Enhanced urease inhibition activity of Ag nanomaterials capped with N-substituted methyl 5-acetamido-β-resorcylate

Medically, bacterial ureases are important virulent factors and are used for treatment of peptic ulcers and urinary tones. Reported urease inhibitors are associated with various side effects including antibiotic resistance as a major one. Still there is an urgent need to synthesize new urease inhibitors. In this context we have synthesized new urease inhibitor i.e. AgL that is composed of Ag nanomaterials capped with N-substituted methyl 5-acetamido-β-resorcylate(L). The conjugation of L to silver was confirmed through FTIR, UV–vis and TEM analysis.Bare silver nanomaterials(Ag) were also prepared. The stability of AgL nanostructures was determined against various parameters(temperature, high salt concentration, pH) and found to be stable. The in vitro antimicrobial(antibacterial, antifungal), enzyme inhibition(xanthine oxidase, urease, carbonic anhydrase, α-chymotrypsin,cholinesterase) and antioxidant activities of AgL were investigated and compared with Ag, L and standard drugs.In comparison to other bioactivities, AgL shows statistically enhanced selective enzyme inhibition activity against urease enzyme. Urease inhibition activity of AgL was significantly greater than standard drug(thiourea),L and Ag. On a per weight basis, AgL required about 11–18 times less amount of L for inhibition of urease enzyme.     

Boundary layer flow and heat transfer of a micropolar fluid near the stagnation point on a stretching vertical surface with prescribed skin friction

The steady laminar mixed convection boundary layer flow and heat transfer of a micropolar fluid near the stagnation point on a stretched vertical surface with prescribed skin friction were considered. The governing partial differential equations were transformed into a system of ordinary differential equations, which were then solved numerically using the shooting method. Results for the stretching velocity, the local Nusselt number, the temperature, and the velocity profiles are presented for various values of the mixed convection parameter λ and material parameter K when the Prandtl number is equal to 1. Both assisting (heated plate) and opposing (cooled plate) flow regions are considered. It is found that dual solutions exist for both assisting and opposing flows.     

Magnetohydrodynamic flow over a moving plate in a parallel stream with an induced magnetic field

A viscous boundary layer flow of an electrically-conducting fluid over a moving flat plate in a parallel stream with a constant magnetic field applied outside the boundary layer parallel to the plate was investigated. The governing system of partial differential equations was transformed to ordinary differential equations using a similarity transformation. The similarity equations were then solved numerically using a finite-difference scheme known as the Keller-box method. Numerical results of the skin friction coefficient, velocity profiles, and the induced magnetic field profiles were obtained for some values of the moving parameter, magnetic parameter, and reciprocal magnetic Prandtl number. The results indicate that dual solutions exist when the plate and the fluid move in the opposite directions up to a critical value of the moving parameter, whose value depends on the value of the magnetic parameter.     

Similarity solutions for the mixed convection flow over a vertical plate with thermal radiation

The steady laminar boundary layer flow adjacent to a vertical plate with prescribed surface temperature immersed in an incompressible viscous fluid, where the effect of thermal radiation was taken into consideration, was investigated. The governing partial differential equations were transformed into a system of ordinary differential equations using similarity transformation, before being solved numerically by the shooting method. Both assisting and opposing buoyant flows were considered. It is found that dual solutions exist for both cases. Moreover, numerical results show that the heat transfer rate at the surface decreases in the presence of the radiation effect.