西方政府改革与管理模式转换

介绍了当代西方国家面临困境而进行改革的四种模式以及传统模式与后层级制之间的区别，提出了借鉴西方国家的教训和经验，改革我国政府管理的设想。     

运用遗传算法的深亚微米输出缓冲器优化设计方法

分析了小尺寸效应对深亚微米器件性能的影响，结合输入输出耦合电容和漏极扩散层寄生电容对CMOS反相器延迟影响很大的特点，建立了小尺寸器件延时估算模型．采用变尺寸率反相器级连方法，建立了深亚微米输出缓冲器优化设计模型，并运用遗传算法建立了新的优化方法．该方法利用罚函数将小尺寸输出缓冲器优化问题转化为无约束问题，通过适应度函数设计和染色体编码，得到遗传优化结果，克服了传统方法处理非线性多变量问题时存在的效率降低等缺陷．SPICE仿真表明，应用新的深亚微米缓冲器设计模型及方法的优化结果与传统设计比较，延时减少了1个数量级以上，尺寸减小了30%以上，验证了新的深亚微米缓冲器设计模型及设计方法的可靠性．     

中小型变电所两级分布式微机监测管理系统

阐述了中小型企业变电所两级分布式微机监测管理系统的构成，配置以及系统总体方案的设计与管理程序系统功能，讨论了利用感应式电度表采集电度值的数据采集系统，说明了具体实现方法。     

单一颗粒流分形模型及有效热导率计算

首次提出了颗粒流中粒子的分形模型，得到粒子在不同分维下的分形分布，并和麦克斯韦分布进行比较，分析了两种分布产生差异的物理机制．在此基础上研究了单一颗粒流的有效热导率，得到其解析表达式，并分析了有效热导率随粒子温度、粒子分维的变化规律．     

船闸闸室灌泄水过程非稳定渗流特性

为了研究船闸闸室在非均质成层地基、灌泄水条件下的非稳定渗流特性,根据渗流基本理论,将渗流分为固结渗流与瞬时稳定渗流。以工程实例为依托,利用有限元软件ABAQUS建立二维渗流模型,模拟船闸灌泄水过程,考虑流固耦合,分析非稳定渗流特性及影响。结果表明,随着灌泄水的周期性变化,测压管水位存在周期性、衰减性与滞后性;在灌泄水过程中,存在泄水、灌水速度零点;泄水末期,非稳定渗流计算的渗透应力沿高程均大于低水稳定渗流计算值,渗透稳定系数降低,发生渗透破坏的可能性加大。因此,在船闸防渗设计中应充分考虑非稳定渗流场的影响。     

非扩张半群公共不动点与广义变分不等式 解的迭代收敛性

引入一种新的非扩张半群显式粘滞迭代算法,使用这种显式粘滞迭代算法,在较弱条件下,在Hilbert空间中建立了非扩张半群公共不动点集与具有α-可逆g-强单调映象的广义变分不等式解集的公共元素的强收敛定理,推广和改进了相关结果.     

WO3 nanoflakes decorated with CuO clusters for enhanced photoelectrochemical water splitting

The low quantum efficiency arising from poor charges transfer and insufficient light absorption is one of the critical challenges toward achieving highly efficient water splitting in photoelectrochemical cells. Three dimensions(3D) structures and heterojunctions have received intensive research interests recent years due to their excellent ability to separate photo-generated charges as well as the enhanced light harvesting property. Herein,3 D Cu O/WO_3 structure was fabricated through a facile solvothermal method followed by chemical bath deposition. The loading of Cu O clusters on WO_3 nanoflake arrays results in a much improved photocurrent density compared with that of pristine WO_3 nanoflake arrays, which reaches 1.8 m A/cm2 at 1.23 V vs. the reversible hydrogen electrode. The electrochemical impedance spectroscopy measurement demonstrates that the improved performance of Cu O/WO_3 electrode is attributed to the accelerated charge transfer kinetics as a result of the desirable band alignment in Cu O/WO_3 heterojunction. This work demonstrates a facile strategy to construct superior WO_3 electrode, which will ultimately allow for efficient storage of solar energy into hydrogen.     

Recovery of learning and memory is associated with chromatin remodelling

Neurodegenerative diseases of the central nervous system are often associated with impaired learning and memory, eventually leading to dementia. An important aspect in pre-clinical research is the exploration of strategies to re-establish learning ability and access to long-term memories. By using a mouse model that allows temporally and spatially restricted induction of neuronal loss, we show here that environmental enrichment reinstated learning behaviour and re-established access to long-term memories after significant brain atrophy and neuronal loss had already occurred. Environmental enrichment correlated with chromatin modifications (increased histone-tail acetylation). Moreover, increased histone acetylation by inhibitors of histone deacetylases induced sprouting of dendrites, an increased number of synapses, and reinstated learning behaviour and access to long-term memories. These data suggest that inhibition of histone deacetylases might be a suitable therapeutic avenue for neurodegenerative diseases associated with learning and memory impairment, and raises the possibility of recovery of long-term memories in patients with dementia.     

盐酸坦洛新缓释滴丸的处方工艺研究

研究了盐酸坦洛新(TSLS)缓释滴丸的处方工艺.采用聚乙二醇6000和聚乙二醇4000为速释性固体分散载体材料,硬脂酸及单硬脂酸甘油酯为缓释性骨架材料,熔融法制备缓释滴丸.以滴丸圆整度和丸重的RSD为指标,对TSLS缓释滴丸的制备工艺进行了优化.所得滴丸的圆整度好、丸重差异小,体外释放符合Higuchi模型,可持续释药24 h.