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1.
Birds of a Feather Protest Together: Theorizing Self-Organizing Political Protests with Flock Theory 总被引:1,自引:0,他引:1
The current research theorizes decentralized and self-organized political protests via flock theory (Rosen 2002), a theory of emergent self-organization in communicative human interaction. Flock theory draws from a theoretical basis
of emergence and self-organizing systems, and is presented as a theory of decentralized communication structures. Focusing
on the optimization of decentralized networks and roadmap based coordination of organizationally homopholous foci; the current
theory poses a model of human interaction that captures the potentially egalitarian effects of cooperative evolution and collective
action. Case studies of two separate decentralized political protests against Korean government and FARC are offered as evidences
of such phenomena. 相似文献
2.
Drosophila Crumbs (Crb) is required for apical-basal polarity and is an apical determinant in embryonic epithelia. Here, we describe properties of Crb that control the position and integrity of the photoreceptor adherens junction and photosensitive organ, or rhabdomere. In contrast to normal photoreceptor adherens junctions and rhabdomeres, which span the depth of the retina, adherens junctions and rhabdomeres of Crb-deficient photoreceptors initially accumulate at the top of the retina and fail to maintain their integrity as they stretch to the retinal floor. We show that Crb controls localization of the adherens junction through its intracellular domain containing a putative binding site for a protein 4.1 superfamily protein (FERM). Although loss of Crb or overexpression of the FERM binding domain causes mislocalization of adherens junctions, they do not result in a significant loss of photoreceptor polarity. Mutations in CRB1, a human homologue of crb, are associated with photoreceptor degeneration in retinitis pigmentosa 12 (RP12) and Leber congenital amaurosis (LCA). The intracellular domain of CRB1 behaves similarly to its Drosophila counterpart when overexpressed in the fly eye. Our studies may provide clues for mechanisms of photoreceptor degeneration in RP12 and LCA. 相似文献
3.
N. P. Buu-Hoï A. Bouffanais P. Gley N. D. Xuong N. H. Nam 《Cellular and molecular life sciences : CMLS》1956,12(2):73-75
Summary A large number of sulphur-containing compounds bearing the thiourea group -NH-CS-NH-, including substituted thiocarbanilides, 1-acyl-4-arylthiosemicar-bazides, 1-(arylaminothioformyl)-thiosemicarbazides, 4-aryl-1-(arylaminothioformyl)- thiosemicarbazides, and other related substances have been tested for potential antiviral activity. Several of these compounds have been found chemotherapeutically active against influenza virus.
Communication présentée au Congrès international de Chimie pure et appliquée de Zürich (Juillet 1955). 相似文献
Communication présentée au Congrès international de Chimie pure et appliquée de Zürich (Juillet 1955). 相似文献
4.
Song K Nam YJ Luo X Qi X Tan W Huang GN Acharya A Smith CL Tallquist MD Neilson EG Hill JA Bassel-Duby R Olson EN 《Nature》2012,485(7400):599-604
5.
Control of plant germline proliferation by SCF(FBL17) degradation of cell cycle inhibitors 总被引:1,自引:0,他引:1
Flowering plants possess a unique reproductive strategy, involving double fertilization by twin sperm cells. Unlike animal germ lines, the male germ cell lineage in plants only forms after meiosis and involves asymmetric division of haploid microspores, to produce a large, non-germline vegetative cell and a germ cell that undergoes one further division to produce the twin sperm cells. Although this switch in cell cycle control is critical for sperm cell production and delivery, the underlying molecular mechanisms are unknown. Here we identify a novel F-box protein of Arabidopsis thaliana, designated FBL17 (F-box-like 17), that enables this switch by targeting the degradation of cyclin-dependent kinase A;1 inhibitors specifically in male germ cells. We show that FBL17 is transiently expressed in the male germ line after asymmetric division and forms an SKP1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase complex (SCF(FBL17)) that targets the cyclin-dependent kinase inhibitors KRP6 and KRP7 for proteasome-dependent degradation. Accordingly, the loss of FBL17 function leads to the stabilization of KRP6 and inhibition of germ cell cycle progression. Our results identify SCF(FBL17) as an essential male germ cell proliferation complex that promotes twin sperm cell production and double fertilization in flowering plants. 相似文献
6.
