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LEE Eun-Ok LEE Hyo-Jung LEE Hyo-Jeong KIM Kwan-Hyun WON Sook-Hyun LEE Jae-Dong AHN Kwang Seok AHN Kyoo Seok KIM Jung-Hyo YU Young-Beob KIM Sung-Hoon 《科学通报(英文版)》2009,54(2):227-233
Oriental herbal medicines have been widely used for the prevention or treatment of various diseases including cancer in Asia.
However, to prove their chemo preventive efficacies in modern times, scientific evidence for those herbal medicines is required.
Thus, in the present study, an effective herbal cocktail Bojungbangdocktang (BJBDT) was investigated to elucidate antiangiogenic
mechanism in vitro and in vivo. BJBDT significantly inhibited vascular endothelial growth factor (VEGF) induced proliferation in HUVECs at nontoxic concentrations,
despite weak cytotoxicity against human umbilical vein endothelial cells (HUVECs). BJBDT also significantly suppressed VEGF-induced
migration and tube formation of HUVECs. Furthermore, BJBDT treatment resulted in pale color and low hemoglobin level in Matrigel
plugs, as well as dark red color and high hemoglobin level in untreated control. Interestingly, BJBDT specifically inhibited
the binding of VEGF to vascular endothelial growth factor receptor 2 (VEGFR2), but not VEGFR1. In addition, friedelin, formononetin,
ginsenoside Rb1, naringin, atractyloside, diosgenin, and allantonin were identified from BJBDT by high-performance liquid
chromatography (HPLC) analysis as a quality of control. Taken together, these results suggest that BJBDT is a potent angiogenesis
inhibitor blocking the VEGF/VEGFR2 signaling pathway in HUVECs.
Supported by the Korea Science and Engineering Foundation Grant from the Korean Government (Ministry of Science and Technology)
(Grant No. R13-2007-019-00000-0) 相似文献
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