耐水脱硫石膏、粉煤灰胶结材的研究

本文较深入地研究了脱硫石膏粉煤灰化学成分、杂质、颗粒特征和激发剂等对脱硫石膏、粉煤灰胶结材性能的影响 研究表明 ,激发剂是影响脱硫石膏、粉煤灰胶结材性能的主要因素 这为脱硫石膏、粉煤灰资源化利用打下良好理论基础 经实际应用表明 ,研究结果与实际情况能很好相符     

正弦稳态扫频信号的产生与输出

介绍用计算机软件产生正弦稳态扫频信号的编程方法。通过对Ｄ／Ａ变换与Ａ／Ｄ采集的同步输出可以获得不同频率量程和设定电压的扫频输出     

一类高阶非线性系统的零解稳定性

由Барбащин公式得到的四阶常系数线性系统的Ляпунов函数出发，通过类比法构造了一类四阶非线性系统的Ляпунов函数，并由此得到了这些系统零解的全局渐近稳定性的充分条件     

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

Coumarin derivatives such as warfarin represent the therapy of choice for the long-term treatment and prevention of thromboembolic events. Coumarins target blood coagulation by inhibiting the vitamin K epoxide reductase multiprotein complex (VKOR). This complex recycles vitamin K 2,3-epoxide to vitamin K hydroquinone, a cofactor that is essential for the post-translational gamma-carboxylation of several blood coagulation factors. Despite extensive efforts, the components of the VKOR complex have not been identified. The complex has been proposed to be involved in two heritable human diseases: combined deficiency of vitamin-K-dependent clotting factors type 2 (VKCFD2; Online Mendelian Inheritance in Man (OMIM) 607473), and resistance to coumarin-type anticoagulant drugs (warfarin resistance, WR; OMIM 122700). Here we identify, by using linkage information from three species, the gene vitamin K epoxide reductase complex subunit 1 (VKORC1), which encodes a small transmembrane protein of the endoplasmic reticulum. VKORC1 contains missense mutations in both human disorders and in a warfarin-resistant rat strain. Overexpression of wild-type VKORC1, but not VKORC1 carrying the VKCFD2 mutation, leads to a marked increase in VKOR activity, which is sensitive to warfarin inhibition.