排序方式: 共有28条查询结果,搜索用时 15 毫秒
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Burdon KP Macgregor S Hewitt AW Sharma S Chidlow G Mills RA Danoy P Casson R Viswanathan AC Liu JZ Landers J Henders AK Wood J Souzeau E Crawford A Leo P Wang JJ Rochtchina E Nyholt DR Martin NG Montgomery GW Mitchell P Brown MA Mackey DA Craig JE 《Nature genetics》2011,43(6):574-578
We report a genome-wide association study for open-angle glaucoma (OAG) blindness using a discovery cohort of 590 individuals with severe visual field loss (cases) and 3,956 controls. We identified associated loci at TMCO1 (rs4656461[G] odds ratio (OR) = 1.68, P = 6.1 × 10(-10)) and CDKN2B-AS1 (rs4977756[A] OR = 1.50, P = 4.7 × 10(-9)). We replicated these associations in an independent cohort of cases with advanced OAG (rs4656461 P = 0.010; rs4977756 P = 0.042) and two additional cohorts of less severe OAG (rs4656461 combined discovery and replication P = 6.00 × 10(-14), OR = 1.51, 95% CI 1.35-1.68; rs4977756 combined P = 1.35 × 10(-14), OR = 1.39, 95% CI 1.28-1.51). We show retinal expression of genes at both loci in human ocular tissues. We also show that CDKN2A and CDKN2B are upregulated in the retina of a rat model of glaucoma. 相似文献
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N Viswanathan 《Experientia》1989,45(4):383-385
The relative roles of conflicting zeitgebers [presence/absence (PA) cycles versus light/dark (LD) cycles] on entrainment of circadian rhythm of locomotor activity were tested in pups of the night active mouse Mus booduga. During the early days of the pups' life the PA cycles of the mother acted as a zeitgeber and entrained their activity rhythm, even though the LD cycles were available. Entrainment by LD cycles took place only when the pups' eyes opened and probably became functional. 相似文献
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N. Narasimhachari B. N. Vasavada S. Viswanathan 《Cellular and molecular life sciences : CMLS》1965,21(7):376-376
Zusammenfassung Aus Herqueinon erhält man Desoxyherqueinon (Atrovenetin-monomethyl-äther) mit antibakteriellen Eigenschaften. Spektrum ähnlich wie Atrovenetin, obwohl die minimale Hemmungskonzentration höher liegt. 相似文献
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I. N. Bhatt T. A. Venkitasubramaniam R. Viswanathan 《Cellular and molecular life sciences : CMLS》1960,16(12):537
Zusammenfassung Der Einfluss einer Ganzkörperbestrahlung mit CO60--Strahlen auf die Blutlipoide von Ratten wurde untersucht. Die Gesamtblutlipoide waren 24 h nach der Bestrahlung um 38,8% erhöht. Die Cholesterin- und Phospholipoidkonzentration des Bluts blieb unverändert.
Our thanks are due to the Indian Council of Medical Research for financial aid and to Dr.Brewbaker, U.S. Atomic Energy Pavilion, World Agriculture Fair, New Delhi, 1960 for irradiation facilities. 相似文献
Our thanks are due to the Indian Council of Medical Research for financial aid and to Dr.Brewbaker, U.S. Atomic Energy Pavilion, World Agriculture Fair, New Delhi, 1960 for irradiation facilities. 相似文献
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N. Viswanathan M. K. Chandrashekaran 《Cellular and molecular life sciences : CMLS》1987,43(5):576-578
Summary 1212-h cycles of presence and absence of mother mouse act as a zeitgeber and entrain the circadian rhythm of locomotor activity in the pups ofMus booduga under continuous darkness or continuous dim light. Continuous higher illumination of 15–25 lx abolishes this impressive maternal entrainment.Acknowledgment. We are grateful to the DST, Government of India, for financial support under their IRHPA scheme. N.V. is the recipient of a Senior Research Fellowship of CSIR, New Delhi. We thank Dr. R. Subbaraj for discussions. 相似文献
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Optimizing the success of random searches. 总被引:3,自引:0,他引:3
G M Viswanathan S V Buldyrev S Havlin M G da Luz E P Raposo H E Stanley 《Nature》1999,401(6756):911-914
We address the general question of what is the best statistical strategy to adapt in order to search efficiently for randomly located objects ('target sites'). It is often assumed in foraging theory that the flight lengths of a forager have a characteristic scale: from this assumption gaussian, Rayleigh and other classical distributions with well-defined variances have arisen. However, such theories cannot explain the long-tailed power-law distributions of flight lengths or flight times that are observed experimentally. Here we study how the search efficiency depends on the probability distribution of flight lengths taken by a forager that can detect target sites only in its limited vicinity. We show that, when the target sites are sparse and can be visited any number of times, an inverse square power-law distribution of flight lengths, corresponding to Lévy flight motion, is an optimal strategy. We test the theory by analysing experimental foraging data on selected insect, mammal and bird species, and find that they are consistent with the predicted inverse square power-law distributions. 相似文献
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