石杉碱甲片联合丁苯酞软胶囊对轻度阿尔茨海默病患者认知功能的疗效观察

目的 评价石杉碱甲片联合丁苯酞软胶囊对阿尔茨海默病患者认知功能的临床疗效.方法 将100例轻度阿尔茨海默病(Alzheimer's disease,AD)患者随机分为石杉碱甲片联合丁苯酞软胶囊组(治疗组)及单独应用石杉碱甲组(对照组).治疗前及治疗90 d后分别评价两组患者简易智力状态检查(Mini-mental St...     

An efficient multi-locus mixed-model approach for genome-wide association studies in structured populations

Population structure causes genome-wide linkage disequilibrium between unlinked loci, leading to statistical confounding in genome-wide association studies. Mixed models have been shown to handle the confounding effects of a diffuse background of large numbers of loci of small effect well, but they do not always account for loci of larger effect. Here we propose a multi-locus mixed model as a general method for mapping complex traits in structured populations. Simulations suggest that our method outperforms existing methods in terms of power as well as false discovery rate. We apply our method to human and Arabidopsis thaliana data, identifying new associations and evidence for allelic heterogeneity. We also show how a priori knowledge from an A. thaliana linkage mapping study can be integrated into our method using a Bayesian approach. Our implementation is computationally efficient, making the analysis of large data sets (n > 10,000) practicable.     

面向空间管控的村庄分类方法与实践——以天津市武清区为例

针对村庄分类实践中普遍存在与空间管控需求衔接不紧密, 影响规划上下传导有效性的问题, 基于实用性原则, 探讨如何分步对接空间管控与用途管制要求。在此基础上, 结合村庄发展潜力评价结果以及多轮上下联动组织方式, 形成兼顾实际管控需求和村民发展诉求的村庄类型谱系与分类路径, 并以天津市武清区622个村庄为例开展实证研究。     

Fluorometrische bestimmung von mikromengen calcium in muskelgewebe

Summary A method for fluorometric estimation of micro-amounts of calcium (about 10 nEq./sample) in biological materials using calcein as indicator. Its applicability to heart muscle specimens (6–100 mg wet weight) and its limitation by interfering substances are described.     

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

B-cell antigen receptor (BCR) expression is an important feature of chronic lymphocytic leukaemia (CLL), one of the most prevalent B-cell neoplasias in Western countries. The presence of stereotyped and quasi-identical BCRs in different CLL patients suggests that recognition of specific antigens might drive CLL pathogenesis. Here we show that, in contrast to other B-cell neoplasias, CLL-derived BCRs induce antigen-independent cell-autonomous signalling, which is dependent on the heavy-chain complementarity-determining region (HCDR3) and an internal epitope of the BCR. Indeed, transferring the HCDR3 of a CLL-derived BCR provides autonomous signalling capacity to a non-autonomously active BCR, whereas mutations in the internal epitope abolish this capacity. Because BCR expression was required for the binding of secreted CLL-derived BCRs to target cells, and mutations in the internal epitope reduced this binding, our results indicate a new model for CLL pathogenesis, with cell-autonomous antigen-independent signalling as a crucial pathogenic mechanism.     

多平台数据融合系统的航迹关联技术

对于多平台数据融合模式下的航迹关联问题,使用了聚类关联的方法进行解决.采用基于地心坐标系的最小二乘方法对航迹数据进行配准,对航迹间的距离使用Hausdorff距离进行衡量.使用了K-均值算法对各平台侦测的航迹进行关联,并将初始聚类中心设定为相距最远的航迹,有效降低了经典K-均值算法过于依赖初始聚类点带来的错误.仿真数据证实,能在目标密度大且航迹存在交错的场景下保持较高的关联正确率,具有较好的可用性.     

非负张量谱半径上下界的估计不等式

通过张量分析,给出一个具有一般形式的非负张量谱半径的上下界估计不等式,在特别情况下改进了相关非负张量谱半径的估计不等式.     

中学学区对周边小区二手房房价的溢价分析 ——以深圳市为例

选取深圳市3个主要城区185个居住小区的数据, 从中学质量(省级或非省级中学)的维度进行量化建立特征价格模型, 研究深圳市中学教育设施对房价资本化程度的影响。结果表明, 在影响中学周边小区二手房房价的因素中, 学校特征因素有显著的影响, 其中升学率、本硕以上教师和重点学校有正向助推作用, 而生师比有负向抑制作用。影响省级中学和非省级中学周边房价的学校特征因素存在差异, 其中在非省级中学周边小区二手房房价中, 主要是升学率和生师比等特征的影响, 而在省级中学周边小区二手房房价中, 主要是本硕以上教师人数和生师比等特征影响。与地铁和CBD的距离以及楼龄对中学周边房价表现为负影响, 且与重大商业服务中心和地铁站距离每增加1 km, 房价分别下降13.9%和28.7%, 楼龄每增加1年, 房价下降6.8%。研究结果揭示了中学教育质量特征对住宅价格的影响及程度, 综合反映了深圳市中学学区房价格的影响机制。     

无人机与车辆协助下的分布式多任务边缘计算卸载算法

为满足密集分布用户的服务质量和体验质量,建立了车辆和无人机协助下的多接入边缘计算卸载模型,车辆、无人机和路边单元作为边缘节点,将不同的计算任务按需卸载到不同类型的边缘节点进行处理.设计了基于分布式匹配-贪婪算法的终端用户任务卸载方案以最小化系统功耗,并研究了用户数量和延迟容忍对卸载方案的影响.仿真结果表明:该方案在满足...