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本研究采用健康雄性ＳＤ大鼠，青年组（３月龄）２０只，老年组（２６月龄）４０只，通过Ｍｏｒｒｉ水米宫行为学测试，将老年大鼠分为老年记忆减退组（简称老年减退组）和老年记忆正常组（简称老年正常组）。用免疫细胞化学、组织化学双标技术定量分析内侧隔核－斜角带（ｓｅｐｔｕｍ ｍｅｄｉａｌｉｓ－ｄｉａｇｏｎａｌ ｂａｎｄ ｏｆ Ｂｒｏｃａ，ＳＭ－ＤＢ）中神经生长因子受体（ｎｅｒｖｅ ｇｒｏｗｔｈ ｆａｃｔｏｒ 相似文献
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目的：观察补肾益智方对老年性痴呆模型大鼠学习记忆功能障碍的改善作用。方法：采用在Ｄ－半乳糖催佬 基础上加基底前脑注射ＩＢＯ法复制老年性痴呆大鼠模型,用Ｍｏｒｒｉｓ水迷宫法评价补肾益智方对老年性痴呆模型大鼠学习记忆功能障碍的改善作用。结果：补肾益智方组大鼠在Ｍｏｒｒｉｓ水迷宫中,逃避潜伏期明显的平台象限游泳时间明显延长,与模型组比较有显著意义。结论：补肾益智方对模型大鼠学习记忆损害的改善艇明显优于阳 相似文献
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Aim Study on the effect
of BYR on the animal model of alzheimer's disease in rats. Methods The
animal model of Alzheimer's disease was made by D-galactose intraperitoneal injection and
basal forebrain bilateral lesion with ibotenic acid microinjection in rats. Learning and
memory deficits of these rats were assessed in the Morris water maze and treated with BYF.
Results The escape latency of BYF group was significantly shorter than
that of Hup-A group and the model control group. The swimming time in the quadrant contain
platforrn was much longer than that of Hup-A group and model control group. Conclusion
BYF has great effect on the learning and memory deficits of this animal model of
Alzheimer′s disease in rats. 相似文献
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