Did Nile flooding sink two ancient cities?

The discovery of the two cities of Herakleion and East Canopus under the waters of the Bay of Abu Qir (east of Alexandria, Egypt) stirred worldwide attention when it was first announced in the summer of 2000. Their disappearance some 1,250 years ago has been ascribed by Stanley, Goddio and Schnepp to a strong Nile flood that caused riverbank failure and the destruction of the two cities, rather than to the action of earthquakes, as was first proposed when the ruins were discovered. But I believe that this interpretation is flawed, because no flood could have reached the Abu Qir Bay at the time of the disappearance of the two cities, as the Canopic branch of the Nile, along whose banks they were situated, had dried to a trickle more than 200 years earlier.     

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

Cysteinyl leukotrienes are key mediators in inflammation and have an important role in acute and chronic inflammatory diseases of the cardiovascular and respiratory systems, in particular bronchial asthma. In the biosynthesis of cysteinyl leukotrienes, conversion of arachidonic acid forms the unstable epoxide leukotriene A4 (LTA4). This intermediate is conjugated with glutathione (GSH) to produce leukotriene C4 (LTC4) in a reaction catalysed by LTC4 synthase: this reaction is the key step in cysteinyl leukotriene formation. Here we present the crystal structure of the human LTC4 synthase in its apo and GSH-complexed forms to 2.00 and 2.15 A resolution, respectively. The structure reveals a homotrimer, where each monomer is composed of four transmembrane segments. The structure of the enzyme in complex with substrate reveals that the active site enforces a horseshoe-shaped conformation on GSH, and effectively positions the thiol group for activation by a nearby arginine at the membrane-enzyme interface. In addition, the structure provides a model for how the omega-end of the lipophilic co-substrate is pinned at one end of a hydrophobic cleft, providing a molecular 'ruler' to align the reactive epoxide at the thiol of glutathione. This provides new structural insights into the mechanism of LTC4 formation, and also suggests that the observed binding and activation of GSH might be common for a family of homologous proteins important for inflammatory and detoxification responses.     

Models, scientific realism, the intelligibility of nature, and their cultural significance

In this article, I will view realist and non-realist accounts of scientific models within the larger context of the cultural significance of scientific knowledge. I begin by looking at the historical context and origins of the problem of scientific realism, and claim that it is originally of cultural and not only philosophical, significance. The cultural significance of debates on the epistemological status of scientific models is then related to the question of ‘intelligibility’ and how science, through models, can give us knowledge of the world by presenting us with an ‘intelligible account/picture of the world’, thus fulfilling its cultural-epistemic role. Realists typically assert that science can perform this role, while non-realists deny this. The various strategies adopted by realists and non-realists in making good their respective claims, is then traced to their cultural motivations. Finally I discuss the cultural implications of adopting realist or non-realist views of models through a discussion of the views of Rorty, Gellner, Van Fraassen and Clifford Hooker on the cultural significance of scientific knowledge.     

Genome sequencing in microfabricated high-density picolitre reactors

The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments. The apparatus uses a novel fibre-optic slide of individual wells and is able to sequence 25 million bases, at 99% or better accuracy, in one four-hour run. To achieve an approximately 100-fold increase in throughput over current Sanger sequencing technology, we have developed an emulsion method for DNA amplification and an instrument for sequencing by synthesis using a pyrosequencing protocol optimized for solid support and picolitre-scale volumes. Here we show the utility, throughput, accuracy and robustness of this system by shotgun sequencing and de novo assembly of the Mycoplasma genitalium genome with 96% coverage at 99.96% accuracy in one run of the machine.     

