Antimicrobial peptides are host defence molecules that play a potential role in preventing infection at the epithelial surfaces.
Ribonuclease (RNase)-7 has been shown to possess a broad spectrum of microbicidal activity against various pathogens. Here,
we demonstrate that RNase-7 protein is localised to the superficial layers of ocular surface cells and increased in response
to interleukin (IL)-1β, suggesting an active role during inflammation related to ocular surface infection. Signal transduction
pathways involved in RNase-7 expression are unknown. Involvement of transforming growth factor β-activated kinase-1 (TAK-1)
activated nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathway molecules [c-Jun N-terminal kinase
(JNK), extracellular signal-regulated kinase (ERK) and p38] were studied because of their importance in infection and inflammation.
Blocking the MAPKs resulted in inhibition of RNase-7 expression in response to IL-1β. However, RNase-7 induction by IL-1β
was not affected by inhibiting the NF-κB signalling pathway. In conclusion, our results indicate that RNase-7 expression is
specifically mediated via MAPKs but not NF-κB signalling pathways. 相似文献
Over the last decade, there has been an exponential growth of services over the Internet. Services such as online gaming are gaining popularity, whereas, Voice over Internet (VoIP) has been well established. Storage, management and processing of data have moved away from the devices to the cloud. Quality of experience (QoE) defined as the user’s perception of service quality is utilized in different technologies, services and products for improving end user satisfaction and provides quality of service (QoS) according to their demands. In this paper, we describe the utilization of QoE in different technologies, services and products for improving end user satisfaction. Specifically, we present the latest developments in QoE in multimedia services, network management, VoIP, web development, games and cloud computing. Finally, we discuss the current research, solutions and present open issues of future research in QoE.