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PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes 总被引:30,自引:0,他引:30
Sun Z Arendt CW Ellmeier W Schaeffer EM Sunshine MJ Gandhi L Annes J Petrzilka D Kupfer A Schwartzberg PL Littman DR 《Nature》2000,404(6776):402-407
Productive interaction of a T lymphocyte with an antigen-presenting cell results in the clustering of the T-cell antigen receptor (TCR) and the recruitment of a large signalling complex to the site of cell-cell contact. Subsequent signal transduction resulting in cytokine gene expression requires the activation of one or more of the multiple isoenzymes of serine/threonine-specific protein kinase C (PKC). Among the several PKC isoenzymes expressed in T cells, PKC-theta is unique in being rapidly recruited to the site of TCR clustering. Here we show that PKC-theta is essential for TCR-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. TCR-initiated NF-kappaB activation was absent from PKC-theta(-/-) mature T lymphocytes, but was intact in thymocytes. Activation of NF-kappaB by tumour-necrosis factor alpha and interleukin-1 was unaffected in the mutant mice. Although studies in T-cell lines had suggested that PKC-theta regulates activation of the JNK signalling pathway, induction of JNK was normal in T cells from mutant mice. These results indicate that PKC-theta functions in a unique pathway that links the TCR signalling complex to the activation of NF-kappaB in mature T lymphocytes. 相似文献
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Cellular migration of intestinal epithelia in suckling and weaned rats 总被引:10,自引:0,他引:10
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