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于焱 《中国人民公安大学学报(自然科学版)》2002,(5):45-48
随着计算机技术应用的普及和指纹识别技术的日益完善,现行的暂住人口身份证管理系统已逐步呈现出许多缺点和弊端.为解决近年来出现的诸多问题,使用本文提出的指纹IC卡暂住人口身份证管理系统,可以使被查者与本人身份完全一致,能够强化暂住人口的管理. 相似文献
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Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis
Lee YC Kuo HC Chang JS Chang LY Huang LM Chen MR Liang CD Chi H Huang FY Lee ML Huang YC Hwang B Chiu NC Hwang KP Lee PC Chang LC Liu YM Chen YJ Chen CH;Taiwan Pediatric ID Alliance Chen YT Tsai FJ Wu JY 《Nature genetics》2012,44(5):522-525
To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis. 相似文献
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Until recently, the expression and primary function of the cell surface receptor CD40 and its ligand CD154 were considered
restricted to B and T lymphocytes, and their interactions required for the thymus-dependent humoral response. However, current
work from several groups challenges this view of the CD40/CD154 dyad as a mere mediator of lymphocyte communication. A variety
of non-lymphocytic cell types express both receptor and ligand, including hematopoetic and non-hematopoetic cells, such as
monocytes, basophils, eosinophils, dendritic cells, fibroblasts, smooth muscle, and endothelial cells. Accordingly, ligation
of CD40 mediates a broad variety of immune and inflammatory responses, such as the expression of adhesion molecules, cytokines,
matrix-degrading enzymes, prothrombotic activities, and apoptotic mediators. Consequently, CD40 signaling has been associated
with pathogenic processes of chronic inflammatory diseases, such as autoimmune diseases, neurodegenerative disorders, graft-versus-host
disease, cancer, and atherosclerosis. This review focuses on the synthesis and structure of CD40 and outlines CD154/CD40 signaling
pathways, and emphasizes the previously unexpected importance of the CD40/CD154 receptor/ligand dyad in a spectrum of immunoregulatory
processes and prevalent human diseases.
Received 10 January 2000; revised 16 June 2000; accepted 5 July 2000
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ID="†" Review
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ID="*" Corresponding author. 相似文献
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Fünfschilling U Supplie LM Mahad D Boretius S Saab AS Edgar J Brinkmann BG Kassmann CM Tzvetanova ID Möbius W Diaz F Meijer D Suter U Hamprecht B Sereda MW Moraes CT Frahm J Goebbels S Nave KA 《Nature》2012,485(7399):517-521
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term axonal integrity. However, the underlying support mechanisms are not understood. Here we identify a metabolic component of axon-glia interactions by generating conditional Cox10 (protoheme IX farnesyltransferase) mutant mice, in which oligodendrocytes and Schwann cells fail to assemble stable mitochondrial cytochrome c oxidase (COX, also known as mitochondrial complex IV). In the peripheral nervous system, Cox10 conditional mutants exhibit severe neuropathy with dysmyelination, abnormal Remak bundles, muscle atrophy and paralysis. Notably, perturbing mitochondrial respiration did not cause glial cell death. In the adult central nervous system, we found no signs of demyelination, axonal degeneration or secondary inflammation. Unlike cultured oligodendrocytes, which are sensitive to COX inhibitors, post-myelination oligodendrocytes survive well in the absence of COX activity. More importantly, by in vivo magnetic resonance spectroscopy, brain lactate concentrations in mutants were increased compared with controls, but were detectable only in mice exposed to volatile anaesthetics. This indicates that aerobic glycolysis products derived from oligodendrocytes are rapidly metabolized within white matter tracts. Because myelinated axons can use lactate when energy-deprived, our findings suggest a model in which axon-glia metabolic coupling serves a physiological function. 相似文献
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One of the central elements of excitation-contraction coupling, the voltage-sensing dihydropyridine receptor, is believed
to exist as a high-molecular-mass complex in the triad junction. Although freeze-fracture electron microscopical analysis
suggests a tetrad complex, no direct biochemical evidence exists demonstrating the actual size of the native membrane complex.
Using a combination of various two-dimensional gel electrophoresis techniques, we show here that the principal α
1-subunit of the dihydropyridine receptor and its auxiliary α
2-subunit form a triad complex of approximately 2800 kDa under native conditions. Established Ca2+-ATPase tetramers and calsequestrin monomers were employed for the internal standardization of the gel systems used. Thus,
the large voltage-sensing complex appears to be tightly associated, since it does not disintegrate during subcellular fractionation
and native electrophoresis procedures. Our findings support the cell biological hypothesis that native dihydropyridine receptor
units form a tetrad structure within the transverse tubules.
Received 10 October 2000; revised 28 November 2000; accepted 4 January 2001 相似文献
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