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M. Perez-Reyes Martha C. Timmons K. H. Davis E. M. Wall 《Cellular and molecular life sciences : CMLS》1973,29(11):1368-1369
Resumen Se hizo un estudio comparativo de la actividad del
9-tetrahidrocannabinol, cannabinol, y cannabidiol en producir efectos similares a la marihuana cuando son inyectados i.v. a humanos. Estas substancias son los componentes predominantes de la marihuana o del hashish. Se encontro que a las dosis inyectados cannabidiol no tiene ninguna potencia, y que cannabinol es capaz de producir efectos tipicos de la marihuana, aunque a dosis varias veces mas grandes que las del
9-tetrahidrocannabinol. 相似文献
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A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo 总被引:77,自引:0,他引:77
M H Rosner M A Vigano K Ozato P M Timmons F Poirier P W Rigby L M Staudt 《Nature》1990,345(6277):686-692
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M. Rerez-Reyes Martha C. Timmons M. A. Lipton H. D. Christensen K. H. Davis M. E. Wall 《Cellular and molecular life sciences : CMLS》1973,29(8):1009-1010
Resumen Se hizo un estudio comparativo de la capacidad del 9-tetrahidro-cannabinol y de sus metabolitos monohidroxilados en producir effectos similares a los de la marihuana cuando son inyectados intravenosamente a humanos. Se encontro que la hidroxilacion en la posición 11 no cambio la potencia, en la posición 8 la redujo, y en la posición 8 la abolio por completo.
These studies were conducted under Contract No. HSM-42-71-95 between the Center for Studies of Narcotic and Drug Abuse of the Division of Narcotic Addition and Drug Abuse, NIMH, and the Research Triangle Institute. In addition, this investigation was supported by Public Health service Research Grant No. RR-46 from the General Clinical Research Centers Branch of the Division of Research Resources. We thank Drs.Monique Braude and st.Szara, Center for Studies of Narcotic and Drug Abuse, NIMH, for their interest and encouragement of this program. We also thankCarolyn Bishop andDaynise Skeen for their technical assistance. 相似文献
These studies were conducted under Contract No. HSM-42-71-95 between the Center for Studies of Narcotic and Drug Abuse of the Division of Narcotic Addition and Drug Abuse, NIMH, and the Research Triangle Institute. In addition, this investigation was supported by Public Health service Research Grant No. RR-46 from the General Clinical Research Centers Branch of the Division of Research Resources. We thank Drs.Monique Braude and st.Szara, Center for Studies of Narcotic and Drug Abuse, NIMH, for their interest and encouragement of this program. We also thankCarolyn Bishop andDaynise Skeen for their technical assistance. 相似文献
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