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1.
Systemic Intervention in a University Department: Reflections on Arrested Action Research 总被引:1,自引:1,他引:0
Don Houston 《Systemic Practice and Action Research》2008,21(2):133-152
This paper reflects on my experience as an insider researcher attempting to use critical systems ideas and practices to promote
quality improvement in a university engineering department. Reflection is a key part of learning. This paper is intended to
contribute to critically, self-reflective learning for the community of systems practitioners. These reflections on my questions
about participation, ethics, politics of process, and the choices and actions resulting from them may help others to formulate
their own. The complexity of systems practice places substantial demands on the researcher, particularly in the case of insider,
practitioner research. Nevertheless, the exploration of critical systems approaches to critique boundaries and structure ‘problems’
in the core aspects of higher education in locally meaningful ways should continue. While demanding, it still can work to
promote learning about authentic quality. 相似文献
2.
对比研究显示食管癌高发区磁县土壤,粮食,水和正常人发硒的质量分数「分别为0.42*10^-9,0.08*10^-9,1.24*10^-9,1.16*10^-6」最高,中发区临漳县次之「分别为0.174*10^-9,0.049*10^-9,0.68*10^-9,0.97*10^-6」,低发区魏县最低「分别为0.148*10^-9,0.026*10^-9,0.24*10^-9,0.91*10^-6」, 相似文献
3.
DonL.Anderson 《科学通报(英文版)》2004,49(19):2017-2020
Scaling relations are important in extrapolating laboratory experiments to the Earth‘s mantle. In planetary interiors, compression becomes an important parameter and it is useful to explore scalings that involve volume. I use simple volume scaling relations that allow one to extrapolate laboratory experiments and upper mantle behavior, in a thermodynamically self-consistent way, to predict lower mantle behavior. The relations are similar to the quasi-har-monic approximation. Slabs and plates have characteristic dimensions of hundreds of kilometers and time constants of 100 million years, but the volume scalings predict order of magnitude higher values in the deep mantle. The scaling relations imply that the deep mantle is a sluggish system with ancient features. They imply irreversible chemical stratification and do not favor the plume hypothesis. 相似文献
4.
Oxysterols direct immune cell migration via EBI2 总被引:1,自引:0,他引:1
Hannedouche S Zhang J Yi T Shen W Nguyen D Pereira JP Guerini D Baumgarten BU Roggo S Wen B Knochenmuss R Noël S Gessier F Kelly LM Vanek M Laurent S Preuss I Miault C Christen I Karuna R Li W Koo DI Suply T Schmedt C Peters EC Falchetto R Katopodis A Spanka C Roy MO Detheux M Chen YA Schultz PG Cho CY Seuwen K Cyster JG Sailer AW 《Nature》2011,475(7357):524-527
Epstein-Barr virus-induced gene 2 (EBI2, also known as GPR183) is a G-protein-coupled receptor that is required for humoral immune responses; polymorphisms in the receptor have been associated with inflammatory autoimmune diseases. The natural ligand for EBI2 has been unknown. Here we describe the identification of 7α,25-dihydroxycholesterol (also called 7α,25-OHC or 5-cholesten-3β,7α,25-triol) as a potent and selective agonist of EBI2. Functional activation of human EBI2 by 7α,25-OHC and closely related oxysterols was verified by monitoring second messenger readouts and saturable, high-affinity radioligand binding. Furthermore, we find that 7α,25-OHC and closely related oxysterols act as chemoattractants for immune cells expressing EBI2 by directing cell migration in vitro and in vivo. A critical enzyme required for the generation of 7α,25-OHC is cholesterol 25-hydroxylase (CH25H). Similar to EBI2 receptor knockout mice, mice deficient in CH25H fail to position activated B cells within the spleen to the outer follicle and mount a reduced plasma cell response after an immune challenge. This demonstrates that CH25H generates EBI2 biological activity in vivo and indicates that the EBI2-oxysterol signalling pathway has an important role in the adaptive immune response. 相似文献
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van de Laar IM Oldenburg RA Pals G Roos-Hesselink JW de Graaf BM Verhagen JM Hoedemaekers YM Willemsen R Severijnen LA Venselaar H Vriend G Pattynama PM Collée M Majoor-Krakauer D Poldermans D Frohn-Mulder IM Micha D Timmermans J Hilhorst-Hofstee Y Bierma-Zeinstra SM Willems PJ Kros JM Oei EH Oostra BA Wessels MW Bertoli-Avella AM 《Nature genetics》2011,43(2):121-126
Thoracic aortic aneurysms and dissections are a main feature of connective tissue disorders, such as Marfan syndrome and Loeys-Dietz syndrome. We delineated a new syndrome presenting with aneurysms, dissections and tortuosity throughout the arterial tree in association with mild craniofacial features and skeletal and cutaneous anomalies. In contrast with other aneurysm syndromes, most of these affected individuals presented with early-onset osteoarthritis. We mapped the genetic locus to chromosome 15q22.2-24.2 and show that the disease is caused by mutations in SMAD3. This gene encodes a member of the TGF-β pathway that is essential for TGF-β signal transmission. SMAD3 mutations lead to increased aortic expression of several key players in the TGF-β pathway, including SMAD3. Molecular diagnosis will allow early and reliable identification of cases and relatives at risk for major cardiovascular complications. Our findings endorse the TGF-β pathway as the primary pharmacological target for the development of new treatments for aortic aneurysms and osteoarthritis. 相似文献
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应用铸态淬火研究了碳量(2.5~4.0%)、硅量(2.5~3.5%)、锰量(0.5~5.5%) 对球墨铸铁组织与性能的影响。结果表明,锰含量增加。试样中针状组织减少,残余奥氏体 增 多、碳化物也增多.低硅时锰对碳化物数量、中硅时锰对残余奥氏体数量影响突出。针状组织数 量及针状组织含碳量对硬度影响较大。适当的碳量可使试样中石墨球、碳化物、针状组织有较佳 的配合,具有较好的综合机械性能。 相似文献
10.
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana 总被引:21,自引:0,他引:21
Lin X Kaul S Rounsley S Shea TP Benito MI Town CD Fujii CY Mason T Bowman CL Barnstead M Feldblyum TV Buell CR Ketchum KA Lee J Ronning CM Koo HL Moffat KS Cronin LA Shen M Pai G Van Aken S Umayam L Tallon LJ Gill JE Adams MD Carrera AJ Creasy TH Goodman HM Somerville CR Copenhaver GP Preuss D Nierman WC White O Eisen JA Salzberg SL Fraser CM Venter JC 《Nature》1999,402(6763):761-768
Arabidopsis thaliana (Arabidopsis) is unique among plant model organisms in having a small genome (130-140 Mb), excellent physical and genetic maps, and little repetitive DNA. Here we report the sequence of chromosome 2 from the Columbia ecotype in two gap-free assemblies (contigs) of 3.6 and 16 megabases (Mb). The latter represents the longest published stretch of uninterrupted DNA sequence assembled from any organism to date. Chromosome 2 represents 15% of the genome and encodes 4,037 genes, 49% of which have no predicted function. Roughly 250 tandem gene duplications were found in addition to large-scale duplications of about 0.5 and 4.5 Mb between chromosomes 2 and 1 and between chromosomes 2 and 4, respectively. Sequencing of nearly 2 Mb within the genetically defined centromere revealed a low density of recognizable genes, and a high density and diverse range of vestigial and presumably inactive mobile elements. More unexpected is what appears to be a recent insertion of a continuous stretch of 75% of the mitochondrial genome into chromosome 2. 相似文献