排序方式: 共有42条查询结果,搜索用时 15 毫秒
1.
对圆柱形建筑双幕墙进行了风洞试验,着重分析了不同分隔形式的圆弧双幕墙的风载特性.结果表明:圆弧双幕墙的内幕墙各部位的风荷载比较一致,且随着圆心角的减小,内幕墙所承受的风荷载增大;圆弧双幕墙的外幕墙各部位的风荷载分布则很不均匀,圆弧端部区域的风荷载比圆弧中间区域的大,且由于外幕墙端部测点的内外压随风向角变化不同步,存在相位差,导致了其净风压比单层幕墙的风荷载还大,这在双幕墙的抗风设计中应特别注意. 相似文献
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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 总被引:14,自引:0,他引:14
van Heel DA Franke L Hunt KA Gwilliam R Zhernakova A Inouye M Wapenaar MC Barnardo MC Bethel G Holmes GK Feighery C Jewell D Kelleher D Kumar P Travis S Walters JR Sanders DS Howdle P Swift J Playford RJ McLaren WM Mearin ML Mulder CJ McManus R McGinnis R Cardon LR Deloukas P Wijmenga C 《Nature genetics》2007,39(7):827-829
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. 相似文献
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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants 总被引:2,自引:0,他引:2
Wellcome Trust Case Control Consortium;Australo-Anglo-American Spondylitis Consortium 《Nature genetics》2007,39(11):1329-1337
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. 相似文献
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提出了一种无功线性规划模型与安全校正相结合的无功优化方法。在校正过程中,用准状态变量违界约束搜索控制变量的方法以优化可行控制域。 相似文献
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探讨了硼烷拓扑系数的结构关系一些规律,提出在BnHn+4型硼烷分子(n=4 ̄10)拓扑结构中,具有相同数目的氢桥键和B-B键,不存在-BH2基因,分子拓扑结构主要决定于闭合三中心键数目,对Lipscomb的拓扑理论进行了拓展,提出了稠合B-B键的概念,采用五元组数(s x y t z)来描述硼烷分子的拓扑指数和结构。拓展后的拓扑理论适用于BnHn+4型HnHn+6型的低级硼烷和高级硼烷。 相似文献
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Summary
Agrobacterium tumefaciens A208 with nopaline plasmid pTiT37 was used to obtain stem tumors on plantlets ofFagraea fragrans grown in vitro. Bacterial elimination and tissue proliferation were simultaneously achieved by growing tumors on cefatoxime medium. After some tissue growth the shoots regenerated. An examination of these showed the presence of nopaline, indicating genetic transformation by T-DNA. 相似文献
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Genome-wide strategies for detecting multiple loci that influence complex diseases 总被引:25,自引:0,他引:25
After nearly 10 years of intense academic and commercial research effort, large genome-wide association studies for common complex diseases are now imminent. Although these conditions involve a complex relationship between genotype and phenotype, including interactions between unlinked loci, the prevailing strategies for analysis of such studies focus on the locus-by-locus paradigm. Here we consider analytical methods that explicitly look for statistical interactions between loci. We show first that they are computationally feasible, even for studies of hundreds of thousands of loci, and second that even with a conservative correction for multiple testing, they can be more powerful than traditional analyses under a range of models for interlocus interactions. We also show that plausible variations across populations in allele frequencies among interacting loci can markedly affect the power to detect their marginal effects, which may account in part for the well-known difficulties in replicating association results. These results suggest that searching for interactions among genetic loci can be fruitfully incorporated into analysis strategies for genome-wide association studies. 相似文献
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Hasegawa H Fujimoto M Phan TD Rème H Balogh A Dunlop MW Hashimoto C Tandokoro R 《Nature》2004,430(7001):755-758
Establishing the mechanisms by which the solar wind enters Earth's magnetosphere is one of the biggest goals of magnetospheric physics, as it forms the basis of space weather phenomena such as magnetic storms and aurorae. It is generally believed that magnetic reconnection is the dominant process, especially during southward solar-wind magnetic field conditions when the solar-wind and geomagnetic fields are antiparallel at the low-latitude magnetopause. But the plasma content in the outer magnetosphere increases during northward solar-wind magnetic field conditions, contrary to expectation if reconnection is dominant. Here we show that during northward solar-wind magnetic field conditions-in the absence of active reconnection at low latitudes-there is a solar-wind transport mechanism associated with the nonlinear phase of the Kelvin-Helmholtz instability. This can supply plasma sources for various space weather phenomena. 相似文献