全文获取类型
收费全文 | 231篇 |
免费 | 0篇 |
国内免费 | 1篇 |
专业分类
丛书文集 | 1篇 |
现状及发展 | 77篇 |
研究方法 | 29篇 |
综合类 | 114篇 |
自然研究 | 11篇 |
出版年
2018年 | 4篇 |
2017年 | 2篇 |
2016年 | 3篇 |
2015年 | 1篇 |
2013年 | 1篇 |
2012年 | 13篇 |
2011年 | 31篇 |
2010年 | 6篇 |
2009年 | 2篇 |
2008年 | 7篇 |
2007年 | 6篇 |
2006年 | 10篇 |
2005年 | 7篇 |
2004年 | 17篇 |
2003年 | 6篇 |
2002年 | 6篇 |
2001年 | 6篇 |
2000年 | 5篇 |
1999年 | 7篇 |
1996年 | 1篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1979年 | 7篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1975年 | 6篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1972年 | 4篇 |
1971年 | 3篇 |
1970年 | 7篇 |
1969年 | 4篇 |
1968年 | 3篇 |
1966年 | 1篇 |
1965年 | 1篇 |
1964年 | 2篇 |
1959年 | 2篇 |
1955年 | 1篇 |
排序方式: 共有232条查询结果,搜索用时 46 毫秒
1.
2.
E. Flückiger U. Briner B. Clark A. Closse A. Enz P. Gull A. Hofmann R. Markstein L. Tolcsvai H. R. Wagner 《Cellular and molecular life sciences : CMLS》1988,44(5):431-436
Summary The profile of action in animals of CQP 201-403, a novel 8-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel®).In memory of Dr Annemarie Closse, who died 14 June 1987. 相似文献
3.
4.
Cryptic variation is caused by the robustness of phenotypes to mutations. Cryptic variation has no effect on phenotypes in a given genetic or environmental background, but it can have effects after mutations or environmental change. Because evolutionary adaptation by natural selection requires phenotypic variation, phenotypically revealed cryptic genetic variation may facilitate evolutionary adaptation. This is possible if the cryptic variation happens to be pre-adapted, or "exapted", to a new environment, and is thus advantageous once revealed. However, this facilitating role for cryptic variation has not been proven, partly because most pertinent work focuses on complex phenotypes of whole organisms whose genetic basis is incompletely understood. Here we show that populations of RNA enzymes with accumulated cryptic variation adapt more rapidly to a new substrate than a population without cryptic variation. A detailed analysis of our evolving RNA populations in genotype space shows that cryptic variation allows a population to explore new genotypes that become adaptive only in a new environment. Our observations show that cryptic variation contains new genotypes pre-adapted to a changed environment. Our results highlight the positive role that robustness and epistasis can have in adaptive evolution. 相似文献
5.
Understanding exotic forms of magnetism in quantum mechanical systems is a central goal of modern condensed matter physics, with implications for systems ranging from high-temperature superconductors to spintronic devices. Simulating magnetic materials in the vicinity of a quantum phase transition is computationally intractable on classical computers, owing to the extreme complexity arising from quantum entanglement between the constituent magnetic spins. Here we use a degenerate Bose gas of rubidium atoms confined in an optical lattice to simulate a chain of interacting quantum Ising spins as they undergo a phase transition. Strong spin interactions are achieved through a site-occupation to pseudo-spin mapping. As we vary a magnetic field, quantum fluctuations drive a phase transition from a paramagnetic phase into an antiferromagnetic phase. In the paramagnetic phase, the interaction between the spins is overwhelmed by the applied field, which aligns the spins. In the antiferromagnetic phase, the interaction dominates and produces staggered magnetic ordering. Magnetic domain formation is observed through both in situ site-resolved imaging and noise correlation measurements. By demonstrating a route to quantum magnetism in an optical lattice, this work should facilitate further investigations of magnetic models using ultracold atoms, thereby improving our understanding of real magnetic materials. 相似文献
6.
Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing 总被引:1,自引:0,他引:1
Reuter M Berninger P Chuma S Shah H Hosokawa M Funaya C Antony C Sachidanandam R Pillai RS 《Nature》2011,480(7376):264-267
7.
