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Dennis D. Austin Robert A. Riggs Philip J. Urness David L. Turner John F. Kimball 《西北部美国博物学家》2011,49(1)
Trends in age-specific, eviscerated carcass weights were determined for hunter-harvested yearling and two-year-old buck mule deer. Carcass weights declined over an 11-year period from two areas of similar management, but with independenly collected data sets. Carcass weights also declined between the opening and second weekends of the hunt. Management implications are discussed. 相似文献
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Molecular mechanisms of chromosome pairing,folding and function 总被引:6,自引:0,他引:6
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Synthetic lac operator DNA is functional in vivo. 总被引:32,自引:0,他引:32
H L Heyneker J Shine H M Goodman H W Boyer J Rosenberg R E Dickerson S A Narang K Itakura S Lin A D Riggs 《Nature》1976,263(5580):748-752
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Syncytium-forming agent isolated from domestic cats 总被引:6,自引:0,他引:6
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Liu J O'Brien KL Lynch DM Simmons NL La Porte A Riggs AM Abbink P Coffey RT Grandpre LE Seaman MS Landucci G Forthal DN Montefiori DC Carville A Mansfield KG Havenga MJ Pau MG Goudsmit J Barouch DH 《Nature》2009,457(7225):87-91
A recombinant adenovirus serotype 5 (rAd5) vector-based vaccine for HIV-1 has recently failed in a phase 2b efficacy study in humans. Consistent with these results, preclinical studies have demonstrated that rAd5 vectors expressing simian immunodeficiency virus (SIV) Gag failed to reduce peak or setpoint viral loads after SIV challenge of rhesus monkeys (Macaca mulatta) that lacked the protective MHC class I allele Mamu-A*01 (ref. 3). Here we show that an improved T-cell-based vaccine regimen using two serologically distinct adenovirus vectors afforded substantially improved protective efficacy in this challenge model. In particular, a heterologous rAd26 prime/rAd5 boost vaccine regimen expressing SIV Gag elicited cellular immune responses with augmented magnitude, breadth and polyfunctionality as compared with the homologous rAd5 regimen. After SIV(MAC251) challenge, monkeys vaccinated with the rAd26/rAd5 regimen showed a 1.4 log reduction of peak and a 2.4 log reduction of setpoint viral loads as well as decreased AIDS-related mortality as compared with control animals. These data demonstrate that durable partial immune control of a pathogenic SIV challenge for more than 500 days can be achieved by a T-cell-based vaccine in Mamu-A*01-negative rhesus monkeys in the absence of a homologous Env antigen. These findings have important implications for the development of next-generation T-cell-based vaccine candidates for HIV-1. 相似文献
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A transcriptional repressor of c-myc 总被引:21,自引:0,他引:21
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Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease) 总被引:19,自引:0,他引:19
Nishino I Fu J Tanji K Yamada T Shimojo S Koori T Mora M Riggs JE Oh SJ Koga Y Sue CM Yamamoto A Murakami N Shanske S Byrne E Bonilla E Nonaka I DiMauro S Hirano M 《Nature》2000,406(6798):906-910
"Lysosomal glycogen storage disease with normal acid maltase" which was originally described by Danon et al., is characterized clinically by cardiomyopathy, myopathy and variable mental retardation. The pathological hallmark of the disease is intracytoplasmic vacuoles containing autophagic material and glycogen in skeletal and cardiac muscle cells. Sarcolemmal proteins and basal lamina are associated with the vacuolar membranes. Here we report ten unrelated patients, including one of the patients from the original case report, who have primary deficiencies of LAMP-2, a principal lysosomal membrane protein. From these results and the finding that LAMP-2-deficient mice manifest a similar vacuolar cardioskeletal myopathy, we conclude that primary LAMP-2 deficiency is the cause of Danon disease. To our knowledge this is the first example of human cardiopathy-myopathy that is caused by mutations in a lysosomal structural protein rather than an enzymatic protein. 相似文献
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