排序方式: 共有5条查询结果,搜索用时 78 毫秒
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Kalscheuer VM Freude K Musante L Jensen LR Yntema HG Gécz J Sefiani A Hoffmann K Moser B Haas S Gurok U Haesler S Aranda B Nshedjan A Tzschach A Hartmann N Roloff TC Shoichet S Hagens O Tao J Van Bokhoven H Turner G Chelly J Moraine C Fryns JP Nuber U Hoeltzenbein M Scharff C Scherthan H Lenzner S Hamel BC Schweiger S Ropers HH 《Nature genetics》2003,35(4):313-315
We found mutations in the gene PQBP1 in 5 of 29 families with nonsyndromic (MRX) and syndromic (MRXS) forms of X-linked mental retardation (XLMR). Clinical features in affected males include mental retardation, microcephaly, short stature, spastic paraplegia and midline defects. PQBP1 has previously been implicated in the pathogenesis of polyglutamine expansion diseases. Our findings link this gene to XLMR and shed more light on the pathogenesis of this common disorder. 相似文献
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Ahmed ZM Masmoudi S Kalay E Belyantseva IA Mosrati MA Collin RW Riazuddin S Hmani-Aifa M Venselaar H Kawar MN Tlili A van der Zwaag B Khan SY Ayadi L Riazuddin SA Morell RJ Griffith AJ Charfedine I Caylan R Oostrik J Karaguzel A Ghorbel A Riazuddin S Friedman TB Ayadi H Kremer H 《Nature genetics》2008,40(11):1335-1340
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COURSE TIMETABLING AT A TUNISIAN UNIVERSITY: A CASE STUDY 总被引:2,自引:0,他引:2
Abdelaziz DAMMAK Abdelkarim ELLOUMI Hichem KAMOUN Jacques A.FERLAND 《系统科学与系统工程学报(英文版)》2008,17(3):334-352
This paper deals with the Course Timetabling Problem at an institution in a Tunisian University. We introduce a heuristic procedure to construct a feasible timetable for all lectures and tutorials taken by different groups of each sub-section of any section. We describe the timetabling problem using a list of all specific hard and soft constraints. We formulate the problem as a set of linear constraints using two sets of binary variables corresponding to lectures and tutorials, respectively. This heuristic is illustrated with real data for a sub-section of the Faculty of Economics and Management Sciences of Sfax in Tunisia, and the resulting timetables are compared with those generated manually. The results of another full section have confirmed the good quality of the proposed heuristic when compared with the hand made solution. 相似文献
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Systemic Practice and Action Research - This paper proposes a new theory called the Viable System Ontology Theory, which is an interrelation among two well-known theories in social science. The... 相似文献
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