Conformational Changes in HL60 Cells during Differentiation and Apoptosis Induced by Genistein

IntroductionGenistein is a naturally occurring phytoestrogenpresent in a variety of plant foods,includingsoybean[1] .It is known to inhibit both tyrosineprotein kinases and DNA topoisomerase II.Akiyama et al.[2 ] described the ability of genisteinto specifically inhibit protein tyrosine kinase( PTKs) ,presumably at the level of the ATPbinding site.PTKs seem to play a key role intumorigenesis and are known to be associated withgrowth control receptors such as epidermal growthfactors[3] ,p…     

Paul势阱中两带电粒子的暂态混沌

从耦合ＭａｔｈｉｅｕＣｏｕｌｏｍｂ方程出发,用数值方法研究了Ｐａｕｌ势阱中两个带电粒子的暂态行为,发现平均暂态寿命随势阱电压的增加而指数增加,或随阻尼系数的增加而指数减小．在这个耗散系统中不存在永久混沌,暂态混沌是吸引子出现之前系统普遍存在的行为     

破解资源紧缺制约瓶颈建立循环经济产业链

本文重点研究分析汉中锌业特材、中材汉江水泥、府谷兰炭尾气作燃料冶炼金属镁等企业，引进先进生产工艺和设备，发展循环经济清洁生产，改变传统经济增长模式。使资源循环利用，减少废弃物排放，达到合理利用资源和环境容量，破解了资源紧缺制约瓶颈，保护生态环境，实现经济提质增效发展。     

基因组研究--多学科的交叉和相互启发

生命的产生以基因组提供的信息为基础,所有的生命活动都与基因组息息相关.人类基因组由30亿碱基对构成.人类基因组计划首先是要揭示人类基因组的序列结构,即弄清这么多的碱基按什么顺序串联在一起;接着是弄清各段序列都有什么生物功能,如哪些序列能编码蛋白质或功能PNA,哪些序列是基因表达的正、负调控序列,哪些是基因表达的启动序列、终止序列等,这部分工作称为结构基因组研究;最终要弄清基因组的各部分是如何工作,尤其是如何分工协作的,这称为功能基因组研究.     

Effects of Dioscin Extracted from Polygonatum Zanlanscianense Pamp on Several Human Tumor Cell Lines

IntroductionPolygonatum Zanlanscianense Pamp grows insoutheastern Gansu and southwestern Shaanxi,China.Its roots are used as a substitute for“Yuzhu”,a famous traditional Chinese medicinethat has long been used in the treatment of lungillnesses,palpitation,upset stomach anddiabetes[12 ] .A literature survey showed thatseveral Polygonatum species have already beenchemically studied and found to contain steroidalsaponins[3 5] .However,there are no reports on thechemical properties of Polygo…