种面向脑MR影像分割与偏置场修正的FCM方法。该方法充分利用图像中的空间局部信息和非局部信息,分别构造出多局部信息模糊因子和非局部权重,在提高算法抗噪性的同时,尽可能多地保持图像细节;建立偏置场模型,以去除脑MR影像中的灰度不均匀性;将提出的多局部信息模糊因子和非局部权重嵌入到带有偏置场模型的FCM方法中,以实现噪声和偏置场条件下的脑MR影像分割。实验结果表明,与其他方法相比,所提方法对脑MR影像中的噪声具有更强的抑制能力,且能够有效消除偏置场对脑MR影像分割的影响,具有更优的分割性能。     

基于DSCM的竹材顺纹抗拉弹性模量测定

将数字散斑相关方法(DSCM)用于研究竹材顺纹抗拉弹性模量,并将结果与常规引伸计法结果进行了比较。结果表明两种测定方法误差不超过5%,说明DSCM方法能成功运用于竹材的顺纹抗拉弹性模量的测定。利用该方法测定了5个不同竹龄靠近竹青处、竹肉及靠近竹黄处竹材的顺纹抗拉弹性模量。结果表明:从竹青至竹黄竹材顺纹抗拉弹性模量大致呈依次减小的趋势;随着竹龄的增大,竹材顺纹抗拉弹性模量也呈逐渐增加的趋势。     

桥梁承载能力状态评估的模糊神经网络推理方法

在综合现有的状态评估理论方法的基础上,提出了基于层次分析的承载能力状态评估模型.结合模糊理论和神经网络技术,建立了一套基于监测信息输入的模糊神经网络推理系统框架,并利用模糊规则生成的规则库作为神经网络训练和学习的样本.利用实例验证了采用此智能评估技术进行承载能力状态评估的可行性和实用性.     

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Many components and pathways transducing multifaceted and deleterious effects of stress stimuli remain ill-defined. The Ran-binding protein 2 (RanBP2) interactome modulates the expression of a range of clinical and cell-context-dependent manifestations upon a variety of stressors. We examined the role of Ranbp2 haploinsufficiency on cellular and metabolic manifestations linked to tyrosine-hydroxylase (TH(+)) dopaminergic neurons and glial cells of the brain and retina upon acute challenge to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a parkinsonian neurotoxin, which models facets of Parkinson disease. MPTP led to stronger akinetic parkinsonism and slower recovery in Ranbp2 (+/-) than wild-type mice without viability changes of brain TH(+)-neurons of either genotype, with the exception of transient nuclear atypia via changes in chromatin condensation of Ranbp2 (+/-) TH(+)-neurons. Conversely, the number of wild-type retinal TH(+)-amacrine neurons compared to Ranbp2 (+/-) underwent milder declines without apoptosis followed by stronger recoveries without neurogenesis. These phenotypes were accompanied by a stronger rise of EdU(+)-proliferative cells and non-proliferative gliosis of GFAP(+)-Müller cells in wild-type than Ranbp2 (+/-) that outlasted the MPTP-insult. Finally, MPTP-treated wild-type and Ranbp2 (+/-) mice present distinct metabolic footprints in the brain or selective regions thereof, such as striatum, that are supportive of RanBP2-mediated regulation of interdependent metabolic pathways of lysine, cholesterol, free-fatty acids, or their β-oxidation. These studies demonstrate contrasting gene-environment phenodeviances and roles of Ranbp2 between dopaminergic and glial cells of the brain and retina upon oxidative stress-elicited signaling and factors triggering a continuum of metabolic and cellular manifestations and proxies linked to oxidative stress, and chorioretinal and neurological disorders such as Parkinson.     

基于均匀设计和最优化技术的树脂混凝土最优配合比试验研究

采用均匀设计确定树脂混凝土的配合比。根据试验结果运用SPSS进行回归分析,再用MATLAB进行优化,得到树脂混凝土的最优配合比。此方法不但大大减小了试验次数,降低了试验成本,而且为树脂混凝土（聚合物混凝土）在实际工程中的应用提供了一种准确可靠的配合比设计方法。