Prostacyclin-like activity of endothelium and subendothelium — important for atherosclerosis?

Summary Morphological control of Moncada's bioassay for prostacyclin (PG I₂) activity measurement shows that the activity depends not only on endothelium, but in important amounts on subendothelial tissue too. Therefore, it can be concluded that platelet thrombus formation after endothelial cell injury does not depend only on the PG I₂-producing ability of the tissue.     

钙调素特异性拮抗剂(TFP)对大鼠着床的影响

在大鼠孕４ｄ宫腔内一次性注入钙调素特异性拮抗剂－三氟拉嗪,每侧子宫角０．０５ｍＬ,具有显著的抗着床作用,抗着床率高达１００％,而注入等容量生理盐水的对照组为０％。     

An adaptive routing protocol based on relative positions in VANETs

After presenting weaknesses of several classic routing protocols applied in vehicular ad hoc networks (VANETs) by a qualitative comparison,this paper proposes a novel self-adaptive routing protocol,nam...     

A common variant of HMGA2 is associated with adult and childhood height in the general population

Human height is a classic, highly heritable quantitative trait. To begin to identify genetic variants influencing height, we examined genome-wide association data from 4,921 individuals. Common variants in the HMGA2 oncogene, exemplified by rs1042725, were associated with height (P = 4 x 10(-8)). HMGA2 is also a strong biological candidate for height, as rare, severe mutations in this gene alter body size in mice and humans, so we tested rs1042725 in additional samples. We confirmed the association in 19,064 adults from four further studies (P = 3 x 10(-11), overall P = 4 x 10(-16), including the genome-wide association data). We also observed the association in children (P = 1 x 10(-6), N = 6,827) and a tall/short case-control study (P = 4 x 10(-6), N = 3,207). We estimate that rs1042725 explains approximately 0.3% of population variation in height (approximately 0.4 cm increased adult height per C allele). There are few examples of common genetic variants reproducibly associated with human quantitativetraits; these results represent, to our knowledge, the first consistently replicated association with adult and childhood height.     

Stability of the Larsen B ice shelf on the Antarctic Peninsula during the Holocene epoch

The stability of the Antarctic ice shelves in a warming climate has long been discussed, and the recent collapse of a significant part, over 12,500 km2 in area, of the Larsen ice shelf off the Antarctic Peninsula has led to a refocus toward the implications of ice shelf decay for the stability of Antarctica's grounded ice. Some smaller Antarctic ice shelves have undergone periodic growth and decay over the past 11,000 yr (refs 7-11), but these ice shelves are at the climatic limit of ice shelf viability and are therefore expected to respond rapidly to natural climate variability at century to millennial scales. Here we use records of diatoms, detrital material and geochemical parameters from six marine sediment cores in the vicinity of the Larsen ice shelf to demonstrate that the recent collapse of the Larsen B ice shelf is unprecedented during the Holocene. We infer from our oxygen isotope measurements in planktonic foraminifera that the Larsen B ice shelf has been thinning throughout the Holocene, and we suggest that the recent prolonged period of warming in the Antarctic Peninsula region, in combination with the long-term thinning, has led to collapse of the ice shelf.     

An approach for QoS measurement and web service selection sureness

Web services have gained popularity m recent years anu prowue a new moue, u~ w~u, w,,,~,, ,~- cilitates interaction of scientific and business applications through the Internet. More often, several services with similar functionality are available from a large and changing number of service provid- ers. Quality of Service （QoS） is the dominant factor in service selection and is of great importance to users. In this paper, we propose a model for QoS measurement and web services selection. The model consists of QoS model, QoS monitoring, QoS comparison and service selection with a QoS feedback mechanism. The most suitable service is to take into account the agreed QoS, monitoring is done during invocation phase and if any deviation is recorded, next suitable service is selected. Fi- nally the model is proved to be feasible and effective by simulation experiments.     

Genome-wide, large-scale production of mutant mice by ENU mutagenesis

In the post-genome era, the mouse will have a major role as a model system for functional genome analysis. This requires a large number of mutants similar to the collections available from other model organisms such as Drosophila melanogaster and Caenorhabditis elegans. Here we report on a systematic, genome-wide, mutagenesis screen in mice. As part of the German Human Genome Project, we have undertaken a large-scale ENU-mutagenesis screen for dominant mutations and a limited screen for recessive mutations. In screening over 14,000 mice for a large number of clinically relevant parameters, we recovered 182 mouse mutants for a variety of phenotypes. In addition, 247 variant mouse mutants are currently in genetic confirmation testing and will result in additional new mutant lines. This mutagenesis screen, along with the screen described in the accompanying paper, leads to a significant increase in the number of mouse models available to the scientific community. Our mutant lines are freely accessible to non-commercial users (for information, see http://www.gsf.de/ieg/groups/enu-mouse.html).     

分析医学英语词汇和句法特征

医学英语在词汇来源、构词法、被动语态的频繁使用等方面,具有不同于普通英语的词法和句法特征。文章利用实践教学中的经验,归纳和分析了医学英语的词法和句法特征,有利于医学英语的教与学水平的进一步提高。     

Ultra-prolonged activation of CO2-sensing neurons disorients mosquitoes

Carbon dioxide (CO(2)) present in exhaled air is the most important sensory cue for female blood-feeding mosquitoes, causing activation of long-distance host-seeking flight, navigation towards the vertebrate host and, in the case of Aedes aegypti, increased sensitivity to skin odours. The CO(2) detection machinery is therefore an ideal target to disrupt host seeking. Here we use electrophysiological assays to identify a volatile odorant that causes an unusual, ultra-prolonged activation of CO(2)-detecting neurons in three major disease-transmitting mosquitoes: Anopheles gambiae, Culex quinquefasciatus and A. aegypti. Importantly, ultra-prolonged activation of these neurons severely compromises their ability subsequently to detect CO(2) for several minutes. We also identify odours that strongly inhibit CO(2)-sensitive neurons as candidates for use in disruption of host-seeking behaviour, as well as an odour that evokes CO(2)-like activity and thus has potential use as a lure in trapping devices. Analysis of responses to panels of structurally related odours across the three mosquitoes and Drosophila, which have related CO(2)-receptor proteins, reveals a pattern of inhibition that is often conserved. We use video tracking in wind-tunnel experiments to demonstrate that the novel ultra-prolonged activators can completely disrupt CO(2)-mediated activation as well as source-finding behaviour in Aedes mosquitoes, even after the odour is no longer present. Lastly, semi-field studies demonstrate that use of ultra-prolonged activators disrupts CO(2)-mediated hut entry behaviour of Culex mosquitoes. The three classes of CO(2)-response-modifying odours offer powerful instruments for developing new generations of insect repellents and lures, which even in small quantities can interfere with the ability of mosquitoes to seek humans.