具有三个CM公共值的亚纯函数的唯一性

本文指出仪洪勋和Brosch G在具有三个判别的CM公共值的亚纯函数的唯一性定理中,关于对数函数的导数是整函数的推导,可以用指数函数求导的方法来证明.改进了仪洪勋和Brosch G关于重值与唯一性定理.     

A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal

The 26S proteasome is the chief site of regulatory protein turnover in eukaryotic cells. It comprises one 20S catalytic complex (composed of four stacked rings of seven members) and two axially positioned 19S regulatory complexes (each containing about 18 subunits) that control substrate access to the catalytic chamber. In most cases, targeting to the 26S proteasome depends on tagging of the substrate with a specific type of polyubiquitin chain. Recognition of this signal is followed by substrate unfolding and translocation, which are presumably catalysed by one or more of six distinct AAA ATPases located in the base-a ring-like 19S subdomain that abuts the axial pore of the 20S complex and exhibits chaperone activity in vitro. Despite the importance of polyubiquitin chain recognition in proteasome function, the site of this signal's interaction with the 19S complex has not been identified previously. Here we use crosslinking to a reactive polyubiquitin chain to show that a specific ATPase subunit, S6' (also known as Rpt5), contacts the bound chain. The interaction of this signal with 26S proteasomes is modulated by ATP hydrolysis. Our results suggest that productive recognition of the proteolytic signal, as well as proteasome assembly and substrate unfolding, are ATP-dependent events.     

Pain relief by xenograft of subarachnoid microencapsulated bovine chromaffin cells in cancer patients

The bovine chromaffin cells (BCC) implanted into the subarachnoid space can release analgesic substances such as opioid peptides and ealeeholamines. Clinical trials have provided the evidence that the implantation of polyvinylchloride ( PVC) hollow fiber encapsulated BCC by surgery can relief the pain in cancer patients. In the present study, BCC were encapsulated in alginate-polylysine-alginate (APA) mieroencapsules which protect the grafting of xenogeneic cells from host immune system anil allow BCC to function effectively without using immunosuppression agents. The microencapsulated BCCs (5 X 106~—8 X 106) were transplanted into the subarachnoid space I^._s of 17 patients who suffered from chronic cancer pain and had to have long-term administration of analgesics. The pain scores and morphine intake tesl showed that microencapsulated BCC graft totally stopped the chronic pain in three of the patients over a period of 200 days and in the other three over a period of 100 days. The resulls suggesl thai APA microencapsulated BCC xenotransplantation could be a novel alternative approach to managing pain of cancer patients.     

Growth-modulating serum tripeptide is glycyl-histidyl-lysine

Summary The structure of a growth-modulating tripeptide from human serum and plasma has been determined to be H-glycyl-histidyl-lysine-OH.Acknowledgment. This work was supported by grants from the U.S. Public Health Service (HD-03148 and P17AM 18520) and from the National Cancer Institute (NO-1-CB53868).     

Deep convection in the Irminger Sea forced by the Greenland tip jet

Open-ocean deep convection, one of the processes by which deep waters of the world's oceans are formed, is restricted to a small number of locations (for example, the Mediterranean and Labrador seas). Recently, the southwest Irminger Sea has been suggested as an additional location for open-ocean deep convection. The deep water formed in the Irminger Sea has the characteristic temperature and salinity of the water mass that fills the mid-depth North Atlantic Ocean, which had been believed to be formed entirely in the Labrador basin. Here we show that the most likely cause of the convection in the Irminger Sea is a low-level atmospheric jet known as the Greenland tip jet, which forms periodically in the lee of Cape Farewell, Greenland, and is associated with elevated heat flux and strong wind stress curl. Using a history of tip-jet events derived from meteorological land station data and a regional oceanic numerical model, we demonstrate that deep convection can occur in this region when the North Atlantic Oscillation Index is high, which is consistent with observations. This mechanism of convection in the Irminger Sea differs significantly from those known to operate in the Labrador and Mediterranean seas.