车削功率约束适应数字控制系统的研究

本文介绍一种在普通车床上建立的以TP801-Z80单板机为控制主机的车削过程功率约束型适应数字控制系统,阐述系统的结构设计、分析系统的控制性能以及管理程序设计框图。通过切削试验说明:这种系统有助于充分发挥机床的加工能力,提高机床功率利用率和节约能源。     

面向海上移动目标的空天协同连续观测模型

由于视距限制,对海上移动目标进行连续观测与定位探测难度较大.现有方法通过卫星和无人机等单平台对目标进行观测,不能解决面向海上移动目标连续观测的问题.针对当前单个平台的不足,本文构建了面向海上移动目标的空天协同连续观测模型,并提出了空天协同连续观测策略.空天协同连续观测策略抽取出卫星规划、无人机飞行计划、观测序列、区域预测以及路径规划等五个子问题,并对其进行建模求解.仿真实验表明,该方法大大降低了目标的平均观测周期,有效解决了海上移动目标连续观测问题.     

The methodology of quantitative assess economic output of climate change

A method is introduced in this paper to study the effect of future climatic change on the economy. The researchers determine the economic output of climate change from historical data, and provide a method to quantitatively predict economic output of climate change by an economic-climatic model. A historical reciprocating examination is used to analyze output data for various crops in eight agricultural areas in China and meteorological data from 160 observatories in China from 1980 to 2000. The results show that the methods used are reasonable to a certain extent and good in application.     

热害矿井气流与围岩热交换的数值模拟

为了研究热害矿井中的气流与围岩热交换问题,基于热力学理论建立了气流与围岩热交换的数学模型,并采用METLAB对数学模型进行求解。计算和实验对比结果表明,在通常情况下闹岩中温度场和温度矢量的分布是对称的,气流速度会明显影响温度的分布．但不会改变温度场的对称分布状态。巷道的温度会随着气流速度的增加而降低,但并没有急剧减小,因此风速的确定应与矿井通风相结合。     

Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2

Important to the function of calpains is temporal and spatial regulation of their proteolytic activity. Here, we demonstrate that cytoplasm-resident calpain 2 cleaves human nuclear topoisomerase I (hTOP1) via Ca²⁺-activated proteolysis and nucleoplasmic shuttling of proteases. This proteolysis of hTOP1 was induced by either ionomycin-caused Ca²⁺ influx or addition of Ca²⁺ in cellular extracts. Ca²⁺ failed to induce hTOP1 proteolysis in calpain 2-knockdown cells. Moreover, calpain 2 cleaved hTOP1 in vitro. Furthermore, calpain 2 entered the nucleus upon Ca²⁺ influx, and calpastatin interfered with this process. Calpain 2 cleavage sites were mapped at K¹⁵⁸ and K¹⁸³ of hTOP1. Calpain 2-truncated hTOP1 exhibited greater relaxation activity but remained able to interact with nucleolin and to form cleavable complexes. Interestingly, calpain 2 appears to be involved in ionomycin-induced protection from camptothecin-induced cytotoxicity. Thus, our data suggest that nucleocytoplasmic shuttling may serve as a novel type of regulation for calpain 2-mediated nuclear proteolysis.     

Kinetic study on the reaction between CO2-CO and wustite using the isotope exchange method

To investigate the reaction between CO₂-CO and wustite using the isotope exchange method at 1073, 1173, 1273, and 1373 K, the experiment apparatus was designed to simulate the fluidized bed. The chemical rate constant was estimated by considering the effect of gas phase mass transfer on the reaction. It is found that the chemical rate constant is inversely decreased with the increase in the ratio of CO₂/CO by volume. The activation energy of reaction is in a linear relationship with the ratio of CO₂/CO by volume, and the average activation energy is 155.37 kJ/mol.     

Testing for the usefulness of forecasts

Ashley (Journal of Forecasting 1983; 2 (3): 211–223) proposes a criterion (known as Ashley's index) to judge whether the external macroeconomic variables are well forecast to serve as explanatory variables in forecasting models, which is crucial for policy makers. In this article, we try to extend Ashley's work by providing three testing procedures, including a ratio‐based test, a difference‐based test, and the Bayesian approach. The Bayesian approach has the advantage of allowing the flexibility of adapting all possible information content within a decision‐making environment such as the change of variable's definition due to the evolving system of national accounts. We demonstrate the proposed methods by applying six macroeconomic forecasts in the Survey of Professional Forecasters. Researchers or practitioners can thus formally test whether the external information is helpful. Copyright © 2010 John Wiley & Sons, Ltd.     

无污染脱氧过程中外电路电压与熔池中氧含量的关系

为了解固体电解质脱氧的内部机理,对氧化锆固体电解质电池短路脱氧过程中的外电路电压随时间的变化进行了研究.通过电池电动势与时间关系的数学模型,得出外电路电压与熔池中氧含量的关系,从而根据外电路电压可以预测脱氧反应进行的程度.结果表明,实验数据与模型结果一致.     

Large-scale low-frequency rainfall regimes and their transition modes in summertime over China

It is well known that the predictable period of daily weather is generally within 2-3 weeks, so spatio-temporal mean predictands have to be employed in the monthly, seasonal, and annual predictions. At present, rainfall patterns (RPs)[1-5] are the key for…     

Steady-state kinetic studies with the polysulfonate U-9843, an HIV reverse transcriptase inhibitor

The tetramer of ethylenesulfonic acid (U-9843) is a potent inhibitor of HIV-1 RT^* and possesses excellent antiviral activity at nontoxic doses in HIV-1 infected lymphocytes grown in tissue culture. Kinetic studies of the HIV-1 RT-catalyzed RNA-directed DNA polymerase activity were carried out in order to determine if the inhibitor interacts with the template: primer or the deoxyribonucleotide triphosphate (dNTP) binding sites of the polymerase. Michaelis-Menten kinetics, which are based on the establishment of a rapid equilibrium between the enzyme and its substrates, proved inadequate for the analysis of the experimental data. The data were thus analyzed using steady-state Briggs-Haldane kinetics assuming that the template:primer binds to the enzyme first, followed by the binding of the dNTP and that the polymerase is a processive enzyme. Based on these assumptions, a velocity equation was derived which allows the calculation of all the specific forward and backward rate constants for the reactions occurring between the enzyme, its substrates and the inhibitor. The calculated rate constants are in agreement with this model and the results indicated that U-9843 acts as a noncompetitive inhibitor with respect to both the template:primer and dNTP binding sites. Hence, U-9843 exhibits the same binding affinity for the free enzyme as for the enzyme-substrate complexes and must inhibit the RT polymerase by interacting with a site distinct from the substrate binding sites. Thus, U-9843 appears to impair an event occurring after the formation of the enzyme-substrate complexes, which involves either an event leading up to the formation of the phosphoester bond, the formation of the ester bond itself or translocation of the enzyme relative to its template:primer following the formation of the ester bond.