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Neurodegenerative diseases of the central nervous system are often associated with impaired learning and memory, eventually leading to dementia. An important aspect in pre-clinical research is the exploration of strategies to re-establish learning ability and access to long-term memories. By using a mouse model that allows temporally and spatially restricted induction of neuronal loss, we show here that environmental enrichment reinstated learning behaviour and re-established access to long-term memories after significant brain atrophy and neuronal loss had already occurred. Environmental enrichment correlated with chromatin modifications (increased histone-tail acetylation). Moreover, increased histone acetylation by inhibitors of histone deacetylases induced sprouting of dendrites, an increased number of synapses, and reinstated learning behaviour and access to long-term memories. These data suggest that inhibition of histone deacetylases might be a suitable therapeutic avenue for neurodegenerative diseases associated with learning and memory impairment, and raises the possibility of recovery of long-term memories in patients with dementia. 相似文献
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Two new species of mites of the genus Premicrodispus Cross, 1965 (Acari: Microdispidae) are described and illustrated from northern Iran: Premicrodispus paramaevi Hosseininaveh and Hajiqanbar sp. nov. recovered from Lucanus ibericus (Col.: Lucanidae) and Premicrodispus spinosus Hosseininaveh and Hajiqanbar sp. nov. from Corticeus unicolor (Col.: Tenebrionidae). It is the first phoretic record of the microdispid mites on beetles of the family Tenebrionidae. A key to Palaearctic species of the genus Premicrodispus is provided.http://zoobank.org/urn:lsid:zoobank.org:pub:49368637-B8D0-4697-9184-28B33B89962A 相似文献
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