萨满医术:北方民族精神医学

治病是北方少数民族萨满的主要职能之一。在信仰萨满教的民族中萨满往往充当民间医生的角色。萨满医术是一种精神医术和心灵医术。萨满主要是治心因性的精神疾病,其主要治疗手段也是一种心理治疗。在萨满医术中包含着现代精神医学中使用的一些治疗方法和治愈机制。萨满的精神医术之本质在于通过各种方式使患者的心理得到平衡,与此同时让患者振作起来,对自己的病情持乐观的态度,确立战胜病魔的信心。萨满精神医术就是一种典型的宗教性心理——生理调控术。对萨满医术,应从心理人类学、医学人类学、宗教人类学等多种角度进行研究,这样才能够得出比较全面而相对正确的结论。     

安哥拉山羊及其杂种羊DNA指纹图谱分析

应用寡苷酸探针(CA/GATA/TCC)     

安哥拉山羊及其杂种羊父权认定的DNA指纹图分析

应用ＤＮＡ指纹技术对安哥拉山羊作亲子鉴定,结果发现子代个体的ＤＮＡ指纹图中,谱带均分别来自父亲和母亲,没有新带出现。父权概率为０．９８８９,表明（ＣＡ／ＧＡＴＡ／ＴＣＣ）５探针能有效地应用于安哥拉山羊及其杂种后代的遗传分析。     

A Kind of Systems Methodology——The SPIPRO Principle

This paper deals with the Self-Increasing-Difficulty system (SIDIS) separated from general systems, with emphasis on the relevant methodology based on the Spiral Combining Propulsion Principle (SPIPRO principle in short). The system feature and its causative factors are analysed, and the implications and mechanism of the SPIPRO principle are discussed. Finally, the application possibilities of this methodology are illustrated with some examples.     

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

Obesity and type-2 diabetes have increased markedly over the past few decades, in parallel. One of the major links between these two disorders is chronic, low-grade inflammation. Prolonged nutrient excess promotes the accumulation and activation of leukocytes in visceral adipose tissue (VAT) and ultimately other tissues, leading to metabolic abnormalities such as insulin resistance, type-2 diabetes and fatty-liver disease. Although invasion of VAT by pro-inflammatory macrophages is considered to be a key event driving adipose-tissue inflammation and insulin resistance, little is known about the roles of other immune system cell types in these processes. A unique population of VAT-resident regulatory T (Treg) cells was recently implicated in control of the inflammatory state of adipose tissue and, thereby, insulin sensitivity. Here we identify peroxisome proliferator-activated receptor (PPAR)-γ, the 'master regulator' of adipocyte differentiation, as a crucial molecular orchestrator of VAT Treg cell accumulation, phenotype and function. Unexpectedly, PPAR-γ expression by VAT Treg cells was necessary for complete restoration of insulin sensitivity in obese mice by the thiazolidinedione drug pioglitazone. These findings suggest a previously unknown cellular mechanism for this important class of thiazolidinedione drugs, and provide proof-of-principle that discrete populations of Treg cells with unique functions can be precisely targeted to therapeutic ends.     

融合双通道音节特征的藏文La格例句自动分类模型

基于藏文La格(??????)例句的自动分类在藏语自然语言处理领域的重要性,根据藏文La格的用法和添接规则,在对藏文La格例句进行分类并定义分类概念的基础上,提出一种融合双通道音节特征的藏文La格例句自动分类模型.该模型首先使用word2vec和Glove构建双通道藏文音节嵌入,分别在每路卷积中融合双通道音节特征,丰富...     

Three mutant insulins in man

We have previously identified a structurally abnormal insulin in the serum and pancreas of a middle-aged man with diabetes mellitus which arose from a leucine for phenylalanine substitution at position 24 or 25 of the insulin B chain; further analysis of the patient's leukocyte DNA showed that one of the patient's insulin alleles had undergone mutation resulting in loss of an MboII restriction site normally present in the human insulin gene. Two additional and unrelated patients with the same clinical syndrome have now been identified (ref. 4 and unpublished results). All of these patients showed hyperglycaemia typical of diabetes and with marked hyperinsulinaemia typical of insulin resistance, but all three show normal tolerance to exogenously administered insulin. As the opportunity of examining pancreatic tissue from patients suspected of secreting insulin variants is rare, we have developed a method combining HPLC and radioimmunoassay to identify insulin variants isolated from human sera. By this method we have shown that all three patients noted above secrete structurally variant and chemically distinct insulins. In correction of our original assignment, one is identified as [LeuB25]insulin.     

高校计算机课程教学与改革探讨

以计算机为核心的多媒体教学在我国高校已经蓬勃兴起。文章针对现在教育面临的新形式,进行了高校计算机课程的教学与改革探讨。针对电子科技大学已经开展的多媒体式、专周式教学,就如何培养学生技能、提高动手能力,为最后的就业打下坚实基础提出了一些想法和建议。并对一些教学方法的效果进行了统计分析,通过分析和探讨,结合教学实际,提出了一些措施与建议,希望对探讨高校计算机专业教学、学习、就业有所帮助。     

Receptor binding redefined by a structural switch in a mutant human insulin

Crystal structures of insulin have been determined in various distinct forms, the relevance of which to receptor recognition has long been the subject of speculation. Recently the crystal structure of an inactive insulin analogue has been determined and, surprisingly, found to have a conformation identical to native insulin. On this basis Dodson and colleagues have suggested that the known insulin crystal structures reflect an inactive conformation, and that a change in conformation is required for activity--specifically, the carboxy terminal residues of the B-chain are proposed to separate from the amino terminal residues of the A-chain. Here we report the solution structure of an active insulin mutant, determined by two-dimensional NMR, which supports this hypothesis. In the mutant, the carboxy terminal beta-turn and beta-strand of the B-chain are destabilized and do not pack across the rest of the molecule. We suggest that analogous detachment of the carboxy terminal region of the B-chain occurs in native insulin on binding to its receptor. Our finding that partial unfolding of the B-chain exposes an alternative protein surface rationalizes the receptor-binding properties of a series of anomalous insulin analogues, including a mutant insulin associated with diabetes mellitus in man.