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1.
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response 总被引:4,自引:0,他引:4
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针对无源电磁调控中目标模拟样式单一且灵活性欠缺的问题,利用有源频率选择表面(active frequency selective surface, AFSS)电磁散射特性可调且不主动辐射电磁波的特性,提出了一种AFSS反射器电磁散射状态切换的双脉冲周期间歇调制方法。构建了AFSS反射器的双脉冲周期间歇调制信号模型,分析了调制信号的特点。通过理论推导,研究了AFSS反射器对雷达线性调频信号回波匹配滤波结果的影响。最后进行了仿真验证,结果证明了所提方法的有效性和可行性。该方法增加了控制参数维度,调制样式更为丰富,应用于雷达目标模拟时可以提高其可变性和灵活性。 相似文献
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用类Lee-Low-Pines中间耦合方法讨论了在有限温度情形极性-极性半导体异质结中界面极化子的性质.在二维近似下,得到了两支界面光学声子模影响下的极化子能量和有效质量的解析表达式.结果表明:极化子效应随温度的升高而减弱,并发现极化子能量较其有效质量对温度更为敏感.数值结果表明温度效应对某些Ⅱ-Ⅵ族半导体异质结是重要的,但对Ⅲ-Ⅴ族半导体异质结是不重要的. 相似文献
6.
Cellular immune response is a major barrier to xenotransplantation. Human tumor necrosis factor-α (hTNF-α) possesses cross-species activity and directly amplifies the immune rejection via the upregulation of adhesion molecules on porcine endothelium. We investigated the role of protein tyrosine phosphorylation in the induction of expression of E-sclectin and vascular cell adhesion molecule-1 (VCAM-1), and the augmentation of adhesion of human peripheral blood monocytes (PBMo) and natural killer cells (PBNK), after rhTNF-α-stimulation of porcine aortic endothelial cells (PAEC) in vitro, rhTNF-α-increased adhesiveness of PAEC for both PBMo and PBNK was dose-dependently reduced by pretreatment of PAEC with the selective protein tyrosine kinase (PTK) inhibitor genistein. The inhibitory effect occurred at the early time of PAEC activation triggered by rhTNF-α, and was completely reversible. PTK activity assay indicated that genistein also suppressed rhTNF-α stimulated activation of protein tyrosine kinases (PTKs) in PAEC in a dose-dependent manner. Flow cytometric analysis showed that genistein inhibited the upregulation of E-selectin and VCAM-1 by rhTNF-α. These results suggest that PTKs may regulate the expression of E-selectin and VCAM-1 on PAEC and the adherence of PBMo and PBNK induced by rhTNF-α. Moreover, dietary genistein, used as an adhesion antagonist, may contribute to managing the cell-mediated rejection in the clinical application. 相似文献
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具有循环中心和小中心商的有限p群 总被引:3,自引:0,他引:3
本文证明中心循环且中心商为p~5阶群的有限p群能分为15个互不同构的类。 相似文献
8.
Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins 总被引:1,自引:0,他引:1
During protein biosynthesis, nascent polypeptide chains that emerge from the ribosomal exit tunnel encounter ribosome-associated chaperones, which assist their folding to the native state. Here we present a 2.7 A crystal structure of Escherichia coli trigger factor, the best-characterized chaperone of this type, together with the structure of its ribosome-binding domain in complex with the Haloarcula marismortui large ribosomal subunit. Trigger factor adopts a unique conformation resembling a crouching dragon with separated domains forming the amino-terminal ribosome-binding 'tail', the peptidyl-prolyl isomerase 'head', the carboxy-terminal 'arms' and connecting regions building up the 'back'. From its attachment point on the ribosome, trigger factor projects the extended domains over the exit of the ribosomal tunnel, creating a protected folding space where nascent polypeptides may be shielded from proteases and aggregation. This study sheds new light on our understanding of co-translational protein folding, and suggests an unexpected mechanism of action for ribosome-associated chaperones. 相似文献
9.
Accurate translation of genetic information into protein sequence depends on complete messenger RNA molecules. Truncated mRNAs cause synthesis of defective proteins, and arrest ribosomes at the end of their incomplete message. In bacteria, a hybrid RNA molecule that combines the functions of both transfer and messenger RNAs (called tmRNA) rescues stalled ribosomes, and targets aberrant, partially synthesized, proteins for proteolytic degradation. Here we report the 3.2-A-resolution structure of the tRNA-like domain of tmRNA (tmRNA(Delta)) in complex with small protein B (SmpB), a protein essential for biological functions of tmRNA. We find that the flexible RNA molecule adopts an open L-shaped conformation and SmpB binds to its elbow region, stabilizing the single-stranded D-loop in an extended conformation. The most striking feature of the structure of tmRNA(Delta) is a 90 degrees rotation of the TPsiC-arm around the helical axis. Owing to this unusual conformation, the SmpB-tmRNA(Delta) complex positioned into the A-site of the ribosome orients SmpB towards the small ribosomal subunit, and directs tmRNA towards the elongation-factor binding region of the ribosome. On the basis of this structure, we propose a model for the binding of tmRNA on the ribosome. 相似文献
10.
<正>Introduction In recent years the production of aluminum alloy has leaped to second place in overall metal material pro-duction, surpassed only by steel. In addition to use in the aviation industry, aluminum alloy has begun to be applied in the machinery manufacturing industry and 相似文献