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1.
It has been debated whether the extinct quagga was a distinct fourth species of African zebra or whether it was merely the southern variant of the Plains zebra (Equus burchelli). Using a radioimmunoassay (RIA) technique, we have shown that proteins remaining in quagga skins from museums are much more similar to serum proteins of the Plains zebra than to those of the other two extant zebras. 相似文献
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HLA-D region beta-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals 总被引:19,自引:0,他引:19
D Owerbach A Lernmark P Platz L P Ryder L Rask P A Peterson J Ludvigsson 《Nature》1983,303(5920):815-817
The human HLA-D histocompatibility region encodes class II antigens each of which consists of two polypeptide chains (alpha and beta) inserted in the plasma membrane. These molecules are implicated in the regulation of the immune response but several human diseases are also found to be associated with certain HLA-DR antigens. The occurrence of insulin-dependent (type I) diabetes (IDDM) is strongly associated with HLA-DR3 and/or 4 (ref. 5). The class II antigens, however, show a marked genetic polymorphism associated with the beta-chains which seem, from hybridization studies, to be encoded by several genes. We have therefore used the beta-chain cDNA probe, pDR-beta-1 (refs 8, 10) to test whether there are differences in hybridization pattern between DNA from healthy individuals and diabetic patients, after digestion with restriction endonucleases. Among the HLA-DR 4 and 3/4 individuals, the IDDM patients showed an increased frequency of a PstI 18 kilobase (kb) fragment. A BamHI 3.7 kb fragment, frequent among controls (30-40%), was rarely detected in the IDDM patients (0-2%). These differences may be related to susceptibility to develop the disease. 相似文献
3.
Summary It has been debated whether the extinct quagga was a distinct fourth species of African zebra or whether it was merely the southern variant of the Plains zebra (Equus burchelli). Using a radioimmunoassay (RIA) technique, we have shown that proteins remaining in quagga skins from museums are much more similar to serum proteins of the Plains zebra than to those of the other two extant zebras. 相似文献
4.
Andrew P. Abbott Gero Frisch Jennifer Hartley Wrya O. Karim Karl S. Ryder 《自然科学进展(英文版)》2015,25(6):595-602
The anodic dissolution of metals is an important topic for battery design, material finishing and metal digestion. Ionic liquids are being used in all of these areas but the research on the anodic dissolution is relatively few in these media. This study investigates the behaviour of 9 metals in an ionic liquid [C4mim][Cl] and a deep eutectic solvent, Ethaline, which is a 1:2 mol ratio mixture of choline chloride and ethylene glycol. It is shown that for the majority of metals studied a quasi-passivation of the metal surface occurs, primarily due to the formation of insoluble films on the electrode surface. The behaviour of most metals is different in [C4mim][Cl] to that in Ethaline due in part to the differences in viscosity. The formation of passivating salt films can be decreased with stirring or by increasing the electrolyte temperature, thereby increasing ligand transport to the electrode surface. 相似文献
5.
杀菌剂对木霉菌的毒性以及农业土壤中木霉菌分离与计数用选择性培养基 总被引:2,自引:0,他引:2
通过添加三唑酮刺激分生孢子产量、添加苯菌灵刺激营养生长以及添加曲里通X-100限制菌落扩展。本文进一步优化了木霉菌的选择性分离与计数培养基。三唑酮能有效地抑制轮枝菌生长。在该培养基上青霉菌和曲霉菌的生长受到明显抑制。在测定了多种杀菌剂对木霉菌以及相关的非木霉菌的毒性基础上,研制了更为可靠、有效的木霉菌选择性培养基。该培养基适合于从非木霉菌含量高的样本,也适合于从木霉菌含量低的样本中计数、分离木霉菌。无论样本中木霉菌的群体大还是小,利用该培养基均能进行计数和分离。 相似文献
6.
Goutham Narla Jaya Sangodkar Christopher B. Ryder 《Cellular and molecular life sciences : CMLS》2018,75(15):2695-2718
The dynamic and stringent coordination of kinase and phosphatase activity controls a myriad of physiologic processes. Aberrations that disrupt the balance of this interplay represent the basis of numerous diseases. For a variety of reasons, early work in this area portrayed kinases as the dominant actors in these signaling events with phosphatases playing a secondary role. In oncology, these efforts led to breakthroughs that have dramatically altered the course of certain diseases and directed vast resources toward the development of additional kinase-targeted therapies. Yet, more recent scientific efforts have demonstrated a prominent and sometimes driving role for phosphatases across numerous malignancies. This maturation of the phosphatase field has brought with it the promise of further therapeutic advances in the field of oncology. In this review, we discuss the role of phosphatases in the regulation of cellular proliferation and survival signaling using the examples of the MAPK and PI3K/AKT pathways, c-Myc and the apoptosis machinery. Emphasis is placed on instances where these signaling networks are perturbed by dysregulation of specific phosphatases to favor growth and persistence of human cancer. 相似文献
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木霉及其制剂对棉花真菌病害的防治效果 总被引:1,自引:0,他引:1
在盆栽条件下,9个木霉菌株对棉花丝核菌立枯病的防治效果为39.71%-82.35%,14个菌株对棉花枯萎病的防治效果为37.5%-75.00%,9个菌株对棉花黄萎病的防治效果为30.49%-65.85%。制备了绿色木霉LTR-2的可湿性粉剂,田问条件下处理种子及灌根,菌剂对棉花枯萎病的防治效果达50.1%-80.0%。 相似文献
9.
Observations are presented on 117 bird species seen in a 250-km 2 area of northwestern Colorado adjacent to Utah and Wyoming. Three previously unreported species and seven status changes are listed for the Rangely, Colorado, latilong block. 相似文献