摩擦焊直接能量控制法的研究

摩擦焊直接能量控制法是一种以摩擦能量为控制对象的闭环控制方法。采用先进的单片机测控及高精度的检测方法，直接检测驱动电机的实时输入功率以获得实时摩擦能量；并以此为闭环控制对象，对焊接过程进行控制，同以往开环控制法相比，克服了工艺参数的波动对接头质量的影响，从而大大减少了焊前工作量；同时也减少也人为因素对接头质量的影响，使焊接质量达到一个新水平。     

导电摩擦焊过程中电流行为的研究

研究了一种新颖的焊接方法－－导电摩擦焊＾［１］，即在摩擦焊过程中向工件通入一定数值的电流，形成复合热源加热。由于电流的引入，增大了摩擦焊规范参数调节范围，对摩擦焊过程中焊接温度场起到很好的调节作用，从而可有效地减少焊接时间，降低主轴功率与扭矩峰值，减少变形量以及改善接头性能等，并对摩擦焊工艺和设备的改进将起一定的作用。     

汲取“文化科学”新成就的卫生和社会教育战略

教育学的发展是一个复杂的过程,它涉及到一个国家的经济和政治政策、社会福利设施及教师、家长与青年学生的相互关系。第二次世界大战结束以来,在教育理论和实践的发展中,一个关键的领域是包括卫生和社会教育的“软课程”(Soft Curriculum)。本文作者提出一种汲取社会科学最新进展的新教育方法。     

扁钢带直流电阻对焊接头变形的研究

研究了扁钢带直流电阻对焊工艺，分析了变形机理．试验结果表明，增大位移门槛电压值或者减小预压力，可增大塑性金属的变形程度，这有利于将杂质从接合界面挤出．     

应用微型剪切试验评定焊接接头的力学性能

该文介绍一种研究金属材料机械性能的新型试验方法－微型剪切试验方法在焊接技术中的应用。该方法简单、省料、试验数据重现性好，尤其适用于定量测定不均匀材料各狭窄区域的性能参数或性能梯度。该文着重研究了用微型剪切法评定ＣＯ２焊接接头各区域性能，并将有关试验结果与常规Ｃｈａｒｐｙ冲击试验结果相比较。对上述两种方法的试验结果经过回归处理，表明剪切强度与Ｃｈａｒｐｙ冲击功之间有较好的对应关系。试验结果初步认为，     

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Mitochondria play a critical role in mediating both apoptotic and necrotic cell death. The mitochondrial permeability transition (mPT) leads to mitochondrial swelling, outer membrane rupture and the release of apoptotic mediators. The mPT pore is thought to consist of the adenine nucleotide translocator, a voltage-dependent anion channel, and cyclophilin D (the Ppif gene product), a prolyl isomerase located within the mitochondrial matrix. Here we generated mice lacking Ppif and mice overexpressing cyclophilin D in the heart. Ppif null mice are protected from ischaemia/reperfusion-induced cell death in vivo, whereas cyclophilin D-overexpressing mice show mitochondrial swelling and spontaneous cell death. Mitochondria isolated from the livers, hearts and brains of Ppif null mice are resistant to mitochondrial swelling and permeability transition in vitro. Moreover, primary hepatocytes and fibroblasts isolated from Ppif null mice are largely protected from Ca2+-overload and oxidative stress-induced cell death. However, Bcl-2 family member-induced cell death does not depend on cyclophilin D, and Ppif null fibroblasts are not protected from staurosporine or tumour-necrosis factor-alpha-induced death. Thus, cyclophilin D and the mitochondrial permeability transition are required for mediating Ca2+- and oxidative damage-induced cell death, but not Bcl-2 family member-regulated death.     

金属材料在微型剪切过程的变形和断裂规律的探讨

通过对三种不同强度等级材料的微型剪切试验和与不同剪切点相对应的剪切面上压延流线的形态以及断口形貌观察和分析，探讨了金属材料在微型剪切过程中的变形和断裂的基础规律。试验结果表明，微型剪切时材料的变形和断裂过程，与常规拉伸试验既有相似之处，又有其固有特征。并初步提出了微型剪切过程中在剪切面附近的应力分布模型。从而为进一步深入研究微型剪切的机理和扩大其在工程技术中的实际应用提供了必要的理论依据。     

Identification of an antimalarial synthetic trioxolane drug development candidate

The discovery of artemisinin more than 30 years ago provided a completely new antimalarial structural prototype; that is, a molecule with a pharmacophoric peroxide bond in a unique 1,2,4-trioxane heterocycle. Available evidence suggests that artemisinin and related peroxidic antimalarial drugs exert their parasiticidal activity subsequent to reductive activation by haem, released as a result of haemoglobin digestion by the malaria-causing parasite. This irreversible redox reaction produces carbon-centred free radicals, leading to alkylation of haem and proteins (enzymes), one of which--the sarcoplasmic-endoplasmic reticulum ATPase PfATP6 (ref. 7)--may be critical to parasite survival. Notably, there is no evidence of drug resistance to any member of the artemisinin family of drugs. The chemotherapy of malaria has benefited greatly from the semi-synthetic artemisinins artemether and artesunate as they rapidly reduce parasite burden, have good therapeutic indices and provide for successful treatment outcomes. However, as a drug class, the artemisinins suffer from chemical (semi-synthetic availability, purity and cost), biopharmaceutical (poor bioavailability and limiting pharmacokinetics) and treatment (non-compliance with long treatment regimens and recrudescence) issues that limit their therapeutic potential. Here we describe how a synthetic peroxide antimalarial drug development candidate was identified in a collaborative drug discovery project.     

黝铜矿族矿物的EPMA研究

黝铜矿族矿物成分复杂、类质同象取代广泛,种属区分困难。利用EPMA法对该族矿物进行成分分析和图相分析可将其划分为两个亚种、若干个变种。对该族矿的鉴别与研究卓有成效。