Effect of reduction roasting by using bio-char derived from empty fruit bunch on the magnetic properties of Malaysian iron ore

Beneficiation of Malaysian iron ore is becoming necessary as iron resources are depleting. However, the upgrading process is challenging because of the weak magnetic properties of Malaysian iron ore. In this study, bio-char derived from oil palm empty fruit bunch (EFB) was utilized as an energy source for reduction roasting. Mixtures of Malaysian iron ore and the bio-char were pressed into briquettes and subjected to reduction roasting processes at 873–1173 K. The extent of reduction was estimated on the basis of mass loss, and the magnetization of samples was measured using a vibrating sample magnetometer (VSM). When reduced at 873 K, the original goethite-rich ore was converted into hematite. An increase in temperature to 1073 K caused a significant conversion of hematite into magnetite and enhanced the magnetic susceptibility and saturation magnetization of samples. The magnetic properties diminished at 1173 K as the iron ore was partially reduced to wustite. This reduction roasting by using the bio-char can assist in upgrading the iron ore by improving its magnetic properties.     

Effect of deep cryogenic treatment on the properties of 80CrMo12 5 tool steel

The effect of deep cryogenic treatment on the mechanical properties of 80CrMo12 5 tool steel was investigated. Moreover, the effects of stabilization (holding at room temperature for some periods before deep cryogenic treatment) and tempering before deep cryogenic treatment were studied. The results show that deep cryogenic treatment can eliminate the retained austenite, making a better carbide distribution and a higher carbide amount. As a result, a remarkable improvement in wear resistance of cryogenically treated specimens is observed. Moreover, the ultimate tensile strength increases, and the toughness of the sample decreases. It is also found that both stabilization and tempering before deep cryogenic treatment decrease the wear resistance, hardness, and carbides homogeneity compared to the deep cryogenically treated samples. It is concluded that deep cryogenic treatment should be performed without any delay on samples after quenching to reach the highest wear resistance and hardness.     

How New Individuals Behave in a Heterogeneous Community: A Computational Approach to Norm Assimilation Using Agent-Based Systems

Heterogeneous community entails a number of social groups that adopt similar/different social norms. In such community, new individuals who join a new social group should be able to decide with which group they could assimilate based on their capabilities/values/manners. Otherwise, they would be penalized by other members in the group for violating some norms which they cannot comply.Using this approach, software agents would have better reasoning in simulating human society. In this paper, the authors propose a norms assimilation theory, in which a new agent attempts to assimilate with a social group's norms. This theory builds an approach to norm assimilation, analyzes the cases for an agent to decide to assimilate with a social group and develops a mathematical model to measure the assimilation cost and the agent's ability. The approach is developed based on the agent's internal belief about its ability and desire, and its external belief about the cost of assimilating with a number of social groups. The significance of this research is two-fold. Firstly, the study paves the way to future design of intelligent systems, i.e., software agents or robots, to closely mimic human social interactions.Secondly, the norm assimilation using agent-based system could be potentially utilized to simulate some social issues such as immigrants, new students, expatriate etc. The experiments that have been conducted demonstrate that an agent in the domain is able to calculate the assimilation cost and decide which social group to join.     

满足换位子条件环的交换性(英文)

本文证明:有1环R是交换的充要条件是有正整数m,q,使对每个y∈R有正整数n(y)对一切x∈R有或。     

Monitoring of Policy Implementation: Convergent Mobile and Fixed Technologies as Emergent Enablers

Based on the viable system model (VSM), a system viability refers to the capability of a system to exist and maintain its sustainability within an environment. In this framework, monitoring function supports the gathering of relevant information directly from the operating units and feeding them into the formal control function. In turn, the control function uses the information to produce reports for the higher level functions of intelligence and policymaking, which later utilise these information for their decision making. Given its role, monitoring function supports the viability of a system, especially in large-scale policy-based system. However, studies on the functions of a system monitoring are generally lacking, leading to the lack of understanding on how to conduct monitoring in a viable system implementation. The objectives of this study are a) to discuss the role of monitoring in a viable system framework, and b) to conceptualize the function of monitoring within a policy-based system that is enabled by technologies. To achieve these objectives, this study reviews the literature on monitoring (in relation to VSM framework), on research process in general, as well as on technology adoption. This conceptual exploration generates an emergent viable system model that can guide future researchers in conducting an action research of monitoring function implementation.     

Diagnosing Business Incubation for Social Purpose: A Viable System Model Approach

Systemic Practice and Action Research - Business incubation is one of the means that promotes the overall business and economic growth of a particular location. However, to date, the role of...