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排序方式: 共有211条查询结果,搜索用时 15 毫秒
1.
Aluminum based metal matrix composites are offering o utstanding properties in a number of automotive and aircraft components and body structures. The major advantages of these composite materials are their high st rength to weight ratio, high stiffness, high hardness, wear resistance, low coef ficient of thermal expansion, superior dimensional stability and versatility to designer. In addition to these their isotropic properties, good forming characte ristics, easy availability of cheaper reinforcements... 相似文献
2.
Summary The level of the acid hydrolases -glucuronidase (EC 3.2.3.11), acid phosphatase (EC 3.1.3.2) and acid protease (EC 3.4.4) was studied during larval growth and molting inP. ricini. The level of activity of these enzymes remained low during larval growth; however, the level increased sharply at the time of molting and declined sharply thereafter in the newly ecdysed insect. Interestingly, the diminished activity of these enzymes was almost quantitatively recovered in the cast-off cuticle. The excretion of acid hydrolases through the cast-off cuticle has hitherto not been reported in insects during molting. 相似文献
3.
Biodiesel fuel is found to be a promising alter- native for the petroleum diesel based on the results published by the researchers for a decade. Biodiesel fuel is renewable and non degradable fuel. Many countries use biodiesel fuel for automotives to meet the crisis due to the depletion of the petroleum fuel and to meet the stringent emission norms. Various researches have been carried out with different bio- diesel fuels with vegetable oil as the source and appreciable results were reported. Few biodiesel fuels which have been already tested are Jatropha, Pongamia, Mahua, neem, cotton seed, etc. In this experimental work, Adelfa biodiesel blend is used as the test fuel. The emission and performance charac- teristics were compared with three other different biodiesel fuel blends. Appreciable results imply that Adelfa biodiesel (Nerium oil methyl ester) can be a futuristic biodiesel fuel, which has a good compatibility with the direct injection (DI) diesel engine without any major modification. Moreover, Adelfa can be cultivated in a non agricultural land with fewer sources of water. It is widely spread over all major countries of Asia. Experimental investigations have been carried out on a single cylinder DI diesel engine with standard engine speci- fications. In this experimental work, various Adelfa biodiesel blends is compared with reference fuel (diesel) to choose the best blend which gives a closer performance to diesel. The comparative analysis with other biodiesel fuels has also been done and results have been discussed. 相似文献
4.
Abhishek Pathak Biswajyoti Mukherjee Krishna Kant Pandey Aminul Islam Pavan Bijalwan Monojit Dutta Atanu Banerjee Anup Kumar Keshri 《矿物冶金与材料学报》2022,1(1):144-152
本研究试图通过优化等离子喷涂参数来开发一种Fe基非晶/晶体涂层,该涂层主要成分来自一种贫乏的铁基合金(Fe92.6C3.5P1.4Si2Mn0.5)。这种合金是钢铁厂高炉产出的生铁剩余废料。为了经济有效地重新利用这种残留物,这种合金在合成时对成分进行了最少的修改。同时,本研究还探讨了涂层的结构、机械、腐蚀和磨损性能对喷涂参数(等离子功率、主气体流速、送粉速度和间隔距离)的依赖性。X射线衍射表明,在最优的喷涂参数下沉积的涂层存在无定形/晶体相。在较低等离子功率和最高气体流速下沉积的涂层表现出更好的密度、硬度和耐磨性。所有涂层都表现出良好的耐腐蚀性(腐蚀环境:3.5wt% NaCl 溶液)。机械、磨损和摩擦学研究表明,单一的工艺参数优化无法提供良好的涂层性能;相反,所有工艺参数在优化涂层性能都具有独一无二的作用,它们主要通过控制飞行中的颗粒温度和速度分布,以及熔滴撞击基材之前的冷却模式来控制涂层性能。 相似文献
5.
Accurate business failure prediction models would be extremely valuable to many industry sectors, particularly financial investment and lending. The potential value of such models is emphasised by the extremely costly failure of high‐profile companies in the recent past. Consequently, a significant interest has been generated in business failure prediction within academia as well as in the finance industry. Statistical business failure prediction models attempt to predict the failure or success of a business. Discriminant and logit analyses have traditionally been the most popular approaches, but there are also a range of promising non‐parametric techniques that can alternatively be applied. In this paper, the relatively new technique of decision trees is applied to business failure prediction. The numerical results suggest that decision trees could be superior predictors of business failure as compared to discriminant analysis. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
6.
