Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.     

一类非线性系统的稳定性

研究了一类非线性系统的输入输出稳定性问题，这类系统的特点是其模型为系统输出的线性拟函数。对非线性稳定性系统，利用稳定性的线性等价原理，提出了这一类非线性系统的稳定性判据；对非线性随机系统，给出了m阶均值意义下的稳定性定义，提出了一种二阶均值下的输入输出稳定性条件，给出了几个示例说明。