抗氧化类辐射防护剂的研究进展

抗氧化类辐射防护剂是通过与辐射产生的自由基反应,阻断重要生物分子由于辐射损伤引起的连锁反应,从根本上发挥抗辐射作用。对茶多酚、黄酮类、多糖等抗氧化类辐射防护剂的特性、抗辐射效果、作用机制进行了综述,并展望其研究前景。     

了解midi 不再雾里看花!

MIDI IN 接收其他设备发送过来的信息MIDI OUT:向其他设备发送信息MIDI THRU:通过这个口把两个相隔的 midi 设备相连,并把接受来的 midi 信息发送出去其中最容易使人混淆的就是“THRU”了,因为有的设备已经把 MIDI OUT 与 THRU 合并为同一个插口。这说明,首先,THRU 同 OUT 有相同的功能,就是向外发送信息。但是这两者不相同的是,OUT 只是向其他设备发送来自于设备本身的 midi     

Transthyretin binds to glucose-regulated proteins and is subjected to endocytosis by the pancreatic β-cell

Transthyretin (TTR) is a functional protein in the pancreatic β-cell. It promotes insulin release and protects against β-cell death. We now demonstrate by ligand blotting, adsorption to specific magnetic beads, and surface plasmon resonance that TTR binds to glucose-regulated proteins (Grps)78, 94, and 170, which are members of the endoplasmic reticulum chaperone family, but Grps78 and 94 have also been found at the plasma membrane. The effect of TTR on changes in cytoplasmic free Ca²⁺ concentration ([Ca²⁺]_i) was abolished if the cells were treated with either dynasore, a specific inhibitor of dynamin GTPase that blocks clathrin-mediated endocytosis, or an antibody against Grp78, that prevents TTR from binding to Grp78. The conclusion is that TTR binds to Grp78 at the plasma membrane, is internalized into the β-cell via a clathrin-dependent pathway, and that this internalization is necessary for the effects of TTR on β-cell function.