全文获取类型
收费全文 | 16916篇 |
免费 | 34篇 |
国内免费 | 38篇 |
专业分类
系统科学 | 74篇 |
丛书文集 | 263篇 |
教育与普及 | 30篇 |
理论与方法论 | 77篇 |
现状及发展 | 8027篇 |
研究方法 | 720篇 |
综合类 | 7635篇 |
自然研究 | 162篇 |
出版年
2013年 | 78篇 |
2012年 | 195篇 |
2011年 | 380篇 |
2010年 | 76篇 |
2008年 | 236篇 |
2007年 | 256篇 |
2006年 | 291篇 |
2005年 | 283篇 |
2004年 | 387篇 |
2003年 | 261篇 |
2002年 | 258篇 |
2001年 | 479篇 |
2000年 | 443篇 |
1999年 | 326篇 |
1992年 | 286篇 |
1991年 | 221篇 |
1990年 | 238篇 |
1989年 | 235篇 |
1988年 | 202篇 |
1987年 | 234篇 |
1986年 | 278篇 |
1985年 | 335篇 |
1984年 | 230篇 |
1983年 | 226篇 |
1982年 | 205篇 |
1981年 | 217篇 |
1980年 | 224篇 |
1979年 | 563篇 |
1978年 | 475篇 |
1977年 | 437篇 |
1976年 | 341篇 |
1975年 | 404篇 |
1974年 | 565篇 |
1973年 | 453篇 |
1972年 | 472篇 |
1971年 | 553篇 |
1970年 | 697篇 |
1969年 | 539篇 |
1968年 | 539篇 |
1967年 | 536篇 |
1966年 | 431篇 |
1965年 | 372篇 |
1964年 | 121篇 |
1959年 | 193篇 |
1958年 | 330篇 |
1957年 | 247篇 |
1956年 | 190篇 |
1955年 | 192篇 |
1954年 | 190篇 |
1948年 | 127篇 |
排序方式: 共有10000条查询结果,搜索用时 52 毫秒
1.
Lamine Alaoui Gustavo Palomino Sandy Zurawski Gerard Zurawski Sixtine Coindre Nathalie Dereuddre-Bosquet Camille Lecuroux Cecile Goujard Bruno Vaslin Christine Bourgeois Pierre Roques Roger Le Grand Olivier Lambotte Benoit Favier 《Cellular and molecular life sciences : CMLS》2018,75(10):1871-1887
Classical dendritic cells (cDCs) play a pivotal role in the early events that tip the immune response toward persistence or viral control. In vitro studies indicate that HIV infection induces the dysregulation of cDCs through binding of the LILRB2 inhibitory receptor to its MHC-I ligands and the strength of this interaction was proposed to drive disease progression. However, the dynamics of the LILRB2/MHC-I inhibitory axis in cDCs during early immune responses against HIV are yet unknown. Here, we show that early HIV-1 infection induces a strong and simultaneous increase of LILRB2 and MHC-I expression on the surface of blood cDCs. We further characterized the early dynamics of LILRB2 and MHC-I expression by showing that SIVmac251 infection of macaques promotes coordinated up-regulation of LILRB2 and MHC-I on cDCs and monocytes/macrophages, from blood and lymph nodes. Orientation towards the LILRB2/MHC-I inhibitory axis starts from the first days of infection and is transiently induced in the entire cDC population in acute phase. Analysis of the factors involved indicates that HIV-1 replication, TLR7/8 triggering, and treatment by IL-10 or type I IFNs increase LILRB2 expression. Finally, enhancement of the LILRB2/MHC-I inhibitory axis is specific to HIV-1 and SIVmac251 infections, as expression of LILRB2 on cDCs decreased in naturally controlled chikungunya virus infection of macaques. Altogether, our data reveal a unique up-regulation of LILRB2 and its MHC-I ligands on cDCs in the early phase of SIV/HIV infection, which may account for immune dysregulation at a critical stage of the anti-viral response. 相似文献
2.
杨建荣 《科技情报开发与经济》2004,14(6):157-158
根据我国当前电力系统运行情况,对电网无功功率补偿的必要性及通用补偿方法及其装置进行了具体阐述。 相似文献
3.
董文伟 《科技情报开发与经济》2004,14(6):296-297
以具体工程为例,介绍了建筑物地基处理的设计、施工中遵循的原则,施工中遇到特殊情况时采取的处理方法和必要的检测方法,对几种桩基的设计要求、施工工艺及过程、质量控制等情况进行了简单阐述。 相似文献
4.
王永红 《科技情报开发与经济》2004,14(6):139-141
通过1998年、2000年的试验研究,系统分析了顶凌覆盖技术在高寒区节水增温保温、增产增收的机理及其应用效果。提出该技术可以缓解低温干旱特别是春旱对农业生产的困扰,是一项可以抗旱保春播增产增收的实用技术,在高寒地区具有较高的推广价值。 相似文献
5.
1 Results Oxy-apatite materials are thought as zirconia-substitutes in Solid Oxide Fuel Cells due to their fast ionic conduction. However, the well known difficulties related to their densification prevent them from being used as such. This study presents strategies to obtain oxy-apatite dense materials and the influence of elaboration route on transport properties. Particular emphasis is put on the microstructure effect on ion conduction. By the combined use of freeze-drying and conventional or spark p... 相似文献
6.
In agglomerative hierarchical clustering, pair-group methods suffer from a problem of non-uniqueness when two or more distances
between different clusters coincide during the amalgamation process. The traditional approach for solving this drawback has
been to take any arbitrary criterion in order to break ties between distances, which results in different hierarchical classifications
depending on the criterion followed. In this article we propose a variable-group algorithm that consists in grouping more
than two clusters at the same time when ties occur. We give a tree representation for the results of the algorithm, which
we call a multidendrogram, as well as a generalization of the Lance andWilliams’ formula which enables the implementation of the algorithm in a recursive
way.
The authors thank A. Arenas for discussion and helpful comments. This work was partially supported by DGES of the Spanish
Government Project No. FIS2006–13321–C02–02 and by a grant of Universitat Rovira i Virgili. 相似文献
7.
8.
9.
10.