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Summary Replicative DNA synthesis in permeable mouse sarcoma cells was more sensitive to ethidium bromide (EtBr) than bleomycin-induced unscheduled DNA synthesis (UDS). A similar difference in sensitivity to EtBr was observed between DNA polymerases and . The difference in sensitivity to EtBr of replicative DNA synthesis and UDS in the present system seems to reflect mainly the sensitivity difference between DNA polymerases and .Acknowledgments. The authors wish to thank Nippon Kayaku Co. (Tokyo, Japan) for providing copper-free bleomycin A2. This research was supported in part by a grant from the Japan Ministry of Education, Science and Culture. 相似文献
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RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta 总被引:18,自引:0,他引:18
Takayanagi H Kim S Matsuo K Suzuki H Suzuki T Sato K Yokochi T Oda H Nakamura K Ida N Wagner EF Taniguchi T 《Nature》2002,416(6882):744-749
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Epidermal growth factor stimulated both [3H]thymidine uptake and proliferation of rat AH66 hepatoma cells. However, the increase in cell number was not accompanied by a proportional increase in the levels of alpha-fetoprotein of the culture media. The effects of EGF on the cell proliferation were antagonized by N6,O2'-dibutyryl cAMP. 相似文献
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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus 总被引:62,自引:0,他引:62
Horikawa Y Oda N Cox NJ Li X Orho-Melander M Hara M Hinokio Y Lindner TH Mashima H Schwarz PE del Bosque-Plata L Horikawa Y Oda Y Yoshiuchi I Colilla S Polonsky KS Wei S Concannon P Iwasaki N Schulze J Baier LJ Bogardus C Groop L Boerwinkle E Hanis CL Bell GI 《Nature genetics》2000,26(2):163-175
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes. 相似文献
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Y. Kaneko Y. Imai F. Matsuzaki Y. Endo T. Oda 《Cellular and molecular life sciences : CMLS》1979,35(12):1660-1661
Summary Epidermal growth factor stimulated both [3H]thymidine uptake and proliferation of rat AH66 hepatoma cells. However, the increase in cell number was not accompanied by a proportional increase in the levels of -fetoprotein of the culture media. The effects of EGF on the cell proliferation were antagonized by N6, O2-dibutyryl cAMP. 相似文献
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Summary 1--D-Arabinofuranosyl cytosine-5-triphosphate (araCTP), an inhibitor of DNA synthesis, paradoxically enhanced unscheduled DNA synthesis (USD) induced by bleomycin in permeable mouse sarcoma cells. A greater enhancing effect of araCTP on bleomycin-induced USD was observed with lower concentrations of dCTP in the assay mixture. USD measured without bleomycin in nuclei isolated from mouse sarcoma cells was not enhanced, but inhibited by araCTP.Acknowledgments. The authors wish to thank Nippon Kayaku Co. (Tokyo, Japan) for providing copper-free bleomycin A2. This research was supported in part by a grant from the Japan Ministry of Education, Science and Culture. 相似文献
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Actin filaments form the backbone of nemaline myopathy rods 总被引:10,自引:0,他引:10
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Résumé L'ionophone est un émetteur sonique et ultra-sonique qui utilise la particularité qu'ont les gaz d'être ionisés sous l'effet d'une tension électrique très élevée et de haute fréquence. Ce générateur est aussi un ozoniseur efficient et il est nécessaire de ne l'employer qu'avec une ventilation appropriée.
Paper No. 2397 in the Journal Series of the Agricultural Experiment Station. 相似文献
Paper No. 2397 in the Journal Series of the Agricultural Experiment Station. 相似文献