Danielle Kamato Muhamad Ashraf Rostam Rebekah Bernard Terrence J. Piva Nitin Mantri Daniel Guidone Wenhua Zheng Narin Osman Peter J. Little 《Cellular and molecular life sciences : CMLS》2015,72(4):799-808
G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier. 相似文献
7.
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 总被引:14,自引:0,他引:14
van Heel DA Franke L Hunt KA Gwilliam R Zhernakova A Inouye M Wapenaar MC Barnardo MC Bethel G Holmes GK Feighery C Jewell D Kelleher D Kumar P Travis S Walters JR Sanders DS Howdle P Swift J Playford RJ McLaren WM Mearin ML Mulder CJ McManus R McGinnis R Cardon LR Deloukas P Wijmenga C 《Nature genetics》2007,39(7):827-829
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. 相似文献
8.
Community structure is an integral characteristic of real world networks whichever processes or areas they emerge from. This paper addresses the problem of community structure detection theoretically as well as computationally. The authors introduce a number of concepts such as the neighbourhood and strength of a subgraph, p-community, local maximal p-community, hubs, and outliers that play elemental role in formalising the concept of community structure in complex networks. A few preliminary results have been derived that lead to the development of an algorithm for community structure detection in undirected unweighted networks. The algorithm is based on a local seed expansion strategy that uses the concept of interaction coefficient. The authors have analysed the algorithm on a number of parameters such as accuracy, stability, and quality on synthetic and real world networks from different areas. 相似文献
9.
Anderson BH Kasher PR Mayer J Szynkiewicz M Jenkinson EM Bhaskar SS Urquhart JE Daly SB Dickerson JE O'Sullivan J Leibundgut EO Muter J Abdel-Salem GM Babul-Hirji R Baxter P Berger A Bonafé L Brunstom-Hernandez JE Buckard JA Chitayat D Chong WK Cordelli DM Ferreira P Fluss J Forrest EH Franzoni E Garone C Hammans SR Houge G Hughes I Jacquemont S Jeannet PY Jefferson RJ Kumar R Kutschke G Lundberg S Lourenço CM Mehta R Naidu S Nischal KK Nunes L Ounap K Philippart M Prabhakar P Risen SR 《Nature genetics》2012,44(3):338-342
Coats plus is a highly pleiotropic disorder particularly affecting the eye, brain, bone and gastrointestinal tract. Here, we show that Coats plus results from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammalian homolog of the yeast heterotrimeric CST telomeric capping complex. Consistent with the observation of shortened telomeres in an Arabidopsis CTC1 mutant and the phenotypic overlap of Coats plus with the telomeric maintenance disorders comprising dyskeratosis congenita, we observed shortened telomeres in three individuals with Coats plus and an increase in spontaneous γH2AX-positive cells in cell lines derived from two affected individuals. CTC1 is also a subunit of the α-accessory factor (AAF) complex, stimulating the activity of DNA polymerase-α primase, the only enzyme known to initiate DNA replication in eukaryotic cells. Thus, CTC1 may have a function in DNA metabolism that is necessary for but not specific to telomeric integrity. 相似文献
10.
Kris Meerschaert Moe Phyu Tun Eline Remue Ariane De Ganck Ciska Boucherie Berlinda Vanloo Gisèle Degeest Joël Vandekerckhove Pascale Zimmermann Nitin Bhardwaj Hui Lu Wonhwa Cho Jan Gettemans 《Cellular and molecular life sciences : CMLS》2009,66(24):3951-3966
Zonula occludens proteins (ZO) are postsynaptic density protein-95 discs large-zonula occludens (PDZ) domain-containing proteins that play a fundamental role in the assembly of tight junctions and establishment of cell polarity. Here, we show that the second PDZ domain of ZO-1 and ZO-2 binds phosphoinositides (PtdInsP) and we identified critical residues involved in the interaction. Furthermore, peptide and PtdInsP binding of ZO PDZ2 domains are mutually exclusive. Although lipid binding does not seem to be required for plasma membrane localisation of ZO-1, phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P 2) binding to the PDZ2 domain of ZO-2 regulates ZO-2 recruitment to nuclear speckles. Knockdown of ZO-2 expression disrupts speckle morphology, indicating that ZO-2 might play an active role in formation and stabilisation of these subnuclear structures. This study shows for the first time that ZO isoforms bind PtdInsPs and offers an alternative regulatory mechanism for the formation and stabilisation of protein complexes in the nucleus. 相似文献