Induction of an illusory shadow person

Stimulation of a site on the brain's left hemisphere prompts the creepy feeling that somebody is close by. The strange sensation that somebody is nearby when no one is actually present has been described by psychiatric and neurological patients, as well as by healthy subjects, but it is not understood how the illusion is triggered by the brain. Here we describe the repeated induction of this sensation in a patient who was undergoing presurgical evaluation for epilepsy treatment, as a result of focal electrical stimulation of the left temporoparietal junction: the illusory person closely 'shadowed' changes in the patient's body position and posture. These perceptions may have been due to a disturbance in the multisensory processing of body and self at the temporoparietal junction.     

Changes in rat erythrocyte membrane induced by delta 1-tetrahydrocannabinol, scanning electron microscope study.

Although some biochemical dose-dependent effects are revealed in erythrocytes exposed to delta 1-tetrahydrocannabinol (THC) already at concentrations well below 10 microM, marked morphological changes of the erythrocyte membrane become evident, by scanning electron microscopy, only at THC concentrations beyond 15 microM. These observations provide evidence additional to previous chemical and physical studies, in which 15 microM is found to be a critical concentration with respect to the effects of TCH on erythrocyte membrane.     

Mavericks and lotteries

In 2013 the Health Research Council of New Zealand began a stream of funding titled ‘Explorer Grants’, and in 2017 changes were introduced to the funding mechanisms of the Volkswagen Foundation ‘Experiment!’ and the New Zealand Science for Technological Innovation challenge ‘Seed Projects’. All three funding streams aim at encouraging novel scientific ideas, and all now employ random selection by lottery as part of the grant selection process. The idea of funding science by lottery emerged independently in several corners of academia, including in philosophy of science. This paper reviews the conceptual and institutional landscape in which this policy proposal emerged, how different academic fields presented and supported arguments for the proposal, and how these have been reflected (or not) in actual policy. The paper presents an analytical synthesis of the arguments presented to date, notes how they support each other and shape policy recommendations in various ways, and where competing arguments highlight the need for further analysis or more data. In addition, it provides lessons for how philosophers of science can engage in shaping science policy, and in particular, highlights the importance of mixing complementary expertise: it takes a (conceptually diverse) village to raise (good) policy.     

Coherent quantum phase slip

A hundred years after the discovery of superconductivity, one fundamental prediction of the theory, coherent quantum phase slip (CQPS), has not been observed. CQPS is a phenomenon exactly dual to the Josephson effect; whereas the latter is a coherent transfer of charges between superconducting leads, the former is a coherent transfer of vortices or fluxes across a superconducting wire. In contrast to previously reported observations of incoherent phase slip, CQPS has been only a subject of theoretical study. Its experimental demonstration is made difficult by quasiparticle dissipation due to gapless excitations in nanowires or in vortex cores. This difficulty might be overcome by using certain strongly disordered superconductors near the superconductor-insulator transition. Here we report direct observation of CQPS in a narrow segment of a superconducting loop made of strongly disordered indium oxide; the effect is made manifest through the superposition of quantum states with different numbers of flux quanta. As with the Josephson effect, our observation should lead to new applications in superconducting electronics and quantum metrology.     

Changes in rat erythrocyte membrane induced byΔ 1-tetrahydrocannabinol,scanning electron microscope study

Summary Although some biochemical dose-dependent effects are revealed in erythrocytes exposed to ¹ (THC) already at concentrations well below 10 M, marked morphological changes of the erythrocyte membrane become evident, by scanning electron microscopy, only at THC concentrations beyound 15 M. These observations provide evidence additional to previous chemical and physical studies, in which 15 M is found to be a critical concentration with respect to the effects of TCH on erythrocyte membrane.Acknowledgments. The authors are indebted to Prof. R. Mechoulam from the School of Pharmacy, The Hebrew University, Jerusalem, for providing the THC. The excellent technical assistance of Mrs R. Mordechai and of Miss L. Motola is gratefully acknowledged.     

Ultrastructural localization of acid phosphatase in the yeastCryptococcus neoformans

Résumé La localisation de la phosphatase-acide dans la levureCryptococcus neoformans est étudiée ici par des méthodes cytochimiques au niveau ultrastructural. On a trouvé que l'enzyme se concentrait exclusivement dans les vacuoles, ce qui s'accorde avec les résultats que d'autres auteurs ont obtenus sur la localisation de l'enzyme dans les cellules végétales.