Summ
ary 2 new limonoid-type terpenes h
ave been isol
ated from
an
aqueous extr
act of seeds produced by the E
astern Him
al
ay
an (Indi
a) pl
ant
Aphanamixis grandifolia Bl. By interpreting princip
ally m
ass spectr
al
and nucle
ar m
agnetic reson
ance d
at
a, the structures of 12-hydroxy
amoor
ast
atin (
2b)
and
amoor
ast
atone (
3) were elucid
ated. Unequivoc
al evidence for the 12-hydroxy
amoor
ast
atin structur
al
assignment w
as obt
ained by chemic
al conversion to send
anin (
4). Amoor
ast
atin deriv
ative
2b w
as found to signific
antly inhibit growth of the murine P388 lymphocytic leukemi
a cell lines but
amoor
ast
atone in the s
ame system w
as in
active. In
a comp
ar
ative biologic
al study, send
anin (
4)
and
anthothecol (
7) were
also found signific
antly to inhibit growth of the P388 cell line, while rohitukin (
8)
and limonin (
9) were found to be in
active.P
art 63 of the series arge8216.gif"
alt="lsquo"
align="BASELINE" BORDER="0">Antineopl
astic Agentsarge8217.gif"
alt="rsquo"
align="BASELINE" BORDER="0">. For the previous contribution refer to G.R. Pettit, T.S. Krup
a and R.M. Reynolds, Int. J. Peptide Protein Res., in prep
ar
ation. The present investig
ation w
as supported in p
art by Public He
alth Rese
arch Gr
ant No. CA-16049-05 from the N
ation
al C
ancer Institute, the F
annie E. Rippel Found
ation, Mrs M
ary Dell Pritzl
aff, the Spencer T.
and Ann W. Olin Found
ation, Mr John F. Schmidt,
and the Phoenix Coc
a-Col
a Bottling Comp
any.
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