8.
Morelli G Song Y Mazzoni CJ Eppinger M Roumagnac P Wagner DM Feldkamp M Kusecek B Vogler AJ Li Y Cui Y Thomson NR Jombart T Leblois R Lichtner P Rahalison L Petersen JM Balloux F Keim P Wirth T Ravel J Yang R Carniel E Achtman M 《Nature genetics》2010,42(12):1140-1143
Plague is a pandemic human invasive disease caused by the bacterial agent Yersinia pestis. We here report a comparison of 17 whole genomes of Y. pestis isolates from global sources. We also screened a global collection of 286 Y. pestis isolates for 933 SNPs using Sequenom MassArray SNP typing. We conducted phylogenetic analyses on this sequence variation dataset, assigned isolates to populations based on maximum parsimony and, from these results, made inferences regarding historical transmission routes. Our phylogenetic analysis suggests that Y. pestis evolved in or near China and spread through multiple radiations to Europe, South America, Africa and Southeast Asia, leading to country-specific lineages that can be traced by lineage-specific SNPs. All 626 current isolates from the United States reflect one radiation, and 82 isolates from Madagascar represent a second radiation. Subsequent local microevolution of Y. pestis is marked by sequential, geographically specific SNPs. 相似文献
9.
We examined optimal temperatures for growth and the upper thermal tolerance of juvenile northern leatherside chub ( Lepidomeda copei ). We conducted 2 experiments using the acclimated chronic-exposure method to estimate optimal temperature for growth of age-0 northern leatherside chub (range 12.8–28.3 °C). Upper thermal tolerance was estimated using the critical thermal maximum (CTM) and upper incipient lethal temperature (UILT) methods for fish acclimated at 15, 18, 23, and 28 °C. We also measured stream temperatures in Yellow Creek, Summit County, Utah, during July–August 2006 to compare our results to actual summer stream temperatures. Survival in growth tests was not significantly different between treatment temperatures in either experiment (P > 0.098). The optimal temperature for growth in the 1st trial estimated from the 2nd-order polynomial regression was 23.0 °C, falling outside the range of experimental temperatures (12.8–22.2 °C). The estimated optimal temperature for growth in the 2nd trial was 23.2 °C. In the upper thermal tolerance tests, juvenile northern leatherside chub had CTM values between 29.6 and 35.0 °C; CTM values increased as acclimation temperature increased. Upper incipient lethal temperatures (LT50) ranged from 26.5 to 30.2 °C, increasing with acclimation temperature. Summer stream temperatures in Yellow Creek had a lower mean (14.0–18.1 °C) than did the optimal temperature for growth determined in these studies, but these temperatures exhibited diel fluctuations as large as 15.7 °C. 相似文献
10.
Numerous potentially functional but non-genic conserved sequences on human chromosome 21 总被引:28,自引:0,他引:28
Dermitzakis ET Reymond A Lyle R Scamuffa N Ucla C Deutsch S Stevenson BJ Flegel V Bucher P Jongeneel CV Antonarakis SE 《Nature》2002,420(6915):578-582
The use of comparative genomics to infer genome function relies on the understanding of how different components of the genome change over evolutionary time. The aim of such comparative analysis is to identify conserved, functionally transcribed sequences such as protein-coding genes and non-coding RNA genes, and other functional sequences such as regulatory regions, as well as other genomic features. Here, we have compared the entire human chromosome 21 with syntenic regions of the mouse genome, and have identified a large number of conserved blocks of unknown function. Although previous studies have made similar observations, it is unknown whether these conserved sequences are genes or not. Here we present an extensive experimental and computational analysis of human chromosome 21 in an effort to assign function to sequences conserved between human chromosome 21 (ref. 8) and the syntenic mouse regions. Our data support the presence of a large number of potentially functional non-genic sequences, probably regulatory and structural. The integration of the properties of the conserved components of human chromosome 21 to the rapidly accumulating functional data for this chromosome will improve considerably our understanding of the role of sequence conservation in mammalian genomes. 相似文献