This paper presents an experimental research aiming to realize an artificial hind wing that can mimic the wing unfolding motion of AIIomyrina dichotoma, an insect in coleopteran order. Based on the understanding of working principles of beetle wing folding/unfolding mechanisms, the hind wing unfolding motion is mimicked by a combination of creative ideas and state-of-art artificial muscle actuator. In this work, we devise two types of artificial wings and the successfully demonstrate that they can be unfolded by actuation of shape memory alloy wires to provide actuation force at the wing base and along the leading edge vein. The folding/unfolding mechanisms may provide an insight for portable nano/micro air vehicles with morphing wings. 相似文献
7.
Nam Q Nguyen Laura K Bryant Carly M Burgstad Robert J Fraser Daniel Sifrim Richard H Holloway 《河南科技》2010,(3)
AIM: To assess the impact of bolus volume on the characteristics of small intestinal (SI) impedance signals.METHODS: Concurrent SI manometry-impedance measurements were performed on 12 healthy volunteers to assess the pattern of proximal jejunal fluid bolus movement over a 14 cm-segment.Each subject was given 34 boluses of normal saline (volume from 1 to 30 mL) via the feeding tube placed immediately above the proximal margin of the studied segment.A bolus-induced impedance event occurred if there was > 12%... 相似文献
8.
He L Zhang Z Yu Y Ahmed S Cheung NS Qi RZ 《Cellular and molecular life sciences : CMLS》2011,68(9):1633-1643
The neuronal Cdk5 activator p35 is involved in a multitude of neuronal activities, including cytoskeletal organization. We
show here that p35 directly interacts with filamentous actin (F-actin) but not with monomeric actin (G-actin). Through binding,
p35 induces the formation of actin bundles and stabilizes F-actin against dilution-induced depolymerization. p35 forms intermolecular
self-associations, suggesting that p35 cross-links actin filaments into bundles via its intermolecular self-association. p35
dimerization and association with F-actin occur at the N-terminal region that is absent in the calpain-cleaved product p25,
indicating that such p35 properties are lost by its truncation induced under neurotoxic conditions. Using p35 phosphorylated
by Cdk5 and a mutational approach, we demonstrate that the phosphorylation of p35 promotes its homodimerization and p35-induced
formation of F-actin bundles. In addition, the phosphorylation regulates p35 distribution to microtubule and actin cytoskeletons.
Together, these observations define a novel function for p35 in cytoskeletal regulation. 相似文献
9.
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits 总被引:1,自引:0,他引:1
Kim YJ Go MJ Hu C Hong CB Kim YK Lee JY Hwang JY Oh JH Kim DJ Kim NH Kim S Hong EJ Kim JH Min H Kim Y Zhang R Jia W Okada Y Takahashi A Kubo M Tanaka T Kamatani N Matsuda K;MAGIC consortium Park T Oh B Kimm K Kang D Shin C Cho NH Kim HL Han BG Lee JY Cho YS 《Nature genetics》2011,43(10):990-995
To identify the genetic bases for nine metabolic traits, we conducted a meta-analysis combining Korean genome-wide association results from the KARE project (n = 8,842) and the HEXA shared control study (n = 3,703). We verified the associations of the loci selected from the discovery meta-analysis in the replication stage (30,395 individuals from the BioBank Japan genome-wide association study and individuals comprising the Health2 and Shanghai Jiao Tong University Diabetes cohorts). We identified ten genome-wide significant signals newly associated with traits from an overall meta-analysis. The most compelling associations involved 12q24.11 (near MYL2) and 12q24.13 (in C12orf51) for high-density lipoprotein cholesterol, 2p21 (near SIX2-SIX3) for fasting plasma glucose, 19q13.33 (in RPS11) and 6q22.33 (in RSPO3) for renal traits, and 12q24.11 (near MYL2), 12q24.13 (in C12orf51 and near OAS1), 4q31.22 (in ZNF827) and 7q11.23 (near TBL2-BCL7B) for hepatic traits. These findings highlight previously unknown biological pathways for metabolic traits investigated in this study. 相似文献
10.
N. P. Buu-Hoï N. D. Xuong N. H. Nam J. M. Gazave J. Pillot L. Schembri 《Cellular and molecular life sciences : CMLS》1955,11(3):97-98
Summary A number of new diversely substituted thiocarbanilides and N-aryl-N-naphthylthioureas have been found which display pronounced tuberculostatic activityin vitro. One of these compounds, 4-ethyl-4-isoamyloxythiocarbanilide, proved to be particularly effective. 相似文献