排序方式: 共有36条查询结果,搜索用时 15 毫秒
1.
Yue Shi Guang Yang Jia Yu Lina Yu Ruth Westenbroek William A. Catterall Lisa Juntti-Berggren Per-Olof Berggren Shao-Nian Yang 《Cellular and molecular life sciences : CMLS》2014,71(7):1289-1303
Apolipoprotein CIII (ApoCIII) not only serves as an inhibitor of triglyceride hydrolysis but also participates in diabetes-related pathological events such as hyperactivation of voltage-gated Ca2+ (CaV) channels in the pancreatic β cell. However, nothing is known about the molecular mechanisms whereby ApoCIII hyperactivates β cell CaV channels. We now demonstrate that ApoCIII increased CaV1 channel open probability and density. ApoCIII enhanced whole-cell Ca2+ currents and the CaV1 channel blocker nimodipine completely abrogated this enhancement. The effect of ApoCIII was not influenced by individual inhibition of PKA, PKC, or Src. However, combined inhibition of PKA, PKC, and Src counteracted the effect of ApoCIII, similar results obtained by coinhibition of PKA and Src. Moreover, knockdown of β1 integrin or scavenger receptor class B type I (SR-BI) prevented ApoCIII from hyperactivating β cell CaV channels. These data reveal that ApoCIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src. 相似文献
2.
通过正交实验研究,测试了铸造涂料的碾压工艺、原材料以及原材料的处理工艺对涂料的悬浮性、表面强度、发气量等主要工艺性能的影响。结果表明:当选用轮碾机制作铸造涂料时,碾压时间达到1.5小时即可满足工艺性能的要求;涂料中无论是粘结剂还是悬浮剂的增加均会大幅度提高涂料的表面强度和悬浮性。 相似文献
3.
薛云灿 《河海大学常州分校学报》2000,14(3):26-30
通过分析了CMAC神经网络的学习机制和连续搅拌反应釜的结构,提出了一种自动选择学习率的CMAC自学习控制方法。给出了自学习控制器的结构和算法,并以连续搅拌反应釜模型为对象进行了仿真研究,这种网络每次学习少量参数,算法简单,仿真结果表明所提出的控制器优于传统的PID控制器。 相似文献
4.
介绍了利用图象处理技术研究了Sn-Pb合金钱民铜润湿性的方法,提出了联机的图象特征提出算法和润湿参数求取算法,给出了Sn-Pb/Cu润湿特性在直流电影响下测试分析结果。 相似文献
5.
D Vilchez L Boyer I Morantte M Lutz C Merkwirth D Joyce B Spencer L Page E Masliah WT Berggren FH Gage A Dillin 《Nature》2012,489(7415):304-308
6.
针对易混淆词特征差异小,分类决策困难的特点,提出了一种新的语音识别特征。该特征可以根据待识单词的发音特点,通过选用合适的基函数及加权处理,突出混淆词特征之间的差异性; 相似文献
7.
我国淡水水产品加工业的现状与前景展望 总被引:13,自引:0,他引:13
通过分析我国水产品养殖业和加工业的现状、存在问题以及人们将来对淡水水产品深精加工食品的需求趋势,指出我国应该大力发展淡水鱼的深精加工技术,生产淡水鱼深精加工方便食品,以满足人们对营养、方便、卫生食品的需求。 相似文献
8.
J. L. Berggren 《Archive for History of Exact Sciences》1991,43(2):133-144
Communicated by A. Aaboe 相似文献
9.
C Amm?l? O Larsson P O Berggren K Bokvist L Juntti-Berggren H Kindmark P Rorsman 《Nature》1991,353(6347):849-852
Glucose-stimulated insulin secretion is associated with the appearance of electrical activity in the pancreatic beta-cell. At intermediate glucose concentrations, beta-cell electrical activity follows a characteristic pattern of slow oscillations in membrane potential on which bursts of action potentials are superimposed. The electrophysiological background of the bursting pattern remains unestablished. Activation of Ca(2+)-activated large-conductance K+ channels (KCa channel) has been implicated in this process but seems unlikely in view of recent evidence demonstrating that the beta-cell electrical activity is unaffected by the specific KCa channel blocker charybdotoxin. Another hypothesis postulates that the bursting arises as a consequence of two components of Ca(2+)-current inactivation. Here we show that activation of a novel Ca(2+)-dependent K+ current in glucose-stimulated beta-cells produces a transient membrane repolarization. This interrupts action potential firing so that action potentials appear in bursts. Spontaneous activity of this current was seen only rarely but could be induced by addition of compounds functionally related to hormones and neurotransmitters present in the intact pancreatic islet. K+ currents of the same type could be evoked by intracellular application of GTP, the effect of which was mediated by mobilization of Ca2+ from inositol 1,4,5-trisphosphate (InsP3)-sensitive intracellular Ca2+ stores. These observations suggest that oscillatory glucose-stimulated electrical activity, which is correlated with pulsatile release of insulin, results from the interaction between the beta-cell and intraislet hormones and neurotransmitters. Our data also provide evidence for a close interplay between ion channels in the plasma membrane and InsP3-induced mobilization of intracellular Ca2+ in an excitable cell. 相似文献
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